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Compound for inhibiting or killing helicobacter pylori

A technology of Helicobacter pylori and compound, applied in the field of compound preparation

Inactive Publication Date: 2019-01-11
霍卓平 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Compound for inhibiting or killing helicobacter pylori
  • Compound for inhibiting or killing helicobacter pylori
  • Compound for inhibiting or killing helicobacter pylori

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Experimental program
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Embodiment

[0017] We use the standard method widely used in the world, that is, the guidance scheme (NCCLS) proposed by the National Committee for Clinical Trials Standardization (NCCLS) for analysis and identification. By using the blood-containing Mueller-Hinton Broth medium to culture the obtained clinical drug-resistant Helicobacter pylori (Helicobacter pylori), and to detect the proliferation and survival of the compounds and their derivatives obtained by us, determine the compounds we are testing The minimum inhibitory concentration (Minimum Inhibitory Concentration, MIC) and the minimum bactericidal concentration (Minimum Lethal Concentration, MLC) of its derivatives. And compared with clinically commonly used anti-H. Moxicillin or metronidazole) have the same effect and are better than levofloxacin (levofloxacin). It shows that the combination of antibiotics commonly used in clinical practice can be replaced by novel compounds. The toxic and side effects of multiple antibiotics i...

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Abstract

The invention provides an application of a compound shown as a formula (I) to preparation of a medicine for inhibiting or killing helicobacter pylori and treating and preventing infection caused by the helicobacter pylori and related diseases of the helicobacter pylori. The compound provided by the invention is independently applied and can be used for killing the helicobacter pylori. A side effect caused by combined application of various antibiotics is avoided. In the formula, R1, R2 and R3 independently represent C1 to C8 alkyl, alkylidene and C2 to C8 alkyleneidene respectively. The R1, the R2 and the R3 independently represent aryl, isoaryl, or aryl or isoaryl which is randomly substituted through halogen, -CN, -NO2, -OH, -SH, -OR3, -SR3, -R3, -R3-OR4, -C(O)R3, -S(O)R3, -S(O)2R3, -NR4R5, -C(O)OR3, -C(O)NR4R5, -O(O)CR4, -S(O)CR4 and NR4(O)CR5 substituent groups.

Description

technical field [0001] The invention discloses a compound preparation, which is applied to the treatment and prevention of Helicobacter pylori infection and related diseases. Our research has found that this type of compound can kill Helicobacter pylori (Helicobacter pylori). The side effects caused by the combined application of multiple spectrum antibiotics are avoided. Accelerate the recovery of infectious diseases (gastric and duodenal ulcers and other diseases) caused by Helicobacter pylori. The application of this preparation will provide a new treatment means for the treatment of Helicobacter pylori infection and related diseases. Background technique [0002] Helicobacter pylori is a common human pathogen. It mainly invades the gastrointestinal tract of the human body, and is related to the pathogenesis of gastric ulcer, duodenal ulcer, chronic gastritis, and gastric cancer. According to epidemiological studies, about 50% of the world's population suffers from H...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/18A61K31/335A61P1/14A61P1/04A61P35/00A61P31/02
CPCC07D493/18A61P1/04A61P1/14A61P31/02A61P35/00
Inventor 霍卓平马治中
Owner 霍卓平
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