A valve activation assembly which mechanically collapses a collapsible member, such as a buckling pin, in response to both overpressure and underpressure conditions of a pressurized fluid. A retention member retains the valve member in a selected position with respect to the fluid, such as an open or closed position. A piston assembly is configured to mechanically collapse the collapsible member both when a fluidic pressure upon the piston assembly exceeds a first level, and when a fluidic pressure upon the piston assembly falls below a second level. Upon collapse of the collapsible member, the valve member releases the valve member, allowing the valve member to move to a different selected position (such as closed or open, respectively). A third piston member and a biasing member thereon can also be utilized. In some embodiments, a fluid is preferably held in compression between selected piston members.