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Pharmaceutical composition containing ginger extract or shogaol

A technology of ginger extract and composition, applied in the field of food compositions for improving learning ability or memory, can solve problems such as abnormal movement, abnormal autonomic nervous system or mental abnormality, drug side effects, etc., and achieve the improvement, improvement or learning of memory disorders. Disability, the effect of alleviating learning disabilities

Active Publication Date: 2011-10-12
UNIV IND COOP GRP OF KYUNG HEE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the long-term oral administration of these drugs leads to the problem of drug side effects
For example, anticholinergic agents may cause autonomic nervous system abnormalities or mental disorders, so continuous oral administration to elderly patients is limited
In addition, the effect of levodopa preparations gradually decreases with long-term oral administration, and side effects such as chorea-like and abnormal movements of involuntary movements of hands or feet occur.
Other surgical treatments such as neurostimulation using high frequency, i.e. high frequency release or deep brain stimulation, are available, but there are problems that invasive surgery is required and the cost is high

Method used

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  • Pharmaceutical composition containing ginger extract or shogaol
  • Pharmaceutical composition containing ginger extract or shogaol
  • Pharmaceutical composition containing ginger extract or shogaol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1. Preparation of ginger extract

[0071] After grinding 1 kg of ginger and adding 5 liters of ethanol and performing ultrasonic extraction for 1 hour, it was filtered and the filtrate was separated. The solid matter obtained by the filtration was again put into ethanol and subjected to ultrasonic extraction for 1 hour, and then filtered and the filtrate was separated again. The process was repeated 2 more times. The obtained filtrates were combined, concentrated under reduced pressure to remove the solvent, and then freeze-dried to completely remove water to obtain 200 g of ginger extract.

[0072] Add 1000 ml of distilled water to 200 g of the ethanol-extract obtained in the above steps to make the suspension uniform, then add 1000 ml of n-hexane and separate the n-hexane layer through a step-by-step separation process. The obtained n-hexane layer was concentrated under reduced pressure to remove hexane and dried by freeze-drying. This process was carrie...

Embodiment 2

[0073] Embodiment 2. Preparation of ginger extract

[0074] Ginger extract was prepared by supercritical extraction. Fill the ground and dried 200g ginger sample into a supercritical extractor, and extract twice at 300bar and 50°C for 6 hours each time. At this time, the flow rate of carbon dioxide is maintained at 30g / min, the pressure in the middle of the separator is set at 50-60bar, the temperature of the heating jacket at the upper end is set at 40°C, and the temperature of the cooling jacket at the lower end is set below 5°C. The gaseous carbon dioxide at the upper end of the separator passes through an activated carbon filter, is liquefied by a cooler, and then circulates to the extractor through a pump. As mentioned above, 4.32 g of ginger extract was obtained by performing supercritical extraction.

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Abstract

The present invention provides a pharmaceutical composition for preventing or treating learning disabilities, memory disorders, Parkinson's disease, or ischemic cerebrovascular disease, wherein said pharmaceutical composition contains ginger extract or shogaol and a pharmaceutically allowable carrier. Further, the present invention provides a food composition for improving or alleviating learning disabilities or memory disorders, or a food composition for improving learning ability and memory, containing ginger extract or shogaol as active ingredients.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for preventing or treating learning impairment, memory impairment, Parkinson's disease or ischemic cerebrovascular disease, the composition comprises ginger extract or shogaol, and a pharmaceutically acceptable carrier . The present invention also relates to a food composition for improving or alleviating learning impairment or memory impairment or a food composition for improving learning ability or memory, which contains ginger extract or shogaol as active ingredients. Background technique [0002] Memory refers to the process of absorbing new information or learning experience and knowledge from the surrounding environment, symbolizing and storing them in a specific part of the brain, and then recalling them (William F Ganong, Ganong's Physiology, Seoul, Han Yuli, p. 289 , pp. 291-292, 1999). The process of memory is divided into multiple stages of absorption, symbolization, strengtheni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P25/16A61P25/28A61P9/10A23L1/30A61K31/12
CPCA23L33/105A23V2002/00A61K31/12A61P9/10A61P25/00A61P25/16A61P25/28A23V2200/322A23V2250/21
Inventor 金善砺河相根柳钟薰吴明淑郑曙荣
Owner UNIV IND COOP GRP OF KYUNG HEE UNIV
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