69 results about "Shogaol" patented technology

Summary Suggested is a ginger extract, comprising (a) 25 to 30 % b.w. [6]-gingerol (b) 5 to 10 % b.w. [8]-gingerol (c) 5 to 10 % b.w. [10]-gingerol (d) 1.5 to 4 % b.w. [6]-shogaol (e) 0.3 to 1.3 % b.w. [8]-shogaol; (f) 0.03 to 1 % b.w. [10]-shogaol; (g) 0.01 to 1 % b.w. zingerone, on condition that the amount of gingerols sums up to 35 to 50 % b.w. and the amount of shogaols sums up to 1.5 to 6 % b.w.

The invention discloses an emulsion composition which comprises a cold sensitizer, a heat sensitizer and water, wherein the mass ratio of the cold sensitizer to the heat sensitizer is 1:0.01-100; the cold sensitizer comprises at least one of piperitol, menthyl lactate, hexa-carbon cyclic amide derivative, non-carbon cyclic amide derivative, mint raw oil, mint oil, mint essence, mint leaf extract, water-soluble menthol and water-soluble mint oil; and the heat sensitizer comprises at least one of vanillyl butyl ether, citronellol n-propyl ether, citronellol isopropyl ether, citronellol isobutyl ether, citronellol n-amino ether, citronellol isoamyl ether, citronellol n-hexyl ether, citronellol methyl ether, citronellol ether, gingerol, shogaol, zingerone, capsaicin and capsaicine. According to the emulsion composition and a wet tissue applying emulsion composition, the preparation process is simple, and the cost is low; a plurality of feeling organs of the skin of a human body can be simulated; and compared with a product which only stimulates a single feeling organ of the human body, the emulsion composition has relatively long refreshing time.

The invention relates to the field of natural medicines, in particular to a method for preparing 6-shogaol, which is a method for preparing the efficient component 6-shogaol from the extract of ginger supercritical fluid. The method comprises the following steps of: mixing the extract of ginger supercritical fluid with an ethanol-containing acid water liquid before conversion, heating and refluxing, then separating and refining. The content of the 6-shogaol in the original extract of ginger supercritical fluid is about 2.5%, and the content of the 6-shogaol in the extract after the acid waterreaction can reach 20%.

The invention relates to a synthesis process of a gingerol derivative. A shogaol derivative is obtained by condensation of vanillin, aliphatic aldehyde and ketone in acid and base solvents in an appropriate ratio. The novel gingerol derivative is obtained by catalytic hydrogenation reduction of shogaol. The synthesis process disclosed by the invention is simple, and the gingerol derivative can be obtained through the reaction with one step-two steps and through a simple and convenient purification method.

The invention relates to the field of natural drugs, and discloses medical application of natural product 6-shogaol in enhancing the chemosensitivity of pancreatic cancer on gemcitabine and a compound drug composite of the natural product 6-shogaol. According to the invention, low-dose gemcitabine can generate biological effect under high dose through the combined administration of the 6-shogaol and the gemcitabine, so that the clinical usage amount of the gemcitabine can be greatly reduced, the toxic side effect can be reduced, the clinical treatment safety index can be enhanced, and good clinical application development prospect is achieved.

The invention discloses a processing method for fresh ginger. The processing method comprises the following steps that (1) cleansing is conducted, specifically, a fresh ginger raw material is taken, silt is washed away, and impurities are removed; (2) air is discharged, specifically, the cleansed fresh ginger is transferred into a steamer, and air and steam in the steamer are discharged; (3) closed steaming is conducted, specifically, the fresh ginger is subjected to closed steaming through the closed and air-discharged steamer under 100-130 DEG C for 2-4 h; (4) stewing is conducted, specifically, after closed steaming is completed, closed stewing is kept, the fresh ginger is naturally cooled, and then the steamer is opened; and (5) drying is conducted, specifically, the stewed fresh ginger is dried, and moisture is controlled to be 6%-13%. Through the specific fresh ginger processing method and technological parameters, dissolution of beneficial components in the fresh ginger is facilitated, the total content of gingerol is increased, gingerol components are promoted to be converted into shogaol components, the total content of shogaol is increased, the contents of water-soluble extracts and volatile oil are greatly increased, and meanwhile the color of a product is protected, so that the color appearance of the product is more excellent.

In accordance with the invention, an industrial process for producing shogaols useful in the fields of for example foods, flavor, pharmaceutical products, qui-pharmaceutical products and cosmetics can be provided. The invention relates to novel intermediates represented by the following general formula and a process for producing shogaols from the intermediates. In accordance with the invention, shogaols can readily be produced, of which mass production has been difficult because shogaols have been produced only by the extraction process from a natural ginger.

Intermediates;

(in the formula (1), R¹ represents hydrogen atom or methyl group; R² represents optionally branched alkyl group with one to 18 carbon atoms; R³ and R⁴ each independently represents hydrogen atom, a lower alkyl group or a protective group of the phenolic hydroxyl group; A represents an alkylene group with one to 4 carbon atoms; and X represents benzenesulfonyl group or toluenesulfonyl group.)

The present invention provides a pharmaceutical composition for preventing or treating learning disorders, memory disorders, Parkinson's disease, or ischemic cerebrovascular disease, which comprises a ginger extract or shogaol; and a pharmaceutically acceptable carrier. And also, the present invention provides a food composition for improving learning disorders or memory disorders or alleviating the symptoms of learning disorders or memory disorders which comprises a ginger extract or shogaol as an active ingredient, or a food composition for improving learning or memory which comprises a ginger extract or shogaol as an active ingredient.

The invention discloses a method for continuously extracting and purifying ginger polyphenol. According to the method, firstly, the ginger polyphenol is extracted in a combined way by an enzyme-ultrasound method; after the purification by an ultra-pure method, AB-8 macroporous resin adsorption is performed; then, a polyamide column, a silicon gel column and a Sephadex LH-20 gel column are continuously used for chromatography purification; the sample is subjected to freeze drying to obtain a purified sample. The maximum absorption wavelength of the polyphenol obtained from the ginger polyphenolpurified sample prepared by the method through UV scanning and CG-MS analysis is 281 nm; the result of the CG-MS analysis proves that the purified materials mainly contains 66.38 percent of 6-gingerol, 3.12 percent of 8-gingerol, 2.06 percent of Z-6-shogaol, 1.93 percent of 8-shogaol, 2.53 percent of citral and 9.35 percent of capraldehyde (heating degrading products of shogaol). The purity of the ginger polyphenol prepared by the method is as high as 85.37 percent.

The invention provides an extraction and purification method for 6-shogaol. The method comprises the following steps: taking fresh ginger and rhizoma zingiberis as raw materials; chopping the raw materials or adopting 70% ethyl alcohol for digesting in a 40-55 DEG C water bath after crushing; filtering drug residue and then performing reduced pressure distillation on the extracting liquid, thereby acquiring a concentrated solution; removing impurities by extracting the concentrated solution with petroleum ether and extracting 6-shogaol component by using ethyl acetate; after removing the solvent from the extracting liquid, performing chromatography with silica gel on the ethyl acetate extract part, adopting petroleum ether and ethyl acetate at ratio of (6:1)-(2:1) for performing gradient elution, separating and collecting the component of Rf=0.38 (petroleum ether and ethyl acetate at ratio of (3:1), thus obtaining the separated crude product of 6-shogaol; further thinning and performing chromatographic separation on the crude product of 6-shogaol, thereby acquiring pure product of 6-shogaol and representing the pure product with 1HNMR and 13CNMR. The method is simple in operation, the material cost is low, the time is saved and the purity is high. The acquired 6-shogaol product can be used as a standard product for quality control on the pharmaceutical preparation containing ginger and shogaol, pharmacological research, cosmetics, daily chemical products, and the like.

The invention discloses a marine antifouling nano paint, which is prepared from the following raw materials: epoxy phenolic resin, titanium dioxide, a nano biological antifouling agent, filler, an acetic acid, and glyceryl tristearate. Capsaicin in the nano-scale biological antifouling agent has a good approach-avoidance effect on marine organisms; tannic acid has an adhesion inhibition effect on barnacle and also has a paralysis function on the beetle; shogaol has strong ability of preventing adhesive ability of mussel. P-cinnamic acid sulfate has a strong adhesion inhibition effect on marine bacteria and barnacle, homarine can prevent adhesion of marine benthic diatom and barnacle, and diterpenes formamide has an effect of inhibiting the barnacle and shellfish larvae. The paint disclosed by the invention comprises a nano-scale pure natural biological antifouling agent, has the approach-avoidance effect on marine organisms, and destroys the adhesive ability of the marine organisms, so as to achieve the target of preventing and treating pollution. The marine antifouling nano paint does not generate any deleterious effect on the marine environment, is free of an injury to the marine organisms, and is purely natural and harmless.