86 results about "Osteoporotic bone" patented technology

A Novel surgical apparatus and method of use in osteoplasty and other methods of injecting materials into a subject for medical purposes. The present invention particularly relates to the surgical treatment of traumatic, pathogenic, or osteoporotic bone conditions of the human and other animal body systems and more particularly, to a novel apparatus and method for injection of a material into a lesion of a vertebral body or other bony structure.

A mechanical bone tamping device for osteoporotic repair include a pair of arms mounted on a spreading mechanism such as a screw jack. The mechanism is introduced into a small hole in a vertebra through a cannula, and is then operated to spread the arms apart, forming a cavity which may be filled with cement to fortify the vertebra.

Controlling the transformation of the microstructure of shape memory material implants. A surgeon can use the inventive energy delivery device to control the rate of implant shape change, the extent of implant shape change, as well as the force exerted on the surrounding tissue. The invention allows for the fine control of force when fixating osteoporotic bone and rate of bone transport. This system models or measures the heating profile of the implant and provides the surgeon a method to control the extent of microstructure phase transformation so that the rate, force or extent of tissue movement can be controlled individually or together.

The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable. A method for treating a bone defect also is provided by identifying a bone site suitable for receiving an implant, and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporotic bone, an intervertebral space, an alveolar ridge or a bone fracture.

A device includes an elongated body configured to be coupled to a bone stabilization implant so that, when the bone stabilization implant is mounted to a target bone, the body extends away from the bone stabilization implant at an angle selected so that the elongated body passes into a target portion of bone. The body defines a lumen therein extending to an opening in a distal end of the body. The device also includes a deploying member housed within the lumen of body for movement between a first position and a second position. In addition, the device includes a plurality of wires coupled to the deploying member so that movement of the deploying member through the lumen moves the wires between an insertion position and a deployed position in which the distal ends of the wires penetrate a portion of bone adjacent to the distal end of the body.

The invention relates to a medicine compound for treating osteoporosis and osteoporosis fracture, which comprises the following components by weight: 30 g of rhizoma drynariae, 25 g of radices dipsaci, 15 g of radices polygoni multiflori, 22 g of turtleback, 20 g of herba epimedii, 9 g of woodlouse, 10 g of native copper, 20 g of red sage root, 15 g of safflower, 12 g of radices paeoniae alba, 9 g of radix clematidis, 10 g of fructus cnidii, 12 g of lignum millettiae, 30 g of angelica, 20 g of astragalus root, 22 g of Chinese yam, 12 g of tuckahoe, 20 g of prepared rhizome of rehmannia, 15 g of antler glue, 15 g of rhizoma cibotii, 12 g of achyranthes, 10 g of cortex eucommiae, 9 g of ossa draconis, 15 g of fructus ligustri lucidi, 10 g of fructus psoraleae, 12 g of atractylodes ovata, 12 g of semen melo, 15 g of elder, 15 g of medlar, 10 g of rhizoma homalonemae, 25 g of cuttle-bone, 8 g of frankincense, and 8 g of myrrh. The medicine compound is suitable for osteoporosis, low in cost, and remarkable in treatment effect, and has a board application prospect.

Methods and articles of manufacture for treating patients with degenerative bone are provided. The methods are useful to improve bone quality in a localized area of a degenerative bone (e.g., osteopenic or osteoporotic bone), such as by improving BMD to be substantially similar to BMD in an average, healthy individual at the age of peak BMD. The methods can comprise forming a void in a localized area of the degenerative bone and filling the void with a bone regenerative material that causes generation of new, healthy, natural bone material. The articles of manufacture can comprise kits formed of various materials useful in the inventive methods for improving bone quality.

Embodiments of present invention include modular bone plate systems and various methods of bone fixation using the same. The system makes available to the practitioner an array of plates, screws and pins with different sizes, curves, and functions to overcome complication of the procedure with minimal rework and soft / hard tissue intervention, treat osteoporotic bones and articular fracture to name a few.

Compositions are provided which stimulate bone growth. Also provided are methods for utilizing the compositions for filling in bone defects, promoting rapid fusion of bone fractures, grafts, and bone-prostheses, and promoting strengthening of osteoporotic bones.

The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat osteoporotic bone, in that such depot implant is constructed to be in a cylinder (rod) or sphere shape and have a natural or synthetic polymer scaffold with or without impregnated calcium phosphate particles. The density of the depot is higher than a typical BMP sponge carrier to facilitate it's implantation and slower release of the growth factor. The scaffold is such that it has adequate porosity and pore size to facilitate growth factor seeding and diffusion throughout the whole of the bone structure resulting in increased bone mineral density in the osteoporotic bone. In addition, the shape of the depot implant allows for delivery through a cannula or large bore needle.

A compression wire is partially threaded and has a trocar insertion point for insertion into a bone segment to be stabilized with respect to a second bone segment. A button mates with the wire and is crimped into position on the wire to cause compression and stabilization between the bone segments. A cannulated instrument is used to grasp and apply tension to the wire at a given torque, and further to crimp the button to maintain tension on the wire in a location suitable for later removal. In a second embodiment for osteoporotic bone the wire further includes an internally threaded screw or helix which is implanted into the bone segment to mate with the threads of the wire. The invention further relates to the method of bone stabilization where the threaded wire is implanted into the distil end of a bone segment in ante grade or retro grade and also in a sub-cutaneous or percutaneous fashion and extending through an adjacent bone segment. An end of the wire protrudes from the second bone segment and end receives a button slid onto the wire and crimped into the desired tension. The end of the wire assembly may be left proud for later removal, or countersunk in the bone so as not to protrude.

The invention relates to a device for fixing screws in osteoporotic bones, formed by biocompatible fixing elements and an instrument for placing same. The instrument consists of two parts, a male part (A) and a female part (B), which can perform a relative linear sliding movement. The caudal end of each part has a pivoting jaw (Pa, Pb) forming an inverted U therebetween. The biocompatible element is placed in the jaw of the male part, which element will be traversed by a screw inserted through interchangeable guides (g) placed in the other jaw, acting as a locking and fixing nut for said screw. Both parts have a handle (m) to allow moving the jaws closer together. The opening of the device, restricted by a closure (C), is achieved by the action of a compression spring (R), upon releasing, by the action of the thumb, the catch inserted in the upper face, cut in a saw-toothed manner, of part A.

The invention discloses a big-data-based bone quality assessment expert system and a prediction model establishment method. The system is composed of a server, in which a prediction model module, a data acquisition module and a bone expert module are arranged. A database and an intelligent terminal are connected on the server. The database stores user identity data, characteristic data of historical patients with osteoporosis and fractures, and detection data of to-be-predicted patients. The prediction model module establishes an osteoporosis fracture prediction model; and the data acquisitionmodule is used for acquiring prediction requests and detection data of to-be-predicted patients. The osteoporosis fracture prediction model obtains an osteoporosis fracture prediction level based onthe detection data; and the bone expert module outputs prevention advice to each to-be-predicted patient. The big-data-based bone quality assessment expert system has the following beneficial effects:the fracture prediction of the osteoporosis patient is realized; the operation is convenient without queuing up; the system can be operated at any time at any place; and intelligent and convenient effects are realized.

The present invention provides methods for prevention, prevention of progression, and treatment of osteoporosis and pre-osteoporotic conditions comprising direct administering to osteoporetic bone of a composition comprising amphiphilic peptides and peptide matrices thereof, useful in promoting biomineralization, local osteoporetic medications and inducing bone repair.

The present invention provides methods for treating physical conditions resulting from postmenopausal estrogen decline in a postmenopausal subject, and in particular methods for reducing the risk of osteoporotic bone fractures in a postmenopausal subject. The present invention also provides a kit useful for carrying out the methods of the present invention.

A method of increasing a pullout force of a threaded fastener in osteoporotic bone includes drilling a hole in the bone. The spacer fabric is impregnated with a bone growth agent. A tube of the spacer fabric is sized to the hole in the bone. The tube of the spacer fabric is inserted in the hole of the bone. The spacer fabric is made from Nitinol wire. A threaded fastener is inserted into a central lumen of the tube of the spacer fabric to provide a rigid structure. The bone is grown into the spacer fabric.

The invention relates to a bone screw for fixing an osteoporosis bone. The bone screw comprises a bone screw body; the internal part of the bone screw is provided with a first axial channel and a second axial channel; a first radial hole communicated with the first channel and a second radial hole communicated with the second channel are formed in the surface of the bone screw body. According to the bone screw provided by the invention, as the two internal channels are arranged, the bone screw can finish bone cement filling by utilizing one of the channels in the osteoporosis fracture bone, and the other channel can be utilized to perform relevant drug or nutrient substance conveying, so that the complication diseases after the bone cement is solidified can be dealt with and the health and nutrition conditions of surrounding osteoporosis bones can be improved.

The invention discloses a new application of statin compound as topical medicine for preventing and curing osteoporotic fracture and enhancing bone plant strength in osteoporotic bone, particularly, discloses a topical statin composite for bone. The topical statin composite can increase bone mass, improve bone density, improve bone tissue microstructure and enhance bone mechanical property, thereby being used for preventing and curing osteoporotic fracture and enhancing the bone plant strength in osteoporotic bone.

The invention relates to 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7B(PDE7B). Diseases and conditions mediated by PDE7B include osteoporosis, osteopenia and asthma.

The subject matter of the invention is a curable composition for use as bone cement, in particular for augmentation of osteoporotic bone tissue, comprising at least one organic polymer and at least one monomer for radical polymerisation, at least one particulate inorganic additive having a BET surface of at least 40 m2 / g, whereby the additive comprises covalently bound hydroxyl groups, whereby the composition further comprises at least one fatty acid ester or a mixture of fatty acid esters. Another subject matter of the invention is the use of said composition for augmentation of osteoporotic bone tissue and particularly preferably for vertebroplasty, kyphoplasty, and augmentation of drill holes in osteoporotic bone tissue, as well as a kit for producing said composition.

The present invention relates to a preparation method and an application of a GelMA hydrogel for locally slow-releasing Abaloparatide or related polypeptides. Gel methacrylate anhydride monomers are weighed to be dissolved in a PBS solution, and the dissolved methacrylate anhydride gelatin monomers are oscillated and dissolved at 37-50 DEG C in the dark; a lithium phenyl-2,4,6-trimethylbenzoylphosphonate blue light initiator is weighed to be mixed with the prepared GelMA solution at room temperature in the dark, and the solution is filtered into a sterile centrifuge tube with a sterile filter;and the related polypeptides or Abaloparatide is added to the sterile centrifuge tube containing the solution, and then the mixed solution is irradiated with a blue light source and cured into the hydrogel of any shapes. Effective entrapment and release of the Abaloparatide and PTH1-34 drugs are conducted and a cumulative release rate reaches approximately 86% on the 12th day. The hydrogel is also applied in cavity locally filled stent materials or applied for repairing and filling bone defects caused by osteoporotic fractures.

The invention relates to 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7B(PDE7B). Diseases and conditions mediated by PDE7B include osteoporosis, osteopenia and asthma.

Resorbable calciumphosphate (CaP) based compositions comprising growth and differentiation factors (GDF) and their uses in bone regeneration and preventive treatment, in particular of osteoporotic bone, are disclosed.

A system and method are provided to optically track a subject's anatomy without the need for the use of invasive pins and screws currently used to support and attach six-degree-of-freedom fiducial arrays directly to the bone. The system and method is especially advantageous for surgical procedures involving brittle or osteoporotic bone or any other procedure where the preservation of surrounding healthy bone is desirable. The system and method are advantageous for computer-assisted total knee arthroplasty, revision knee arthroplasty, and other medical procedures where the position and orientation (POSE) of bone surface cuts planes are critical for successful placement and correct alignments of joint implants. Often, these procedures require a form of external support to reduce the motion of the bones relative to the computer-assisted device.

A plate having unique anatomical brim specific shape and enables dual cortical fixation i.e. fixation from outer cortical region and inner cortical region, in a quick and easy manner is disclosed. Dual cortical fixation using nut and bolt enables compression (grip), enabling repair of fractures in normal as well as osteoporotic bone. The plate rests on to brim of pelvic so that a single screw or more screws can be inserted into it from the outer cortex of the bone that comes out of the brim, as brim is the strongest portion and holds the screws well. The screws are held into the bone using bi-cortical fixation by means of cannulated screws which are provided with washers to increase surface area of contact with bone. Owing to ease of use, the plate drastically reduces surgery time from fewhours to less than an hour.

The present invention provides methods for treating physical conditions resulting from postmenopausal estrogen decline in a postmenopausal subject, and in particular methods for reducing the risk of osteoporotic bone fractures in a postmenopausal subject. The present invention also provides a kit useful for carrying out the methods of the present invention