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Special preparation of cnidium lactone for improving sarcopenia and muscle atrophy after fracture

A technology for osthole and muscle atrophy, which is applied to diseases of the muscular system, diseases of the neuromuscular system, medical preparations containing active ingredients, etc. Effects of academic use

Pending Publication Date: 2022-04-15
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

But large-scale trials are still needed to confirm the efficacy and safety of the appeal method, and the appeal method is considered limited

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  • Special preparation of cnidium lactone for improving sarcopenia and muscle atrophy after fracture
  • Special preparation of cnidium lactone for improving sarcopenia and muscle atrophy after fracture
  • Special preparation of cnidium lactone for improving sarcopenia and muscle atrophy after fracture

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Embodiment Construction

[0033] A snake bed is specially prepared to improve muscle lessons and fractures. The muscle atrophy is used to prepare the snake bed after improving muscle less and fracture muscle atrophy.

[0034] Snake bed special preparation method is: first dissolve the snake bed in DMSO, blow and mix, after the bedin is dissolved, add corn oil, an injection; put the oscillator, set the temperature 37.0 ° C, frequency 230R / min, 8h / overnight.

[0035] When the snake bed is dissolved in DMSO, 1% of the total capacity.

[0036] Snake bed, molecular formula: C15H16O3, molecular weight: 244.29, CAS number: 484-12-8.

[0037] The total calculation formula of the snake bed is:

[0038] Snake bed = 5mg / kg / d -3 * 10 * body weight G * n snake bed total = 5mg / kg / d -3 * 10 * Weight G * N

[0039] The total calculation formula of the total corn oil is:

[0040] Total corn oil = 60μL * N

[0041] Where N is only mice.

[0042] The method for improving the functional verification experiment of ...

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Abstract

The invention discloses special preparation of cnidium lactone for improving sarcopenia and muscular atrophy after fracture, belongs to the technical field of application of traditional Chinese medicines, and aims to improve sarcopenia and muscular atrophy after fracture after special preparation of fructus cnidii. A special preparation method of the fructus cnidii comprises the following steps: dissolving cnidium lactone in DMSO (dimethylsulfoxide), blowing, beating and uniformly mixing, and after the cnidium lactone is dissolved, adding the cnidium lactone into corn oil to prepare an injection; and putting into an oscillator, and setting the temperature to be 37.0 DEG C and the frequency to be 230r / min for 8 hours per night. The special preparation of the cnidium lactone provided by the invention has a biological effect of improving muscle, so that sarcopenia and muscle atrophy after fracture are treated.

Description

Technical field [0001] The invention belongs to the technical field of Chinese medicine applications, and specifically, a snake bed is specially prepared to improve muscle less and fracture muscle atrophy. Background technique [0002] Snake bed, also known as parsel phenol methyl ether, methoxy oil, s brain, also known as 7-methoxy-8- (3-methyl-2-butenyl) Cixooenin is a natural coumarin. According to modern pharmacological research, the most important active ingredients in traditional Chinese medicine alone, snake beds are snake beds. A large number of studies confirmed the wide pharmacological activity of snake beds in the human body, for example by inhibiting angiogenesis; anti-cancer activity; anti-hypertension, anti-aging, anti-inflammatory; liver protection, anti-asthma, anti-infection characteristics. However, there is a significant effect on muscle lessons. [0003] Muscle asciation is a carp of sexual and systemic skeletal muscle diseases involving muscle mass and functi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K47/44A61K31/37A61K36/234A61P21/00
Inventor 唐德志王拥军施杞金镇雄笪巍伟张岩赵永见舒冰王腾腾徐浩卢盛
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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