Novel compound anticoccidial soluble powder and preparation method thereof
A soluble and anti-coccidial technology, used in anti-infective drugs, powder delivery, pharmaceutical formulations, etc., can solve the problems of poor market feedback, restrict the use of premixes, and reduce therapeutic effects, and achieve stable and lasting drug efficacy. The effect of drug dissolution and increasing drug stability
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Embodiment 1
[0022] A compound sulfachlorpyrazine sodium trimethoprim soluble powder, its raw material components (by weight) are as follows:
[0023] 21 parts of sulfachlorpyrazine sodium raw material, 4 parts of trimethoprim raw material, active excipient: 2 parts of disodium edetate, solid dispersion carrier: 30 parts of water-soluble modified caraya gum (MGK) , Anticaking agent: 4 parts of sodium hexametaphosphate, filler: lactose and anhydrous glucose (1:1) added to 100 parts. Take above-mentioned raw material component and prepare compound sulfachlorpyrazine sodium trimethoprim soluble powder according to the following steps:
[0024] 1. Carry out a solid-solid phase melting reaction between the trimethoprim (TMP) raw material and the solid dispersion carrier, heat at 80°C for 120 minutes, wait until it is completely dissolved, then add active excipients, mix well, cool to room temperature, and pulverize Afterwards, all passed through 100 meshes to obtain TMP-SD solid dispersion A; ...
Embodiment 2
[0028] A compound sulfachlorpyrazine sodium trimethoprim soluble powder, its raw material components (by weight) are as follows:
[0029] 21 parts of sulfachlorpyrazine sodium raw material, 4 parts of trimethoprim raw material, active excipient: 3 parts of sodium lauryl sulfate, solid dispersion carrier: 20 parts of polyethylene glycol 6000, anticaking agent: anhydrous Magnesium sulfate 4 parts, filler: xuanming powder and anhydrous glucose (1:1) added to 100 parts. Take above-mentioned raw material component and prepare compound sulfachlorpyrazine sodium trimethoprim soluble powder according to the following steps:
[0030] 1. Carry out a solid-solid phase melting reaction between the trimethoprim (TMP) raw material and the solid dispersion carrier, heat at 80°C for 120 minutes, wait until it is completely dissolved, then add active excipients, mix well, cool to room temperature, and pulverize Afterwards, all passed through 100 meshes to obtain TMP-SD solid dispersion A;
...
Embodiment 3
[0034] A compound sulfachlorpyrazine sodium trimethoprim soluble powder, its raw material components (by weight) are as follows:
[0035] 21 parts of sulfachlorpyrazine sodium raw material, 4 parts of trimethoprim raw material, active excipient: 5 parts of sodium dodecylbenzenesulfonate, solid dispersion carrier: Poloxamer 188 25 parts, anticaking agent: Anhydrous magnesium sulfate (2 parts), sodium hexametaphosphate 2 parts, filler: xuanming powder and anhydrous glucose (1:1) were added to 100 parts. Take above-mentioned raw material component and prepare compound sulfachlorpyrazine sodium trimethoprim soluble powder according to the following steps:
[0036] 1. Carry out a solid-solid phase melting reaction between the trimethoprim (TMP) raw material and the solid dispersion carrier, heat at 80°C for 120 minutes, wait until it is completely dissolved, then add active excipients, mix well, cool to room temperature, and pulverize Afterwards, all passed through 100 meshes to o...
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