Ginger phenols extract preparation and preparation method thereof

A technology of extract and gingerol, which is applied in the field of gingerol extract soft capsules and its preparation, can solve the problem that the anti-motion sickness effect of ginger is greatly affected, ginger juice and ginger powder are unstable, and there is no anti-dizziness and antiemetic effect, etc. problems, to achieve the effect of reducing local irritation, good stability and sufficient resources

Inactive Publication Date: 2012-09-12
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, different preparation methods have a greater impact on the anti-motion sickness effect of ginger. Among them, ginger juice has the strongest anti-dizziness and antiemetic effect, which is significantly better than that of Haining. Quite, the anti-motion sickness effect of ginger acetone extract is equal to or slightly weaker than that of dizzy Haining, etc., the effect of ginger ethanol extract and water extract is small, and even has no anti-dizziness and antiemetic effect
However, both ginger juice and ginger powder are unstable, and it is difficult to prepare stable and convenient dosage forms
Extraction with organic solvents can easily cause part of the components to be lost or destroyed when the solvent is recovered

Method used

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  • Ginger phenols extract preparation and preparation method thereof
  • Ginger phenols extract preparation and preparation method thereof
  • Ginger phenols extract preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 prepares gingerols extract soft capsule

[0038] 1. The formula is:

[0039]

[0040]

[0041] 2 Preparation process

[0042] 2.1 Supercritical carbon dioxide extraction of gingerols extract:

[0043] (1) Cut the ginger into thin slices of 2-5mm, ventilate and dry at 45°C until the water content is less than 10%, crush it through a 40-mesh sieve to obtain ginger powder;

[0044] (2) Fill ginger powder into supercritical CO 2 In the extraction device, at a temperature of 55°C, a pressure of 30Mpa, CO 2 Flow rate is to extract under the condition of 10kg / h.kg raw material, and extraction time is 2 hours, then in the separation tank that pressure is 10Mpa, collect and obtain gingerols extract, its high performance liquid chromatogram is as follows figure 1 shown.

[0045] 2.2 Solution preparation

[0046] Preparation of the content solution: Accurately weigh 600g of gingerol extract, add 5400g of medicinal corn oil, stir fully at 60°C to dissolve t...

Embodiment 2～6

[0050] Embodiment 2~6 prepares gingerols extract soft capsule

[0051] The formula is as shown in Table 1:

[0052] Table 1:

[0053]

[0054] The preparation method is the same as in Example 1.

Embodiment 7～12

[0055] Examples 7-12: Preparation of Gingerols Extract Soft Capsules

[0056] Formula is as shown in table 2:

[0057] Table 2:

[0058]

[0059] All the other compositions and preparation methods are the same as in Example 1.

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Abstract

The invention relates to a ginger phenols extract preparation, in particular to a ginger phenols extract soft capsule and a preparation method thereof. The content of the soft capsule comprises 3-10 parts of ginger phenols extract and 40-60 parts of oleaginous base by weight part. Preferably, the content of the soft capsule comprises 6 parts of ginger phenols extract and 54 parts of corn oil by weight. The extraction method of the ginger phenols extract in the soft capsule is supercritical carbon dioxide extraction method which has the advantages of high extraction rate and high content of 6-gingerol. Meantime, the ginger phenols extract soft capsule has good stability.

Description

technical field [0001] The present invention relates to a ginger phenolic extract preparation, in particular to a ginger phenolic extract soft capsule and a preparation method thereof. Background technique [0002] The rapid development of modern means of transportation and aerospace has played an important role in promoting human economic, cultural and social life, but at the same time, it also caused some people to suffer from motion sickness. Motion sickness is a nervous system dysfunction caused by unaccustomed conditions in the exercise environment, mainly manifested as autonomic nervous system dysfunction. Symptoms usually develop progressively, ranging from stomach discomfort, nausea, increased salivation, pale complexion, cold sweats, dizziness, headache, to retching, vomiting, lethargy, and apathy. Those with severe vomiting may even become dehydrated and exhausted. It occurs when people ride in cars, boats, airplanes, amusement rides or when nautical, aviation, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/48A61K47/44A61P1/08A61K125/00
Inventor 董俊兴邹节明
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD
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