74 results about "Human pathogen" patented technology

Encoded metal nanoparticles conjugated to oligonucleotides, and methods for their use are described.

Recombinant human parainfluenza virus type 1 (HPIV1) compostions, formulations and methods are provided. The recombinant HPIV1 viruses and HPIV1 chimeric and chimeric vector viruses provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, and are useful in immunogenic composition s for eliciting an immune responses against one or more PIVs, against one or more non-PIV pathogens, or against a PIV and a non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HPIV1 genome or antigenome.

A composition and method of controlling oral and other human pathogens is disclosed. The composition and method utilize an antimicrobial or antibiotic and a berberine as active agents to treat mammals, including humans.

A computer implemented method for predicting the local area impact of the spread of global infectious diseases including the steps of providing on a computer readable medium a global pathogen risk factors database having data stored therein related to local area vulnerability of a group of human pathogens across a plurality of areas, providing on a computer readable medium a global pathogen activity database having data stored therein related to the activity of the group of human pathogens in said plurality of geographies, providing on a computer readable medium a global transport database having data stored therein related to travel patterns in and / or between the plurality of areas, processing by a computer system data on each of the global pathogen risk factors database, the global pathogen activity database and the global transport database to generate a pathogen vulnerability index, a pathogen activity index and a transportability index, and processing by the computer system each of the pathogen vulnerability index, the pathogen activity index and the transportability index to generate a risk indicator indicative of the local area impact of individual global infectious diseases.

Preservative compositions using toxicologically acceptable ingredients, and employing a pH of 9.0 or above for at least part of the process, for reducing the initial population and controlling the growth of spoilage bacteria and human pathogens and for preventing unwanted color changes in fresh and processed produce, particularly mushrooms. Aqueous solutions of preservatives are prepared and applied in multiple stages to the mushrooms, by spraying or immersion. More specifically, disclosed is a method for preserving fresh and processed mushrooms, comprising the steps of: contacting the mushrooms with an antimicrobial solution having a pH of about 9.0 or above; and rinsing the mushrooms one or more times immediately after the contacting step with pH-neutralizing solutions having a pH sufficient to return the produce to its physiological pH. In a preferred embodiment, electrolyzed basic water is used in the first stage high-pH rinse step and electrolyzed acid water is used in the second stage neutralizing solution step. Tyrosinase inhibitors such as ascorbates, erythorbates, EDTA or calcium chloride are added to the neutralizing solutions to inhibit enzymatic browning.

A method and a system for predicting the local area impact of the spread of global infectious diseases are provided. The system includes: providing a global pathogen risk factors database having data related to local area vulnerability of a group of human pathogens across a plurality of areas, a global pathogen activity database having data related to the activity of the group of human pathogens in the plurality of geographies, and a global transport database having data related to travel patterns in and / or between the plurality of areas. A method of processing data in each of the databases to generate a pathogen vulnerability index, a pathogen activity index and a transportability index to generate a risk indicator indicative of the local area impact of individual global infectious diseases.

The invention provides FIG. 1 novel antimicrobial chemical entities based on a nitrothiazolide backbone that exhibit antibacterial and antiparasitic action against a wide range of human pathogens. The new classes of compounds show extended action against Gram positive bacteria including MRSA drug resistant pathogens. In the Gram-positive organisms, they specifically target and functionally inhibit microbial attachment to surfaces and biofilm formation. In Gram-negative bacteria, including enteroaggregative E. coli strains, these compounds function as pilicides by inhibiting the assembly of pilin subunits into adhesive filaments. Several of these compounds show potent antimicrobial action against Gram positive bacteria, perhaps involving novel targets. Many of the benzothiophene derivatives exhibit antimicrobial activity in the low micrograms per ml range and in blocking biofilm formation in the nanomolar range; ranges considered are well within the range of utility as therapeutics.

The present invention provides isolated peptides relating to the autoimmune disease Pemphigus vulgaris. The peptides relating to Pemphigus vulgaris are self epitopes derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharmaceutical preparations for tolerizing and / or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharmaceutical preparations and methods of use for these epitopes are also provided.

A dry sanitizing patch for use in decreasing the transmission of one or more than one human pathogen, the dry sanitizing patch comprising: a) a binding layer comprising a fabric comprising one or more than one binding substance comprising one or more than one human pathogen binding group for chemically attaching the human pathogen to the binding substance; b) an adhesive layer connected to the binding layer, and comprising an adhesive suitable for reversibly attaching the dry sanitizing patch to a surface; and c) a backing layer removably connected to the adhesive layer to protect the adhesive layer until the patch is ready for use.

Almonds, other nuts, grains, dried or dehydrated fruits or vegetables, and other agricultural foodstuffs resting on a porous mesh conveyor belt (22, 54) pass continuously through a chamber (20, 60) in which they are contacted by a gaseous oxidizing agent at atmospheric pressure as the conveyor belt and food products move continuously through the chamber. In one embodiment, the chamber is disposed through a barrier (56) which isolates a raw product receiving region from downstream processing facilities to prevent cross-contamination downstream. In another embodiment, the chamber (20) is disposed through a barrier (34) which separates a husker (14) from a downstream Sheller (40) such that the shells are sanitized prior to releasing the nutmeats from the shells. In the preferred embodiment, the gaseous oxidizing agent is hydrogen peroxide at a 1.8 mg / liter concentration which flows up through the belt vibrating the food products without scarring them as the belt conveys the food products through the chamber for a duration of about 15 seconds to achieve a 3 log reduction in human pathogens.

The present invention relates a novel compound, chrysogenazine containing both indole and diketopiperazine ring systems, isolated from the chloroform fraction of the fermentation broth of Penicillium chrysogenum and the gross structure of the compound was elucidated by a detailed analysis of spectroscopic data (IR, NMR, MS), in addition, this invention also assesses the biological activity of the compound which reveals its antibacterial activity against the human pathogen, Vibrio cholerae, demonstrated by the disc diffusion assay.

The invention provides novel antimicrobial chemical entities based on a nitrothiazolide backbone that exhibit antibacterial and antiparasitic action against a wide range of human pathogens. The new classes of compounds show extended action against Gram positive bacteria including MRSA drug resistant pathogens. In the Gram-positive organisms, they specifically target and functionally inhibit microbial attachment to surfaces and biofilm formation. In Gram-negative bacteria, including enteroaggregative E. coli strains, these compounds function as pilicides by inhibiting the assembly of pilin subunits into adhesive filaments. Several of these compounds show potent antimicrobial action against Gram positive bacteria, perhaps involving novel targets. Many of the benzothiophene derivatives exhibit antimicrobial activity in the low micrograms per ml range and in blocking biofilm formation in the nanomolar range; ranges considered are well within the range of utility as therapeutics.

The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterized by having low levels, or no, PKR activity, or as being PKR− / −, STAT1− / − or both PKR− / − and STAT1− / −. The virus is selected from the group consisting of Rhabdovirus and picornavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.