New application of statin compound as topical medicine for preventing and curing osteoporotic fracture

Abstract

The invention discloses a new application of statin compound as topical medicine for preventing and curing osteoporotic fracture and enhancing bone plant strength in osteoporotic bone, particularly, discloses a topical statin composite for bone. The topical statin composite can increase bone mass, improve bone density, improve bone tissue microstructure and enhance bone mechanical property, thereby being used for preventing and curing osteoporotic fracture and enhancing the bone plant strength in osteoporotic bone.

Description

technical field [0001] The present invention relates to the field of medical technology, more specifically, relates to the local application of HMG-CoA reductase inhibitors (statins) to prevent and treat osteoporotic fractures, enhance the internal fixation strength of osteoporotic bones, and promote new uses such as fracture healing, and Its topical composition. Background technique [0002] Osteoporosis is a systemic disease characterized by low bone mass and microarchitectural disruption of bone tissue, leading to increased bone fragility and susceptibility to fractures. [0003] With the extension of human life span and the increase of postmenopausal women, osteoporosis and its associated fractures have become a serious public health problem worldwide. Taking the most serious hip fracture as an example, the global incidence in 1990 was 1.66 million, and it is expected to reach 6.26 million in 2050, of which Asia accounts for about 51%. [0004] Although osteoporosis is...

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Problems solved by technology

The bioavailability of statins after oral administration is low. After the first-pass effect of the liver, less than 5% enter the blood circulation, and the concentration in the bones is even lower (Schachter M. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam Clin Pharmacol.2005; 19(1): 117-125.), it is difficult to exert effective osteogenesis

[0011] Secondly, many patients with osteoporosis clinically need internal fixation surgery, but loose bones are a huge obstacle to the success of surgery

When internal fixation surgery is required for osteoporosis patients' fractures, spinal degenerative changes, and osteoarthritis, the fragile bones are difficult to guarantee the curative effect of surgery; many patients have not received osteoporosis treatment before surgery, and the existing Osteoporosis Drugs Only Slow Bone Loss, Not Emergency

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