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Method for preparing drugs for treating hypertension employing dendrobium officinale and semen raphani as main materials

A technology of Dendrobium officinale and high blood pressure is applied in the field of drug preparation, which can solve the problems of insufficient blood pressure reduction, insufficient curative effect and the like, and achieve the effects of being conducive to rapid reduction, blood pressure, and restoring the balance of lifting and lowering.

Active Publication Date: 2017-10-20
HANGZHOU DANHE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems that the reduction of blood pressure is not obvious enough in the near future after taking the medicine, the number of medicines has too many flavors to contain each other or offset the effect, and the medicine composition, extraction, preparation process, etc. have not been systematically optimized, so the curative effect cannot meet the requirements, and it is difficult to be practical in clinical practice. Value

Method used

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  • Method for preparing drugs for treating hypertension employing dendrobium officinale and semen raphani as main materials
  • Method for preparing drugs for treating hypertension employing dendrobium officinale and semen raphani as main materials
  • Method for preparing drugs for treating hypertension employing dendrobium officinale and semen raphani as main materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 2.5 parts of Dendrobium candidum, 2.5 parts of fried raisin seed, 2.5 parts of Ophiopogon japonicus, 2.5 parts of white peony

[0036] Take 250g of Dendrobium officinale, 250g of fried raisin seed, 250g of Ophiopogon japonicus, and 250g of white peony that comply with the 2015 edition of the Chinese Pharmacopoeia. Stir-fried scutellaria, Ophiopogon japonicus, and white peony powder, add 12 times the amount of water and heat for 2 hours, extract twice, and concentrate to 500g. The medicinal materials of Dendrobium candidum are ground into fine powder, and the above-mentioned fried raisin, Ophiopogon japonicus, and white peony water are added to extract the concentrated liquid, and the mixture is stirred evenly to make a soft material, and then a pill. Dry at 70 degrees. It is the sample of Example 1. Orally, the daily dosage for adults is equivalent to 10g of crude drug (can be as large as 30g).

Embodiment 2

[0038] 10 parts of Dendrobium candidum, 20 parts of fried scallions, 10 parts of Ophiopogon japonicus, 10 parts of white peony:

[0039] Take 200g of Dendrobium officinale, 400g of fried raisin seed, 200g of Ophiopogon japonicus, and 200g of white peony root that comply with the 2015 edition of the Chinese Pharmacopoeia. Stir-fried scutellaria, Ophiopogon japonicus, and white peony powder, add 12 times the amount of water and heat for 2 hours, extract twice, and concentrate to 500g. The medicinal materials of Dendrobium candidum are ground into fine powder, and the above-mentioned fried raisin, Ophiopogon japonicus, and white peony water are added to extract the concentrated liquid, and the mixture is stirred evenly to make a soft material, and then a pill. Dry at 70 degrees. It is the sample of Example 2. Oral, the daily dosage for adults is equivalent to 50g of crude drug (can be as small as 10g).

Embodiment 3

[0041] 15 parts of Dendrobium candidum, 60 parts of fried raisin seeds, 15 parts of Ophiopogon japonicus, 15 parts of white peony:

[0042] Take 142.86g of Dendrobium officinale, 571.43g of fried scutellaria, 142.86g of Ophiopogon and 142.86g of Radix Paeoniae Rubra that comply with the 2015 Chinese Pharmacopoeia. Stir-fried scutellaria, Ophiopogon japonicus, and white peony powder, add 12 times the amount of water and heat for 2 hours, extract twice, and concentrate to 500g. The medicinal materials of Dendrobium candidum are ground into fine powder, and the above-mentioned fried raisin, Ophiopogon japonicus, and white peony water are added to extract the concentrated liquid, and the mixture is stirred evenly to make a soft material, and then a pill. Dry at 70 degrees. It is the sample of Example 3. Oral, the daily dosage for adults is equivalent to 105g of crude drug (can be as small as 10g).

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Abstract

The invention relates to a method for preparing drugs for treating hypertension employing dendrobium officinale and semen raphani as main materials. The method comprises the steps of grinding fried semen raphani, radix ophiopogonis and a white peony root into powder, mixing evenly, heating the mixture, extracting and concentrating to obtain a water extract concentrate; grinding dendrobium officinale into powder, adding the powder to the water extract concentrate; and adding auxiliary materials for molding; or grinding the four medicinal materials into powder and then carrying out alcohol extraction: adding 5fold 75% ethanol for extracting at 60 DEG C for 24h, carrying out extraction twice in all and recovering the ethanol; after alcohol extraction, carrying out water extracting treatment on residues, concentrating and merging the alcohol extraction solution and the water extraction solution; and adding the auxiliary materials for molding. The prepared drugs all are suitable for treatment of patients with hypertension, caused by a yin-deficiency syndrome or a yin-deficiency and yang-predominance syndrome, accompanied by restlessness and insomnia, or all are combined with antihypertensive drugs of the Western medicine for treatment to reduce the dosage of the antihypertensive drugs of the Western medicine. Meanwhile, the drugs are suitable for health use of patients with mild hypertension or normal hypertension.

Description

Technical field [0001] The invention relates to a medicine preparation technology, and particularly relates to a method and application for preparing a medicine for treating hypertension by using Dendrobium officinale and Scutellaria as the main materials. Background technique [0002] Hypertension is a common clinical disease with high incidence, which has serious harm to important organs such as heart, brain and kidney. my country’s 2013 China Cardiovascular Disease Report estimates that there are currently approximately 270 million hypertensive patients nationwide. The 2012 and 2013 "China Cardiovascular Disease Report" showed that my country's cardiovascular disease fatality rate was 44.1%, ranking first in the spectrum of death diseases. Hypertension is the primary cause of cardiovascular and cerebrovascular diseases. Epidemiological survey results show that the mortality rate of cardiovascular and cerebrovascular diseases in my country due to hypertension is increasing ye...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P9/12
CPCA61K36/31A61K36/65A61K36/71A61K36/8968A61K36/8984A61K2236/331A61K2236/333A61K2236/53A61K2300/00
Inventor 吴人照
Owner HANGZHOU DANHE PHARM CO LTD
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