55results about How to "Promote bone regeneration" patented technology

A fixing member for an implant which comprises a tube or a pillar made of an hydroxyapatite ceramics at least one part of which is a ceramics porous article consisting essentially of a hydroxyapatite formed by agitation foaming, in which a number of approximately spherical pores mutually contact having pore structures communicated three-dimensionally opened at the contact area and having an averaged porosity of from 65% to 85%. A method for fixing an implant comprising a step of inserting an implant whose at least one part of the periphery is integrated with a hydroxyapatite ceramics into an implant insertion site of an alveolar bone or a gnathic bone. A method for fixing an implant, a fixing member for the implant and an implant composite in order to reinforce an implant insertion site by compensating or regenerating an alveolar bone or a gnathic bone on an implant treatment in dentistry or in oral surgery is obtained.

The present invention incorporates new materials for bone regeneration, methods for their manufacture, and application in traumatology surgery, maxillo facial surgery, dental surgery, orthognatic surgery, endodontics, ophthalmology, neurosurgery and / or osteoporotic processes, and other indications where bone regeneration is required. In particular, the present invention incorporates synthetic materials with a 20% to a 95%, preferably between 40% and 90% in mass of monetite [Ca1-XMXHPO4, where 0≦x≦0.05, and where M can be a divalent metallic ion], and which in their final composition incorporate between 5% and 80%, preferably between 0% and 60%, in mass of bioactive calcium compounds chosen from calcium phosphates and between 5% and 80% in total mass of bioactive silicon compounds chosen from calcium silicates and / or bioactive silica glasses and gels.

The present invention incorporates new materials for bone regeneration, methods for their manufacture, and application in traumatology surgery, maxillofacial surgery, dental surgery, orthognatic surgery, endodontics, ophthalmology, neurosurgery and / or osteoporotic processes, and other indications where bone regeneration is required. In particular, the present invention incorporates synthetic materials with a 20% to a 95%, preferably between 40% and 90% in mass of monetite [Ca1-XMXHPO4, where 0≦x≦0.05, and where M can be a divalent metallic ion], and which in their final composition incorporate between 5% and 80%, preferably between 0% and 60%, in mass of bioactive calcium compounds chosen from calcium phosphates and between 5% and 80% in total mass of bioactive silicon compounds chosen from calcium silicates and / or bioactive silica glasses and gels.

A composite intended for medical use, in particular surgical or therapeutic use, characterized in that it comprises a mixture ofa thermoplastic component plasticizable within the temperature range -10° . . . +100° C., which is substantially made up of hydroxy acids and structural units derived from hydroxy acid derivatives and the molar mass of which is within the range 30,000-1,000,000 g / mol, and which degrades in the body typically within a period ranging from a few days to several years, and which in its solid state is a mechanically strong plastic or rubbery material, anda bioactive component, which is a bioactive glass or a bioactive xerogel,such that the plasticized thermoplastic component remains moldable for a certain period even after the temperature of the composite has been lowered to a temperature which is considerably lower than the setting temperature of said thermoplastic component.

It is an object of the present invention to provide a method for effectively regenerating bone, and more specifically to provide a method for regenerating bone that is capable of treating patients suffering from bone defect or bone injury. The present invention provides a method for regenerating bone, which comprises culturing and / or transplanting mesenchymal cells in the coexistence of epithelial cells.

A sleeve-type superfine diameter osteofixation needle comprises a power assisting sleeve and a superfine diameter osteofixation needle disposed in the power assisting sleeve, one end of the power assisting sleeve being provided with an adapter seat to connect to a rotor of a drive electric motor, and another end is provided with a detachable rigid connection apparatus. The power assisting sleeve is fixed to the osteofixation needle by means of the rigid connection apparatus, and the rigid connection apparatus limiting extension of a needle tip of the osteofixation needle from the power assisting sleeve to a set length. Starting the electric motor can cause the electrically driven osteofixation needle to enter a bone by means of percutaneous self-tapping drilling, and after the needle tip of the osteofixation needle extending from the power assistance sleeve penetrates a target bone, detaching the rigid connection apparatus from a distal end of the power assistance sleeve, removing thepower assistance sleeve from the osteofixation needle; finally, screwing into an anchor bone matrix by means of needle-holding forceps gripping a screw thread section of a back part of the osteofixation needle. Feasibility of percutaneous anchor needle puncturing is realized for small animal bone fracture and bone malformation models and clinical osteofixation of small bone breaks in specific parts, including hand and foot; the method is simple and convenient, time-saving and efficient, causes little surgical trauma, and needle anchoring stability is reliable.

The use of Herapan Sulphate 2 (HS-2) in therapeutic bone growth and regeneration is described. Herapan Sulphate 2 was identified as a variant of Heparan Sulphate purified from embryonic day (E10) of murine neuroepithelia.

The invention discloses a formula of a 3D-printing artificial bone composite fiber protein scaffold and a preparation method of same, the scaffold includes five components: medical-grade collagen powder, a 0.05 mol / L acetic acid solution, medical-grade hydroxylapatite powder, a 1 mass% genipin solution, and platelet-rich fibrin. The preparation method includes the steps of: 1) dissolving the medical-grade collagen powder in the 0.05 mol / L acetic acid solution to obtain collagen colloid; 2) uniformly stirring the medical-grade hydroxylapatite powder and collagen colloid to prepare a hydroxylapatite / collagen printing raw material, and according to bone defect CT data of a patient, printing a hollow individual tissue-engineered bone by means of a 3D bio-printing machine; 3) during an operation process of transplanting the artificial bone scaffold, centrifuging blood of the patient to prepare the platelet-rich fibrin, and injecting the platelet-rich fibrin into the tubular cavity in the tissue-engineered bone to obtain the artificial bone which contains the hydroxylapatite, collagen and platelet-rich fibrin and has capability of improving osteanagenesis of human body. The artificial bone can slowly release the autologous growth factor in the platelet-rich fibrin of the patient, thus improving recovery of the osteanagenesis of human body.

Provided is a fracture treatment device enabling efficient bone regeneration. The fracture treatment device (10) for connecting a bone on one side of a fracture site and a bone on the other side of the fracture site, the device including a fixation member (11) having a stick shape, a tissue regeneration structure (15) disposed in a manner to cover at least a part of the fixation member, wherein the tissue regeneration structure includes a support body made of a bioabsorbable material and cells retained in the support body, which cells regenerate bone.

The present invention relates to a method for inducing and / or promoting osteogenic differentiation using extracellular vesicles and the use thereof.

The invention is directed to a method for adapting a bone graft implantable into a host bone for promoting host bone regeneration, the method comprising providing a bone graft comprising bone material and having a surface contactable with a host bone; and adapting at least a portion of the surface to produce a surface roughness similar to the roughness of a fracture surface of bone. Also included is a bone graft having at least a portion of a bone graft surface with a surface roughness similar to that of a fracture surface of bone, a device for adapting bone material having a plurality of impact tips to contact a surface of the bone material to be adapted to produce a bone material surface roughness similar to the roughness of a fracture surface of bone, and use of a device to adapt a surface of a bone material, the device having an impact tip arranged to contact the surface of the bone material to adapt the surface to produce a surface roughness similar to the roughness of a fracture surface of bone.

The invention discloses a silk fibroin-dopamine-E7 oligopeptide compound stent which comprises a silk fibroin porous stent. E7 oligopeptide is grafted to the silk fibroin porous stent through dopamine. The silk fibroin porous stent is prepared by electrospinning. The silk fibroin porous stent is impregnated in a dopamine solution and an E7 oligopeptide solution successively to obtain the stent. The compound stent not only improves the hydrophilicity and promotes cell adhesion and proliferation, but also accelerates osteogenic differentiation of BMSCs by means of joint action of dopamine and E7, and the stent has very high raising efficiency to BMSCs in vitro and in vivo, so that osteanagenesis is promoted.

The invention discloses a porous metal bone implant material and its preparation method and application and belongs to the technical field of biomedical materials. The porous metal bone implant material comprises a porous metal material matrix and a silk fibroin material filling the pores of the porous metal material matrix. The porous metal material matrix is prepared from metal raw material powder through 3D printing. The silk fibroin material is loaded with a bioactive drug. The preparation method comprises 1) preparing a customized 3D printed porous metal material matrix according to demands, 2) preparing a silk fibroin solution and loading the silk fibroin with a bioactive drug, and 3) filling pores of the porous metal material matrix with the silk fibroin with the bioactive drug, and carrying out freeze-drying to obtain the porous metal bone implant material. The porous metal bone implant material is precisely controlled in structure, can be customized, can effectively improve osseointegration of a metal bone implant in diabetic patients and can reduce the loosening rate of the implant.

The invention relates to a completely degradable bone repairing material and a preparation method thereof, and belongs to the field of biomaterials. The repairing material takes degradable aliphatic polyester with biocompatibility and a natural degradable polymer as main raw materials, a black phosphorus nanometer multi-sheet layer capable of being completely biodegradable and accelerating bone formation is added, and an electrostatic spinning, solution pouring or 3D printing method is adopted to prepare the bone repairing material. The bone repairing material disclosed by the invention exhibits excellent complete degradability, bone defect repairing can be accelerated, a secondary operation is not required, and a problem that the bone repairing material is insufficient and incomplete in degradation in a body can be solved.

Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited in by short in vivo half-lives and a narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. A nanoscale controlled release system (degradable protein nanocapsule) is provided via in-situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes are achieved with the growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 (BMP-2) nanocapsules.

A composition having Lactobacillus Plantarum strain GMNL-662 for promoting bone regrowth is provided. The Lactobacillus Plantarum strain GMNL-662 has an ability to promote the expression of osteogenic genes, inhibit the expression of osteoclast related genes, and promote the expression of osteogenesis-related cytokine TGF-β, so that the bone loss is improved.

The invention provides a degradable temperature-sensitive adhesive, a preparation method and application thereof. The degradable temperature-sensitive adhesive is obtained by mixing a water-soluble prepolymer and a Fe<3+> solution, and the water-soluble prepolymer is prepared from the following raw materials: polybasic acid and / or polybasic acid salt; PEG-PPG-PEG; an alcohol, amine or acid containing a catechol group or a gallic acid group; and a metal carbonate and / or metal bicarbonate or tertiary amine. The preparation method comprises the following steps of: adding metal carbonate and / or metal bicarbonate into a non-water-soluble prepolymer, carrying out reversible crosslinking on metal ions and carboxyl in the non-water-soluble prepolymer to successfully prepare a water-soluble prepolymer soluble in water, and curing the obtained adhesive at a temperature of about 37DEG C to obtain a uniformly crosslinked adhesive. When the temperature is changed, the adhesive can be converted intoa liquid state, has thermosensitivity, can be used for wound closure or bone defect repair, and can be used as a local drug release carrier.

The invention discloses preparation of hydrogel microspheres for repairing bone defects and an application thereof, and belongs to the technical field of biological medicines. According to the preparation method, the hydrogel microspheres with different diameters and different proportions can be prepared by using a microfluidic device and taking methylacryloylated gelatin and nano-hydroxyapatite as raw materials through an ultraviolet crosslinking principle, and the hydrogel microspheres prepared by the preparation method have good mechanical stability, biocompatibility and osteogenesis regeneration capacity; the preparation method of the microspheres is simple, can be used for batch production, and has a good application prospect.

An anchoring implant to be screwed into a hole and self-lock therein with secure stability. The implant, which may be used in dental, orthopedic or any of several non-medical applications, has a conically tapered profile with an aggressively-threaded, self-tapping apical end. A central region of the implant is formed with a plurality of burnishing edges each configured to apply a circumferentially sweeping compressive strain to the interior surface of the hole with a burnishing action while the implant is being screwed into position. A coronal end of the implant includes a corking feature to avert mushrooming around the perimeter of the hole. A central thread profile may extend through and intersect the burnishing edges to provide either enhanced self-tapping or enhanced corking functionality. The extreme coronal end comprises a platform for receiving an abutment or other fastening element via an internal connect feature.

The invention discloses a tissue engineering scaffold assembled by cell-loaded microgel as well as a preparation method and application thereof, and belongs to the technical field of biomedical engineering. Firstly, gel microspheres carrying bioactive substances prepared from a biological material with good biocompatibility by adopting a micro-flow liquid drop control technology are used to serve as basic units, and the cell-loaded gel microspheres are assembled into the tissue engineering scaffold by adopting a biological 3D printing mode. The micro-flow liquid drop control technology adopted by the invention can effectively shorten the preparation time of the cell-loaded gel microspheres, improve the preparation efficiency and ensure the cell activity; and the construction of a three-dimensional complex structure can be realized by utilizing a biological printing mode, and the application prospect is good.

Provided are a porous composite containing OCP and collagen having higher compressive strength than before: a bone regeneration material containing the same: and a method for producing a porous composite. The porous composite contains octacalcium phosphate and collagen, has a pore size of 5 to 40 μm as determined by measurement using a mercury porosimeter, and contains pores of 71 to 200 μm at a rate of less than or equal to 8% in all pores of less than or equal to 200 μm.

The use of Herapan Sulphate 2 (HS-2) in therapeutic bone growth and regeneration is described. Herapan Sulphate 2 was identified as a variant of Heparan Sulphate purified from embryonic day (E10) of murine neuroepithelia.

The invention belongs to the technical field of medicine, and particularly relates to a medical titanium implant, a preparation method of the medical titanium implant and application of the medical titanium implant. The preparation method of the medical titanium implant comprises the following steps: producing a pretreated titanium matrix; dispersing the titanium matrix in a dopamine solution for polymerization reaction to obtain a composite titanium matrix of which the surface is combined with a polydopamine layer; and preparing a precursor solution containing a polylactic acid-glycolic acid copolymer and melatonin, and spinning the precursor solution on the surface of the composite titanium substrate to obtain the medical titanium implant. The medical titanium implant prepared by the invention has antioxidant activity, can promote the formation of new bones, and also has a proper in-vivo degradation rate, so that melatonin has a continuous and long-acting drug slow release rate, and therefore, the medical titanium implant plays a long-acting role in promoting the formation of the bones.

The invention provides an osteoporosis diagnostic marker and a nucleic acid medicine for promoting osteoporosis bone regeneration. The osteoporosis diagnosis marker is Piwi protein binding RNA-63049, and has a nucleotide sequence as shown in SEQ ID NO. 1. The nucleic acid medicine for promoting osteoporotic bone regeneration is an antagonist of Piwi protein binding RNA-63049. After the piwi protein is combined with piRNA-63049, a piR-63049 / piwi protein complex is formed, so that the expression of the Wnt2b protein is inhibited, and further, the osteogenic differentiation capability of the BMSCs is weakened; and the piRNA-63049 antagonist plays roles in promoting bone regeneration and preventing osteoporosis bone mass loss in vivo, so that the piRNA-63049 antagonist can be used as a nucleic acid medicine for promoting osteoporosis bone regeneration.

Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and / or regeneration of connective tissue and bones, and the treatment of wounds.

The present invention relates to a bio-adhesive agent comprising a surface-modified hydroxyapatite and its use. More specifically, the present invention relates to a bio-adhesive agent for the adhesion between bone and bone, bone and tissue, bone and cartilage, or bone and tendon, or for the adhesion of a shield between bones or of an artificial joint, which comprises a surface-modified hydroxyapatite as an active ingredient, wherein the surface-modified hydroxyapatite is characterized in that a certain linker compound is covalently bonded to the surface of the hydroxyapatite; a method for coating the surface of a metal prosthesis using the surface-modified hydroxyapatite; and a metal prosthesis coated with the surface-modified hydroxyapatite obtained by said method.

The present invention provides methods and compositions for promoting bone regeneration, comprising administration of calmodulin. The method of bone regeneration is applied to subjects having bone disorders characterized by decreased bone mass such as osteopenia and osteoporosis, as well as those suffering from non-union fractures.