55results about How to "Promote bone regeneration" patented technology

A sleeve-type superfine diameter osteofixation needle comprises a power assisting sleeve and a superfine diameter osteofixation needle disposed in the power assisting sleeve, one end of the power assisting sleeve being provided with an adapter seat to connect to a rotor of a drive electric motor, and another end is provided with a detachable rigid connection apparatus. The power assisting sleeve is fixed to the osteofixation needle by means of the rigid connection apparatus, and the rigid connection apparatus limiting extension of a needle tip of the osteofixation needle from the power assisting sleeve to a set length. Starting the electric motor can cause the electrically driven osteofixation needle to enter a bone by means of percutaneous self-tapping drilling, and after the needle tip of the osteofixation needle extending from the power assistance sleeve penetrates a target bone, detaching the rigid connection apparatus from a distal end of the power assistance sleeve, removing thepower assistance sleeve from the osteofixation needle; finally, screwing into an anchor bone matrix by means of needle-holding forceps gripping a screw thread section of a back part of the osteofixation needle. Feasibility of percutaneous anchor needle puncturing is realized for small animal bone fracture and bone malformation models and clinical osteofixation of small bone breaks in specific parts, including hand and foot; the method is simple and convenient, time-saving and efficient, causes little surgical trauma, and needle anchoring stability is reliable.

The invention discloses a formula of a 3D-printing artificial bone composite fiber protein scaffold and a preparation method of same, the scaffold includes five components: medical-grade collagen powder, a 0.05 mol / L acetic acid solution, medical-grade hydroxylapatite powder, a 1 mass% genipin solution, and platelet-rich fibrin. The preparation method includes the steps of: 1) dissolving the medical-grade collagen powder in the 0.05 mol / L acetic acid solution to obtain collagen colloid; 2) uniformly stirring the medical-grade hydroxylapatite powder and collagen colloid to prepare a hydroxylapatite / collagen printing raw material, and according to bone defect CT data of a patient, printing a hollow individual tissue-engineered bone by means of a 3D bio-printing machine; 3) during an operation process of transplanting the artificial bone scaffold, centrifuging blood of the patient to prepare the platelet-rich fibrin, and injecting the platelet-rich fibrin into the tubular cavity in the tissue-engineered bone to obtain the artificial bone which contains the hydroxylapatite, collagen and platelet-rich fibrin and has capability of improving osteanagenesis of human body. The artificial bone can slowly release the autologous growth factor in the platelet-rich fibrin of the patient, thus improving recovery of the osteanagenesis of human body.

The invention is directed to a method for adapting a bone graft implantable into a host bone for promoting host bone regeneration, the method comprising providing a bone graft comprising bone material and having a surface contactable with a host bone; and adapting at least a portion of the surface to produce a surface roughness similar to the roughness of a fracture surface of bone. Also included is a bone graft having at least a portion of a bone graft surface with a surface roughness similar to that of a fracture surface of bone, a device for adapting bone material having a plurality of impact tips to contact a surface of the bone material to be adapted to produce a bone material surface roughness similar to the roughness of a fracture surface of bone, and use of a device to adapt a surface of a bone material, the device having an impact tip arranged to contact the surface of the bone material to adapt the surface to produce a surface roughness similar to the roughness of a fracture surface of bone.

The invention discloses a porous metal bone implant material and its preparation method and application and belongs to the technical field of biomedical materials. The porous metal bone implant material comprises a porous metal material matrix and a silk fibroin material filling the pores of the porous metal material matrix. The porous metal material matrix is prepared from metal raw material powder through 3D printing. The silk fibroin material is loaded with a bioactive drug. The preparation method comprises 1) preparing a customized 3D printed porous metal material matrix according to demands, 2) preparing a silk fibroin solution and loading the silk fibroin with a bioactive drug, and 3) filling pores of the porous metal material matrix with the silk fibroin with the bioactive drug, and carrying out freeze-drying to obtain the porous metal bone implant material. The porous metal bone implant material is precisely controlled in structure, can be customized, can effectively improve osseointegration of a metal bone implant in diabetic patients and can reduce the loosening rate of the implant.

The invention relates to a completely degradable bone repairing material and a preparation method thereof, and belongs to the field of biomaterials. The repairing material takes degradable aliphatic polyester with biocompatibility and a natural degradable polymer as main raw materials, a black phosphorus nanometer multi-sheet layer capable of being completely biodegradable and accelerating bone formation is added, and an electrostatic spinning, solution pouring or 3D printing method is adopted to prepare the bone repairing material. The bone repairing material disclosed by the invention exhibits excellent complete degradability, bone defect repairing can be accelerated, a secondary operation is not required, and a problem that the bone repairing material is insufficient and incomplete in degradation in a body can be solved.

A composition having Lactobacillus Plantarum strain GMNL-662 for promoting bone regrowth is provided. The Lactobacillus Plantarum strain GMNL-662 has an ability to promote the expression of osteogenic genes, inhibit the expression of osteoclast related genes, and promote the expression of osteogenesis-related cytokine TGF-β, so that the bone loss is improved.

The present invention provides methods and compositions for promoting bone regeneration, comprising administration of calmodulin. The method of bone regeneration is applied to subjects having bone disorders characterized by decreased bone mass such as osteopenia and osteoporosis, as well as those suffering from non-union fractures.