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Method for clinically improving gastric cancer by TIL

A technology for gastric cancer and patients, applied in the field of immune cell therapy, can solve the problems of limited drug types and effects, and achieve the effect of treating many solid tumors, low side effects and strong curative effect

Pending Publication Date: 2020-10-30
卡替(上海)细胞生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Currently, the types and functions of targeted therapy drugs for gastric cancer are limited

Method used

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Embodiment Construction

[0017] The present invention will be described in detail below in conjunction with specific embodiments.

[0018] The invention discloses a method for clinically improving gastric cancer with TIL. The method is to separate and amplify lymphocytes in tumor tissues, cultivate mature TIL cells, and then reinfuse and inject TIL cells into gastric cancer patients for use in Improve the quality of life of gastric cancer patients. The method for clinically improving gastric cancer with TIL of the present invention specifically includes the following steps: patients with gastric cancer undergo surgery in a hospital, transport the removed tumor tissue to a GMP laboratory for subsequent processing and culture, and after 21 days of culture, mature the TIL cells , and then the TIL cells were transported back to the hospital and reinfused to patients with gastric cancer. The amount of TIL cells injected for each patient was 7×10 9 -7×10 12 indivual.

[0019] Improvement case: A 46-year-...

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Abstract

The invention discloses a method for clinically improving gastric cancer by TIL. The method comprises the following steps: separating lymphocytes from tumor tissues, amplifying the lymphocytes, culturing mature TIL cells, and injecting the TIL cells back to a gastric cancer patient for improving the living quality of the gastric cancer patient. The tumor infiltration lymphocyte disclosed by the invention has the advantages that tumor infiltrating lymphocytes are separated from a local part of a tumor by using a mechanical treatment and enzyme digestion method, high-dose IL-2 is added for in-vitro culture and transformation, and then the tumor infiltrating lymphocytes are subjected to autotransfusion into the body of the patient, so that compared with other immunotherapy, the tumor infiltrating lymphocytes have the advantages of multiple tumor antigen recognition targets, few side effects, multiple treatable solid tumors, stronger curative effects and the like. The TIL immunotherapy provided by the invention has efficient killing ability, can identify a plurality of antigen targets, uses autoimmune cells, has no side effect, and can be used for patients with recurrent or metastaticadvanced gastric cancer.

Description

technical field [0001] The invention belongs to the technical field of immune cell therapy, and in particular relates to a method for clinically improving gastric cancer with TIL. Background technique [0002] The causes of gastric cancer are: 1. Regional environment and dietary factors: There are obvious regional differences in the incidence of gastric cancer. The incidence of gastric cancer in the northwest and eastern coastal areas of my country is significantly higher than that in the south. The incidence of distal gastric cancer is high in people who eat smoked, roasted and salted foods for a long time, which is related to the high content of carcinogens or pre-carcinogens such as nitrite, mycotoxins, and polycyclic aromatic hydrocarbons in food; the risk of gastric cancer in smokers 50% higher than non-smokers. 2. Helicobacter pylori (Hp) infection: The Hp infection rate of adults in high-incidence areas of gastric cancer in my country is above 60%. Helicobacter pylo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/17A61P35/00A61P1/00C12N5/0783
CPCA61K35/17A61P1/00A61P35/00C12N5/0636C12N2501/2302C12N2509/00C12N2509/10
Inventor 李军
Owner 卡替(上海)细胞生物技术有限公司
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