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Medical titanium implant, preparation method thereof and application of medical titanium implant

An implant, titanium matrix technology, applied in the medical field, can solve the problems of high loosening rate, difficult to carry drugs, poor osteogenesis on the surface of titanium implants, etc. The effect of sustained release rate of potent drug

Inactive Publication Date: 2021-11-16
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of this application is to provide a medical titanium implant and its preparation method, as well as the application of the medical titanium implant, aiming to solve the problem of high loosening rate of bone implants in diabetes environment and bone formation on the surface of titanium implants to a certain extent. Problems with poor conditions and difficult to carry medications

Method used

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  • Medical titanium implant, preparation method thereof and application of medical titanium implant
  • Medical titanium implant, preparation method thereof and application of medical titanium implant
  • Medical titanium implant, preparation method thereof and application of medical titanium implant

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preparation example Construction

[0044] The first aspect of the embodiment of the present application provides a method for preparing a medical titanium implant, comprising the following steps:

[0045] S10. Obtain the pretreated titanium substrate;

[0046] S20. Dispersing the titanium matrix in a dopamine solution to carry out a polymerization reaction to obtain a composite titanium matrix with a polydopamine layer bound to the surface;

[0047] S30. Prepare a precursor solution containing polylactic acid-glycolic acid copolymer and melatonin, and spin the precursor solution on the surface of the composite titanium matrix to obtain a medical titanium implant.

[0048] In the preparation method of the medical titanium implant provided in the first aspect of the embodiment of the present application, firstly, the titanium matrix is ​​dispersed in the dopamine solution by soaking, etc., and a layer of polydopamine is modified on the surface of the titanium matrix, which not only improves the biological phase o...

Embodiment 1

[0071] A kind of medical titanium implant, its preparation comprises the steps:

[0072] ① Surface pretreatment of pure titanium substrate: ultrasonically clean the polished titanium sheet twice, 20 minutes each time.

[0073] ②Polydopamine surface modification: Soak the polished and cleaned titanium sheet in a dopamine solution (2mg / ml) prepared with Tris-HCl buffer solution (10mmol, pH=8.5), take it out after 24 hours of reaction, and use deionized water to sonicate Wash 3 times, 10 minutes each time, and then vacuum dry at 27° C. for 24 hours to prepare a titanium sheet (PDA-Ti) with a polydopamine film on the surface.

[0074] ③ Electrospun PLGA nanofiber film modification: Dissolve PLGA with TCM / DMF (7 / 3, v / v) mixed solvent, the concentration is 16% (m / v), then add a certain amount of melatonin respectively, the configuration concentration is 5% melatonin to obtain a melatonin-PLGA solution and stirred for two hours to obtain a precursor solution. Put the precursor liqu...

Embodiment 2

[0076] A medical titanium implant, the difference from Example 1 is that the concentration of melatonin in step ③ is 10%, and 10% PLGA@MT is obtained.

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a medical titanium implant, a preparation method of the medical titanium implant and application of the medical titanium implant. The preparation method of the medical titanium implant comprises the following steps: producing a pretreated titanium matrix; dispersing the titanium matrix in a dopamine solution for polymerization reaction to obtain a composite titanium matrix of which the surface is combined with a polydopamine layer; and preparing a precursor solution containing a polylactic acid-glycolic acid copolymer and melatonin, and spinning the precursor solution on the surface of the composite titanium substrate to obtain the medical titanium implant. The medical titanium implant prepared by the invention has antioxidant activity, can promote the formation of new bones, and also has a proper in-vivo degradation rate, so that melatonin has a continuous and long-acting drug slow release rate, and therefore, the medical titanium implant plays a long-acting role in promoting the formation of the bones.

Description

technical field [0001] The application belongs to the field of medical technology, and in particular relates to a medical titanium implant, a preparation method thereof, and an application of the medical titanium implant. Background technique [0002] Titanium alloys have good formability and mechanical properties, and have broad application prospects in orthopedic implants. The stability of titanium implants depends on the orderly structural and functional connection between human bone tissue and the implant surface, that is, the osseointegration of the "titanium-bone" interface, which is essentially the new repair of bone tissue at the interface and the formation of new bone. The process of attaching directly to the surface of the implant. Modifying the surface of titanium alloy implants to increase its specific surface area, improve biocompatibility, and even carry specific drugs to induce the differentiation of mesenchymal stem cells into osteoblasts is an important asp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/34A61L27/56A61L27/50A61L27/54A61L27/28
CPCA61L27/06A61L27/34A61L27/56A61L27/50A61L27/54A61L27/28A61L2430/02A61L2400/12A61L2300/602A61L2300/412A61L2300/216C08L79/04C08L67/04
Inventor 王子杰王林吴紫媚蒋星竹侯峤丹王蕾江恒锋吴云潇潇
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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