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Nauclea offcinalis extract and application of nauclea offcinalis extract for treating pelvic inflammation

A technology of extract and pelvic inflammatory disease, which is applied in the field of biliary wood extract and its application in the treatment of pelvic inflammatory disease, can solve the problems of patients not being able to obtain it, and achieve the effect of large and small side effects

Active Publication Date: 2012-10-24
广州海博特医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the lack of sufficient understanding of the pathogenesis of pelvic inflammatory disease, thousands of patients are left with a series of sequelae every year due to lack of timely and thorough treatment.

Method used

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  • Nauclea offcinalis extract and application of nauclea offcinalis extract for treating pelvic inflammation
  • Nauclea offcinalis extract and application of nauclea offcinalis extract for treating pelvic inflammation
  • Nauclea offcinalis extract and application of nauclea offcinalis extract for treating pelvic inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Grind the bile wood into coarse powder, put it into the extraction kettle, the pressure of the extraction kettle is 20MPa, the pressure of separation I is 9MPa, the pressure of separation II is 5MPa, the extraction temperature is 45°C, the temperature of separation I is 60°C, the temperature of separation II is 35°C, the extraction time For 2.5 hours, collect the extracts to obtain supercritical extracts for later use; add 8 times the amount of water to extract the supercritical medicinal residues twice, each time for 2 hours, filter, combine the second filtrates, and concentrate to a relative density of 1.05 -1.07 (60°C) to form a clear paste to obtain a water extract, combine the water extract with the supercritical extract, mix well, and dry to obtain a dry paste powder; the dry paste powder can be added with appropriate amount of auxiliary materials, mixed evenly, Granulate, compress into tablets, sub-package, and make tablets into medicines.

Embodiment 2

[0020] Grind the bile wood into coarse powder, put it into the extraction kettle, the pressure of the extraction kettle is 20MPa, the pressure of separation I is 9MPa, the pressure of separation II is 5MPa, the extraction temperature is 45°C, the temperature of separation I is 60°C, the temperature of separation II is 35°C, the extraction time For 2.5 hours, collect the extracts to obtain supercritical extracts for later use; add 8 times the amount of water to extract the supercritical medicinal residues twice, each time for 2 hours, filter, combine the second filtrates, and concentrate to a relative density of 1.05 -1.07 (60°C) to form a clear paste to obtain a water extract, combine the water extract with the supercritical extract, mix well, and dry to obtain a dry paste powder; add appropriate amount of auxiliary materials to the dry paste powder to granulate, pack into Capsules are subpackaged to prepare capsules as a finished medicine.

Embodiment 3

[0022] Grind the bile wood into coarse powder, put it into the extraction kettle, the pressure of the extraction kettle is 20MPa, the pressure of separation I is 9MPa, the pressure of separation II is 5MPa, the extraction temperature is 45°C, the temperature of separation I is 60°C, the temperature of separation II is 35°C, the extraction time For 2.5 hours, collect the extracts to obtain supercritical extracts for later use; add 8 times the amount of water to extract the supercritical medicinal residues twice, each time for 2 hours, filter, combine the second filtrates, and concentrate to a relative density of 1.32 -1.42 (60°C), forming a thick paste. Slowly add polysorbate, lanolin, sorbitol monopalmitate, and semi-synthetic fatty acid glycerides to the supercritical thickening cream, dissolve below 45°C, mix evenly, pour into suppository molds, cool down, and make suppositories. Divide into a suppository.

[0023] According to the clinical application, the extract of the b...

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Abstract

The invention discloses a nauclea offcinalis extract, which is prepared by the following steps: grinding the nauclea offcinalis into coarse powder, feeding into an extraction kettle, adopting supercritical carbon dioxide to extract, and collecting extracts to obtain a supercritical extract; carrying out water extraction on the supercritical dregs, and condensing to obtain a water extract; combining and uniformly mixing the water extract and the supercritical extract to obtain the nauclea offcinalis extract; drying the nauclea offcinalis extract to obtain dried plaster powder, and preparing the dried plaster powder to the necessary dosage form. Additionally, the invention discloses an application of the nauclea offcinalis extract in treatment of pelvic inflammation. The invention has the following advantages: the prescription provided by the invention is more significant in treatment effect, the improved situation of the pelvic inflammation is better than a control group, thereby showing that the treatment effect of the prescription for the pelvic inflammation is better than that of the Western medicine metronidazole. Due to the fact that the pelvic inflammation is easy to relapse, so that the long-term medication is needed, but most Western medicines are based on antibiotic treatment, the side-effect is high and the drug resistance is easy to produce; however, the Chinese patent drug is low in the side-effect and suitable for the long-term medication, thereby being fitting for the characteristic that the pelvic inflammation is easy to relapse; and the prescription provided by the invention is appropriate for the long-term treatment of the pelvic inflammation.

Description

technical field [0001] The invention relates to an extract of the Chinese herbal medicine dandelion and its therapeutic application, in particular to the extract of the eucalyptus extracted by supercritical carbon dioxide and its therapeutic application to pelvic inflammatory disease. Background technique [0002] Pelvic inflammatory disease (PID) refers to a clinical syndrome caused by infection of female pelvic genitalia above the cervix (including uterine body, fallopian tubes, and ovaries) and pelvic peritoneum and its adjacent connective tissue. Pelvic inflammatory disease mostly occurs in women who are sexually active and menstruating. Pelvic inflammatory disease rarely occurs in premenarchal, postmenopausal or unmarried women. If pelvic inflammatory disease occurs, it is often the spread of inflammation in adjacent organs. According to its pathogenic process and clinical manifestations, it can be divided into acute and chronic. Acute pelvic inflammatory disease refe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P15/00
Inventor 王帅帅严群超
Owner 广州海博特医药科技有限公司
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