The invention discloses a momordica grosvenori wine, which is prepared from the raw material of fresh and dried momordica grosvenori, by the processes of: triturating the momordica grosvenori, boiling, cooling, adding distiller's yeast, fermentating, distilling, and cooling. Wherein, in the distilling process, 3-10% of fresh or dried momordica grosvenori is added for distillation; the distiller'syeast is rhizopus, and the using amount is 1.5-6% of the raw materials. The invention has the advantages of simple production process, low technology difficulty, no added grain, and low investment; The momordica grosvenori wine has a low alcohol degree, is suitable for the people having alcohol addiction, will not cause alcohol accumulation poisoning; and the invention causes little loss to the active ingredients of the momordica grosvenori, such as mogroside, flavones, and VC, guarantees the health care efficacies of the momordica grosvenori, and has a broad market prospect and high economicdevelopment value.