41results about How to "Susceptible to drug resistance" patented technology

The invention relates to novel chloroethyl nitrosourea with anticancer activity and a synthesizing method thereof. The chloroethyl nitrosourea is a compound with a structure of the general formula (I), wherein n is an integer of 2 to 6. The chloroethyl nitrosourea can be used for treating gliomatosis cerebri, colon cancer and leukemia; compared with the existing nitrosourea-type anticancer medicine, the drug resistance is lower, the chemical therapy effect is better, the preparation method is simple in operation, the reaction yield is high, the toxicity is small, the cost is low, the method is suitable for the industrialized production, the development prospect is wide, and the application value is good.

The invention discloses a nauclea offcinalis extract, which is prepared by the following steps: grinding the nauclea offcinalis into coarse powder, feeding into an extraction kettle, adopting supercritical carbon dioxide to extract, and collecting extracts to obtain a supercritical extract; carrying out water extraction on the supercritical dregs, and condensing to obtain a water extract; combining and uniformly mixing the water extract and the supercritical extract to obtain the nauclea offcinalis extract; drying the nauclea offcinalis extract to obtain dried plaster powder, and preparing the dried plaster powder to the necessary dosage form. Additionally, the invention discloses an application of the nauclea offcinalis extract in treatment of pelvic inflammation. The invention has the following advantages: the prescription provided by the invention is more significant in treatment effect, the improved situation of the pelvic inflammation is better than a control group, thereby showing that the treatment effect of the prescription for the pelvic inflammation is better than that of the Western medicine metronidazole. Due to the fact that the pelvic inflammation is easy to relapse, so that the long-term medication is needed, but most Western medicines are based on antibiotic treatment, the side-effect is high and the drug resistance is easy to produce; however, the Chinese patent drug is low in the side-effect and suitable for the long-term medication, thereby being fitting for the characteristic that the pelvic inflammation is easy to relapse; and the prescription provided by the invention is appropriate for the long-term treatment of the pelvic inflammation.

The invention provides a CRISPR-Cas 9 system used for preventing and / or treating hyperlipidemia and other cardiovascular diseases and a preparing method and application thereof. The CRISPR-Cas 9 system comprises an sgRNA sequence of a specific region on a specific targeting human apo CIII gene and a middle carrier comprising the sgRNA sequence, and the specific region on the apo CIII gene is selected from apo CIII gene expressed regions. The invention further provides the application of the CRISPR-Cas 9 system to preparation of drugs for preventing and / or treating hyperlipidemia and other cardiovascular diseases. By means of the prepared sgRNA of the specific targeting human apo CIII gene, the human apo CIII gene can be targeted accurately and knocked out. The preparing method is simple in step, and good in sgRNA targeting, and the knockout efficiency of the CRISPR-Cas 9 system is high.

The invention discloses a traditional Chinese medicine tooth powder, comprising 9-17 parts of a Chinese medicine composition, 1.5-2 parts of a surfactant, 0.02-0.06 parts of a sweetener, 18-30 parts of a friction agent, and 0.02-0.08 parts of a spice; the Chinese medicine combination Herbs include 1.8-2.5 parts of Shegan, 2-3 parts of Hedyotis diffusa, 1-2 parts of walnut kernel, 0.2-0.5 parts of Cucumber, 0.2-0.3 parts of Scutellaria baicalensis, 0.1-0.2 parts of Polygonatum 0.1-0.2 parts, 0.5-1.5 parts of lotus root . The purpose of the present invention is to provide a kind of traditional Chinese medicine tooth powder, which is mixed with various Chinese herbal medicines and configured as a traditional Chinese medicine tooth powder. On the basis of cleaning teeth and preventing dental caries, it can clear away heat and detoxify, antibacterial, anti-inflammatory and analgesic, prevent oral ulcers, gingival bleeding, and protect throat. Sore throat and so on.

The invention discloses a Chinese medicine composition for treating toxoplasmosisinswine, and a preparation method and application thereof. The preparation method of the Chinese medicine composition disclosed by the invention comprises the following steps of: decocting four kinds of traditional Chinese medicines consisting of negundo chastetree leaves, Chinese wampee leaves, inonotus obliquus and liquorice by adding distilled water for 1-3 times, mixing decoctions, concentrating to be thick, adding ethanol with the concentration of 90-95% to adjust alcohol concentration to be 60-70%, precipitating, filtering, concentrating filtrate, adding ethanol with the concentration of 90-95% again into the concentrated liquid medicine to adjust alcohol concentration to be 75-80%, precipitating, filtering, concentrating filtrate, refrigerating and precipitating concentrated liquid medicine by adding distilled water, filtering, and concentrating to obtain liquid medicine. The curative rate of the Chinese medicine composition disclosed by the invention on toxoplasmosisinswine is above 85%; and the Chinese medicine composition has the advantages of low side effect and low use amount and is safe and convenient to use and rapid to absorb.