The invention provides an efficient energy-saving type multi-mode enhanced denitrification sewage treatment system. The system comprises an anaerobic zone, an anoxic zone, an aeration zone I, a maneuvering zone, an aeration zone II, a rear anoxic zone and an aerobic zone which are connected in sequence, wherein a sludge regeneration area is arranged at the upper part of the anaerobic area; two water outlets are formed in the anaerobic zone and are respectively connected with the sludge regeneration zone and the anoxic zone; gates are arranged on the two water outlets to control the flow direction of water in the anaerobic zone; the aeration zone I and the aeration zone II are aerobic tanks or aeration anoxic tanks; and the maneuvering zone is an aerobic tank, an anoxic tank or an aerationanoxic tank. The system adopts a novel sewage treatment process developed on the basis of a traditional multi-stage AO process, and the core of the process is to combine an aeration anoxic process anda multi-stage AO process together, so that short-cut denitrification can be realized; and a plurality of water inlet points, multi-section backflow and precise aeration system control are arranged, so that sewage treatment systems in various modes can be formed, and different water outlet requirements can be met.