60results about How to "Stable and long-lasting drug effect" patented technology

The invention discloses a Chinese herbal medicine for treating fish diseases. The Chinese herbal medicine comprises the following raw materials by weight: 15-40g of andrographis paniculata, 15-60g of kusnezoff monkshood root, 15-40g of polygonum aviculare, 15-60g of rheum officinale, 15-40g of gallnut, 15-60g of acorus tatarinowii, 15-100g of folium artemisiae argyi, 15-40g of radix glycyrrhizae, 15-60g of herba schizonepetae, 15-60g of radix angelicae dahuricae, 15-60g of pulsatilla chinensis regel, 15-60g of chrysanthemum indicum, 15-40g of honeysuckle, 15-40g of rhizoma coptidis, 15-60g of poria cocos, 15-40g of corn mint, 15-60g of wild pepper, 15-60g of fructus kochiae, 15-100g of sophora flavescens, 15-60g of cortex acanthopanacis, 15-40g of philippine violet herb, 15-60g of cortex erythrinae, 15-40g of semen arecae, 15-60g of dandelion, 15-60g of mulberry twig and 200-400g of fresh pine needle.

The present invention discloses a preparation method of acarid-resisting anti-bacterial cellulose fiber. Said cellulose fiber is made up by adopting cellulose spinning dope containing acarid-resisting anti-bacterial agent through the processes of spinning, non-oxidative desulphurization and drying at 120 deg.C. The acarid-resisting anti-bacterial agent content in the spinning dope is 1-10%.

The invention discloses a traditional Chinese medicine warm-moxibustion bag and relates to the field of healthcare traditional Chinese medicine bags. According to the technical scheme, the traditional Chinese medicine warm-moxibustion bag comprises the following components in percent by weight: 40%-80% of mineral salt and / or magnet and 20%-30% of Chinese herbal medicines. The traditional Chinese medicine warm-moxibustion bag is characterized in that the Chinese herbal medicines are one or more of semen cassia, radix angelicae, mint, radix sileris, schisandra chinensis, white chrysanthemum, albizia flower, tuber fleeceflower stem, silkworm droppings, notopterygium root, root of red-rooted salvia, borneol, raw dens draconis, raw keel, dried tangerine or orange peel, carcuma longa, wintergreen, radix angelicae pubescentis, Chinese angelica, radix paeoniae alba, folium artemisiae argyi, radix paeoniae rubra, radix bupleuri, cinnamon, peach kernel, rhizoma zingiberis, frankincense and myrrh. The warm-moxibustion bag disclosed by the invention is free of harms on body and high in safety, and has the effects of promoting sleep, promoting blood circulation, warming uterus, promoting metabolism, relieving fatigue, expelling wind and removing cold and relieving pain. And meanwhile, the traditional Chinese medicine warm-moxibustion bag is convenient to apply, does not need spraying clear water, is stable and lasting in pharmaceutical effect, and has the effects of treating diseases, preventing diseases, and cultivating life and preserving health.

The invention discloses a planting method of tartary buckwheat rich in gamma-aminobutyric acid and dietary fibers. The planting method includes the steps: firstly, performing fine soil preparation, plowing deep and sunning the upturned soil, sufficiently applying base fertilizers, plowing, raking and forming irrigation and drainage ditches; secondly, sprouting buckwheat by conventional technology for 24-48 hours, soaking the sprouted buckwheat in 1-5% salt solution for 1-3 hours and then seeding; thirdly, performing field management including cultivating and weeding, and cultivating and ridging; fourthly, performing supplementary pollination; fifthly, preventing disease and pest injury and timely harvesting the tartary buckwheat. The content of the gamma-aminobutyric acid and the dietary fibers in harvested tartary buckwheat grains is obviously higher than that of common tartary buckwheat, fruits are completely filled, the tartary buckwheat is fine in quality and high in yield, economic benefits are obviously improved, and the planting method has an important significance for high added value production and popularization.

The invention discloses an externally-applied traditional Chinese medicine composition, an externally-applied traditional Chinese medicine preparation as well as a preparation method and application of the externally-applied traditional Chinese medicine composition. The externally-applied traditional Chinese medicine composition is prepared from the raw materials comprising the following components in parts by weight: 30-70 parts of semen brassicae, 15-60 parts of euphorbia kansui, 60-180 parts of sabia japonica, 30-70 parts of rhizoma corydalis and 15-60 parts of asarum. The traditional Chinese medicine composition disclosed by the invention has the efficacies of warming and activating meridians to stop pain, resisting inflammation, reducing swelling and easing pain to improve the symptoms of chronic pain, combines acupoint stimulation with chemical action of drugs through moxibustion when applied to acupuncture and moxibustion therapy, plays a role in easing pain and reducing inflammation by moxibustion therapy, and can be used for enhancing the curative effect of an externally-applied drug. In addition, the externally-applied traditional Chinese medicine composition is an externally-applied preparation; the first-pass effect of a toxic drug is relieved by transdermal absorption; the target of treating the pain is realized; and meanwhile, the dosage of the drugs is reduced, so that the safe and effective targets are realized.

The invention relates to a method for preparing drugs for treating hypertension employing dendrobium officinale and semen raphani as main materials. The method comprises the steps of grinding fried semen raphani, radix ophiopogonis and a white peony root into powder, mixing evenly, heating the mixture, extracting and concentrating to obtain a water extract concentrate; grinding dendrobium officinale into powder, adding the powder to the water extract concentrate; and adding auxiliary materials for molding; or grinding the four medicinal materials into powder and then carrying out alcohol extraction: adding 5fold 75% ethanol for extracting at 60 DEG C for 24h, carrying out extraction twice in all and recovering the ethanol; after alcohol extraction, carrying out water extracting treatment on residues, concentrating and merging the alcohol extraction solution and the water extraction solution; and adding the auxiliary materials for molding. The prepared drugs all are suitable for treatment of patients with hypertension, caused by a yin-deficiency syndrome or a yin-deficiency and yang-predominance syndrome, accompanied by restlessness and insomnia, or all are combined with antihypertensive drugs of the Western medicine for treatment to reduce the dosage of the antihypertensive drugs of the Western medicine. Meanwhile, the drugs are suitable for health use of patients with mild hypertension or normal hypertension.

The invention relates to a mosquito repellent gel containing sedum sarmentosum and mint oil and a preparation method thereof, belonging to the field of pharmaceutics. Based on the combination of sedum sarmentosum with detoxifying, swelling reducing, antibacterial and insect repelling effects and mint oil with cooling and itching and pain relieving effects, the invention provides a gel and the preparation method and production technology of the gel. The preparation method comprises the following steps of sedum sarmentosum filtered juice preparation, uniform mixing, matrix preparation, pH value regulation, sterilizing and finished product preparation and the like. The gel has mosquito repelling, itching relieving and antibacterial functions, is natural, safe, harmless and portable, can be absorbed quickly, has stable and long-lasting pesticide effect; the utilization rate of medical materials is improved, medical demands are met and the clinic application of the medical materials is widened.

The invention belongs to the field of medicines and in particular relates to an ointment capable of controlling mosquito bite and a preparation method thereof. The ointment capable of controlling mosquito bite comprises the following raw materials in parts by weight: 50-120 parts of folium artemisiae argyi, 40-90 parts of Radix angelicae dahurioae, 30-80 parts of purslane, 40-90 parts of lotus leaf, 30-80 parts of glycerin, 110-160 parts of liquid paraffin, 100-140 parts of stearic acid, 5-14 parts of triethanolamine and 300-600 parts of water. The ointment capable of controlling mosquito bite prepared from the raw materials by using the preparation method is gentle and low in sensibility, has an effect of rapidly relieving itching and reducing swelling, and mosquito bite can be prevented and treated.

The invention relates to an amlodipine crystal, a medicine composition of the amlodipine crystal and benazepril as well as a method for preparing the medicine composition. The amlodipine crystal is a maleic acid amlodipine hydrate crystal, which has a molecular formula as follows: C20H25C12N2O5.C4H4O4.1.5H2O. The medicine composition comprises the following compositions in parts by weight: 2.5-10parts of amlodipine crystal, 10-20 parts of benazepril, 5-50 parts of compressible starch, 20-60 parts of microcrystalline cellulose, 15-40 parts of low-substitution hydroxypropylcellulose, 1-8 partsof sodium carboxymethyl starch, and 1-3 parts of magnesium stearate. The amlodipine in the medicine composition works fast and stably, and can release efficacy stably within 24 hours; and the medicine composition has strong synergism, accumulation and complementary actions, and high bioavailability.

The invention discloses a plaster for treating dysmenorrhea. The plaster is prepared from the following medicinal materials in parts by weight: 12-14 parts of radix angelica sinensis, 12-14 parts of fructus chaenomelis, 9-11 parts of radix aconiti carmichaeli, 6-8 parts of trogopterus dung, 13-15 parts of cortex cinnamomi, 9-11 parts of myrrh, 9-11 parts of rhizoma zingiberis, 9-11 parts of the root of three-nerved spicebush, 4-7 parts of herba verbenae, and 8-10 parts of folium artemisiae argyi. The plaster aims at the woman primary dysmenorrhea and secondary dysmenorrhea, has the efficacies of regulating menstruation and dispelling cold, warming the uterus, promoting the blood circulation to remove blood stasis, soothing the liver and regulating the circulation of qi, and relieving pain, is simple in treatment, and is convenient to use. The plaster has good curative effects for the cold-congealing and blood-stagnating dysmenorrhea, and the dysmenorrhea caused by liver qi stagnation, blood deficiency complicated with stagnancy, and qi-blood deficiency complicated with stagnancy, is reasonable in formula, wide in applications, free of toxic and side effects and untoward effects, and durable and stable in efficacy, and belongs to a special-effect functional medicine for treating dysmenorrhea.

The invention relates to an externally applied Mongolian drug powder for treating leukoplakia vulvae and a preparation method thereof, which pertains to the technical field of medicine, the powder is composed of 8 pure natural high-quality Mongolian medicines, the names and the percentages thereof are as follows: 10 to 20 percent Guguri, 10 to 20 percent Hulidoushunqiqige, 10 to 20 percent Marushe, 10 to 20 percent Temuriaoliyanggu, 10 to 20 percent Barula, 5 to 10 percent Errialatanjiguri, 5 to 10 percent Harimaogai and 5 to 10 percent Wurileheqiqige. The medicines are respectively selected and weighed according to the percentages, part of the medicines are firstly carried out the concoction and other treatments according to the specific process requirements and then are evenly mixed, smashed or ground, etc. for preparation, thus having various effects of activating blood circulation, removing blood stasis, promoting fluid production, reliving itch, anti-bacterial, anti-inflammatory,reducing pain, detumescence, enhancing skin blood circulation, effectively promoting skin elasticity, etc., the efficacy is significant, the total effective rate is as high as 98.95 percent; and the powder is characterized by rapid efficacy, simple and easy production, low cost, convenient carrying and usage, lasting efficacy and no toxicity or side effects, etc.

The invention belongs to the technical field of drug sustained release preparations, and particularly relates to an edoxaban-containing sustained release preparation and a preparation method thereof. The sustained release preparation consists of a quick release layer and a sustained release layer, wherein the quick release layer mainly consists of an edoxaban solid dispersion, a disintegrating agent, a filling agent and a lubricating agent; the sustained release layer is mainly composed of an edoxaban bulk drug, a sustained-release material, a filler, a lubricant and an adhesive. The sustained release preparation containing edoxaban, which is excellent in controlled release effect and high in dissolution stability, is provided by optimizing the types, the proportion and the dosage of the filling agent and the sustained release material and optimizing the preparation method of the edoxaban solid dispersion in the process, and the problems that a sustained release preparation containing edoxaban is poor in release effect, low in dissolution rate and the like are solved.

The present invention discloses a natural environmentally-protective air sterilizing and mosquito dispelling preparation, including the following raw materials in parts by weight: 40-60 parts of distilled water, 30-50 parts of wormwood essential oil, 20-40 parts of telosma cordata essential oil, 10-30 parts of rose oil, 10-30 parts of lavandula angustifolia essential oil, 10-30 parts of menthol crystals, 10-20 parts of antibacterial agent, 10-20 parts of sublimation agent, 8-12 parts of pelargonium graveolens oil and 5-9 parts of ethylparaben. The natural environmentally-protective air sterilizing and mosquito dispelling preparation has advantages of being natural, safe, harmless and stable and lasting in drug efficacy and is low in production cost, easy to use and wide in application scope.

The invention discloses an external use type traditional Chinese medicine composition, and an extract, preparation and application thereof. The external use type traditional Chinese medicine composition is prepared from, by weight, 3-30 parts of semen cuscutae, 1.5-15 parts of fructus psoraleae, 3-30 parts of folium artemisiae argyi, 0.5-5 parts of cortex cinnamomi and 1-10 parts of rhizoma chuanxiong. The composition can treat both symptoms and root causes through acupoint application and transdermal absorption, stomachache caused by cold in uterus can be treated comprehensively, cold in uterus is relieved fundamentally, and therefore stomachache caused by cold in uterus is improved. The external use type traditional Chinese medicine composition can also be combined with mild moxibustion for indirect moxibustion treatment, so that fast relief and treatment of stomachache can be achieved, using is convenient, gastrointestinal tract side effects of drugs are avoided, and influences on hepatic and renal functions are reduced.

The invention discloses a feed suitable for grass carp culture and a preparation method thereof, and belongs to the technical field of feed. The feed is prepared from the following raw materials by weight: 10-20 parts of pork powder, 10-20 parts of corn flour, 10-20 parts of bean curd residues, 10-20 parts of soybean powder, 10-20 parts of fish bone meal, 10-20 parts of broad bean powder, 5-10 parts of rapeseed meal, 0.1-0.3 part of Chinese herbal medicine powder, 3-5 parts of a microbial preparation and 2-5 parts of polylactic acid / glycolic acid nano microspheres. The added nano microspheresto make the Chinese herbal medicine powder have stable and durable effects, greatly reduce the use amount of the Chinese herbal medicines; and at the same time, the use of the microbial preparation can improve the immunity of the grass carp, and improve the meat quality of the grass carp while increasing the yield. The formula of the invention is reasonable, the dosage is accurate, and the damageto the nutrient environment of the water body is greatly reduced; and the preparation process is simple, convenient in operation, and remarkable in the effects.

The invention discloses a prescription for treating a red skin disease. The treating prescription comprises the following components of: sodium chloride, potassium permanganate, streptomycin sulfate, diatomite, chitin and water. The prescription for treating the red skin disease has ideal curative effects on the red skin disease, and the main components of the prescription are natural materials without toxicity or side effects. the prescription has the characteristics of good biocompatibility, stable and durable curative effects, wide raw material source and low cost.

The invention discloses a planting method of cactus. The planting method is characterized by comprising the following steps: (1) planting; (2) watering; (3) preparing a culture solution; (4) applying fertilizers; (5) preparing a fungicide to be sprayed. The culture solution is used in the earlier stage, so that cactus is stable in production, the capability resistance of cactus is improved, the botanical fungicide, which has high bacteriostatic activity and is stable and lasting in drug effect, environmental-friendly and convenient to use, is added, so that the disease resistance of the plant is strong, and the obtained plant is beautiful in plant type, glossy in leaf, and not infected by other diseases. The planting method is low in production cost, and the culture method is simple and convenient, and is suitable for popularization and application.

The invention relates to the field of Chinese patent medicines, and in particular relates to a pharmaceutical composition for treating impotence and premature ejaculation. Each 100ml of pharmaceutical composition is prepared from the following components by weight: 200-250g of maca, 10-34g of cistanche salsa, 10-30g of wolfberry fruits, 6-13g of radix ginseng rubra and 10-15g of ginkgo seeds. With the maca as a main raw material, the pain caused by impotence and premature ejaculation of men is avoided; and the pharmaceutical composition, which is good in curative effect, safe and free of a side effect, and the production method thereof are provided.

The invention belongs to the field of medicine, and particularly relates to a wormwood-extract-containing itch-relieving ointment and a preparation method thereof. The wormwood-extract-containing itch-relieving ointment comprises the following raw materials in parts by weight: 50-60 parts of wormwood extract, 20-25 parts of Moringa oleifera leaf, 25-30 parts of honeysuckle flower, 40-60 parts of glycerol, 130-140 parts of liquid paraffin, 110-120 parts of stearic acid, 8-10 parts of triethanolamine and 500-650 parts of water. The wormwood-extract-containing itch-relieving ointment, which is prepared from the raw materials above by the preparation method, is mild and hypoallergenic, can quickly relieve itching and resist inflammation, can effectively kill and inhibit bacteria, and can be used for treating cutaneous pruritus for children.

The invention discloses a medicine for treating gastrointestinal diseases. The medicine for treating the gastrointestinal diseases comprises the following components in part by weight: 5-15 parts of licorice, 10-20 parts of Bletilla striata, 5-15 parts of Astragalus, 10-20 parts of Atractylodes, 3-15 parts of Angelica, 3-10 parts of pharbitis seed, 1-5 parts of plantain, 5-15 parts of Bupleurum, 5-10 parts of rhizoma corydalis and 10-20 parts of fructus aurantii. The medicine for treating the gastrointestinal diseases is fast to take effect, good in therapeutic effect, stable and lasting in medicinal effect and easy to prepare, has the functions of removing dampness and treating stranguria, clearing heat and removing toxicity, excreting dampness and stopping diarrhea and the like, can treat stomach diseases and intestinal diseases, and is free of toxic side effect and good in safety.

The invention discloses novel compound anticoccidial soluble powder and a preparation method thereof. According to the compound preparation disclosed by the invention, the problem of water solubility of trimethoprim medicine is changed by adopting a special process, the soluble powder is prepared, and the bioavailability is improved through drinking water administration; based on the cooperation of the trimethoprim and sulfachloropyrazine sodium, folic acid metabolism of coccidiosis can be blocked at the same time from two different links to achieve a synergistic effect. The TMP belongs to a sulfonamide synergistic drug, wherein the mechanism research shows that the TMP can obviously improve the anticoccidial index by being combined with sulfachloropyrazine sodium, the sulfachloropyrazine sodium and trimethoprim soluble powder is stable in drug property and exact in clinical test curative effect, the anticoccidial index of a single drug is obviously improved through combined drug use, and the drug use period is shortened, Therefore, revolutionary significance is realized on the treatment of coccidiosis diseases.

The invention belongs to the technical field of a medical and dental formula product, and especially relates to a paste for treating pulpitis and an application thereof. The paste is composed of glycerin iodohydrin, iodoform, glutaraldehyde, an oily substrate, and calcium hydrate, wherein the volume ratio of glycerin iodohydrin to iodoform to glutaraldehyde to the oily substrate is 3-4:1-2:1-2:3-4, the proportion of the oily substrate to calcium hydrate is ml:g being 1:4-6, and the above components are mixed and a mixture is blended to obtain the paste for treating pulpitis. The paste for treating pulpitis has active effect for preservation and treatment of vital pulp-teeth, and avoids nerve injury after dental pulp exposing, denervation, and root canal therapy, so that pain for treatmentcan be alleviated, dental pulp tissue inflammation diminishing is promoted, and restoration and regeneration are realized.

The invention discloses a plant-sourced synergic compound insecticide containing tea polyphenol and dioscin and a preparation method of the plant-sourced synergic compound insecticide. The preparation method comprises the steps of adding auxiliaries into tea polyphenol and dioscin, wherein tea polyphenol and dioscin are used as main components; and compounding to obtain the plant-sourced synergic compound insecticide. The preparation is environment-friendly emulsified oil or emulsion in water; and the preparation contains 1.0-10.0% of tea polyphenol, 20.0-50.0% of dioscin and the balance of the auxiliaries. The insecticide contains no any chemical pesticide components, is nontoxic to people and livestock, environment-friendly and incapable of easily generating drug resistance of insects, is easily degraded and is mainly applied to prevention and control of aphid diseases such as cotton aphid, macrosiphoniella sanborni, macrosiphum rosivorum and aphis citricola on flowers so as to have extremely high application and popularization values, so that the insecticide an ideal novel pollution-free insecticide.

The invention discloses a fatty acid milk preparation and a preparation method thereof, which relate to the technical field of food preparation, and solves the problem that fish oil in fat milk is prone to aging and causes great harm to the human body during use. The fatty acid milk preparation comprises the following components by weight percentage: 80-85% of refined fish oil; 0.5-0.9% of an antioxidant; 1.5-2.5% of an emulsifier; 2-3% of a flavoring agent; 2.5-4.5% of mixed rubber; 1.8-2.4% of vitamin E; 0.8-1.6% of lecithin; 0.1-0.2% of sodium benzoate; 1.2-1.8% of glycerol; and the balanceof deionized water. The fish oil in the fatty acid milk preparation of the invention is not easily oxidized, so that the fatty acid milk preparation is not easy to cause great harm to the human bodyin actual use, and has good use effect.

The invention discloses a water dispersible granule composition containing fluxapyroxad, diethyl aminoethyl hexanoate and tebuconazole, and application of the water dispersible granule composition. The water dispersible granule composition comprises the following components in weight content: 1 to 50 percent of a component A and 1 to 50 percent of a component B. The component A comprises fluxapyroxad and diethyl aminoethyl hexanoate in the ratio of 5 to 1, and the component B comprises tebuconazole. The bactericidal composition adopts water dispersible granule as a formulation, and is high in disintegration speed, good in dispersing performance, high in suspension rate and used for mist spraying. The formula of the water dispersible granule composition improves the pesticide effect and bacteriocidal spectrum through the reasonable rational combination of fluxapyroxad, diethyl aminoethyl hexanoate and tebuconazole, has obvious synergistic effect, reduces the dosage, and promotes plants to be strong and lodging-resistant. The water dispersible granule can be applied to crops, such as cucumbers, bananas, strawberries, grapes, wheat, oilseed rapes and paddies, and has a good control effect on powdery mildew and downy mildew of cucumber, venturia inaequalis, leaf spot and sclerotinia sclerotiorum of banana, grey mould fruit rot of strawberry and powdery mildew of grape.

The invention discloses a preparation method of an algae culture fertilizer containing Chinese herbal medicines. The preparation method comprises the steps of crushing the Chinese herbal medicines, adding water, carrying out microwave extraction, filtering, adding an organic solvent into the filtrate, removing the filtrate, concentrating to obtain a Chinese herbal medicine preparation, adding sodium humate, potassium fulvate, bamboo vinegar liquid, microelements and attapulgite, uniformly mixing, granulating, and drying, so as to obtain the algae culture fertilizer, wherein the organic solventfor precipitating the Chinese herbal medicines contains ethanol, sodium usnic acid and sodium butyrate. The preparation method provided by the invention has the advantages that the production energyconsumption is low, particles are rapidly formed, the raw material utilization rate is high, and the production efficiency is high; and prepared algae culture fertilizer particles are high in yield offinished products, good in stability and capable of optimizing the algae phase and rapidly fertilizing and purifying water.

The invention discloses a compound aloe barbadensis polysaccharide topical gel used for treating burn. 1000 weight parts of raw materials of the compound aloe barbadensis polysaccharide topical gel used for treating burn are prepared from, by weight, 20-80 parts of main drugs, 30-50 parts of matrixes, 10-90 parts of a moisture preserving agent, 1-5 parts of triethanolamine and the balance a phosphate buffer solution. The main drug is prepared from aloe barbadensis extracts or one or a combination of aloe barbadensis extracts, nano silver powder and nano zinc powder. The compound aloe barbadensis polysaccharide topical gel used for treating burn has the advantages of being green, natural, safe and harmless, remarkable in burn treating effect, capable of being fast absorbed, stable and lasting in medicine effect, convenient to carry and transport, and the like, the utilization rate of Traditional Chinese medicine material resources is increased, the medical requirement is met, and the purpose of widening clinical application of the compound aloe barbadensis polysaccharide topical gel used for treating burn is achieved.

The invention relates to an external Mongolian drug paste for curing the infantile anorexia and a preparing method thereof, which belong to the pharmacological science technology field. The 'dou ri xi li tai' recipe of the invention is prepared by four pure natural herbs, which is external powder, has the functions of improving appetite, assisting digestion, stimulating appetite and increasing immunologic function, and the invention includes ingredients by the weight percentages as follows: 20 to 30 percent of unyi ritu nonggu gayin wuri, 20 to 30 percent of shebushe geriqi gana, 20 to 30 percent of garensa and 20 to 30 percent of huli sencha heirima. The preparing process has the following steps that the four drugs are optimized and are respectively weighed in proportion, the huli senchaheirima is dried in sunlight after being dunked in boiled water, then the four drugs are uniformly mixed, at last are smashed or ground into -60 meshes powder, 3 to 6 g of powder is taken each time, and mixed with tea to the paste form for sticking.

The invention belongs to the technical field of drug sustained-release preparations, and in particular relates to a sustained-release preparation containing edoxaban and a preparation method thereof. The sustained-release preparation is composed of an immediate-release layer and a sustained-release layer, wherein the immediate-release layer is mainly composed of edoxaban solid dispersion, a disintegrant, a filler, and a lubricant; the sustained-release layer is mainly composed of edoxaban bulk drug, sustained-release release materials, fillers, lubricants and binders. The present invention provides an edoxaban-containing drug with excellent controlled release effect and high dissolution stability by optimizing the type and proportion of the filler, the sustained-release material, and the preparation method of the edoxaban solid dispersion in the optimized process. The sustained-release preparation solves the problems of poor release effect and low dissolution rate of the edoxaban sustained-release preparation.