Fingerprint detection method of Xiaochaihu granule compound preparation
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A technology of Xiao Chai Hu granules and a detection method, which is applied in the directions of measuring devices, instruments, scientific instruments, etc., can solve problems such as the inability to guarantee clinical efficacy, and achieve the effect of simple and convenient testing process and comprehensive detection.
Active Publication Date: 2018-08-28
CHENGDU PUSH BIOLOGICAL TECH
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Therefore, there is no better and more complete quality control method in the existing quality standards and other prior art to fully and accurately control product quality, which cannot better guarantee its clinical efficacy.
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Embodiment 1
[0052] First, prepare a mixed solution of reference substance: select 6.10 mg of baicalein reference substance, put it in a 5mL volumetric flask, dissolve it with methanol and set the volume to the mark, and use it as a baicalein stock solution. Take 1.0ml of baicalein stock solution and place it in a 10ml volumetric flask, dilute it to the mark with methanol, and prepare a baicalein reference substance stock solution with a concentration of 0.122mg / mL. Referring to the configuration method of the above-mentioned baicalein reference substance stock solution, configure baicalin, tangshenoside, saikosaponin C, wogonin, 6-gingerol, ammonium glycyrrhizinate, saikosaponin A and saikosaponin B2 for control Product stock solution, the concentration of its solution is successively 0.142mg / ml, 0.176mg / ml, 0.143mg / ml, 0.111mg / ml, 0.06mg / ml, 0.171mg / ml, 0.139mg / ml, 0.154mg / ml. When performing fingerprint detection, the above-mentioned baicalein, baicalin, tangshenoside, saikosaponin C, w...
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Abstract
The invention provides a fingerprint spectrum detecting method of a common goldenrop particle compound preparation, containing radix bupleuri, scutellaria baicalensis, codonopsis pilosula, ginger and licorice root. The method comprises firstly preparing baicalein, baicalin, Codonopsis pilosula Acetylene glycosides, saikoside C, wogonin, 6-gingerol, ammonium glycyrrhetate, saikoside A and saikoside B2 into a reference substance mixed solvent, secondly, extracting a common goldenrop particle compound preparation to be tested and extracting to prepare a test solvent, thirdly, sucking the reference substance mixed solvent and injecting into a high performance liquid chromatograph, and recording a contrast chromatogram, next, sucking the test solvent, injecting into the high performance liquid chromatograph, and recording a test chromatogram, and then comparing the contrast chromatogram and the test chromatogram. The detection method establishes a complete fingerprint spectrum detection method, the common goldenrop particle compound preparation is comprehensively detected, and quality of the common goldenrop particle compound preparation is more comprehensively and effectively controlled.
Description
technical field [0001] The invention relates to the technical field of detection of compound preparations of traditional Chinese medicines, and in particular to a method for detecting fingerprints of compound preparations of Xiaobupleurum granules. Background technique [0002] Xiaochaihu granule compound preparation is extracted and refined from Bupleurum, Scutellaria, Ginger Pinellia, Codonopsis Codonopsis, Ginger, Licorice and Jujube. For exogenous pathogenic diseases, Shaoyang syndrome of evil criminals, symptoms include alternating cold and heat, bitter fullness in the chest and hypochondrium, loss of appetite, restlessness and vomiting, bitter mouth and dry throat. [0003] The current quality control identification items of Xiaochaihu granule compound preparation in "Chinese Pharmacopoeia" are only through TLC identification of baicalin, licorice reference medicinal materials and Bupleurum reference medicinal materials, and one of the ingredients, baicalin, is selecte...
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