The invention discloses a seven-element high-entropy alloy coating prepared by laser cladding and a preparation method thereof, belonging to the technical field of alloy surface coating modification; the high-entropy alloy powders are Al, Co, Cr, Fe, Mo, V, Ti . The matrix material is Ti-6Al-l4V (TC4) titanium alloy, and the atomic fraction of each raw material in the high-entropy alloy powder is Al (10%-16%), Co (11%-15%), Cr (9%-16%) ), Fe (6%-15%), Mo (8%-17%), V (8%-15%), Ti (12%-16%), the sum of all components is 100%. by CO 2 The high-energy laser beam emitted by the laser clads the configured alloy powder on the surface of the substrate to form a high-entropy alloy coating. The substrate and the cladding layer are metallurgically combined to achieve the purpose of surface modification, thereby increasing the hardness of the titanium alloy. , wear resistance and corrosion resistance, thereby extending the service life of titanium alloys.