55results about How to "Little change in content" patented technology

The invention relates to a hot compression high phosphorus iron-base diamond bit and the preparation method. The content of the diamond is 75 percent to 95 percent, the matrix materials have the component and the content that Fe powder is 35 percent to 50 percent; P is 3 percent to 6 percent; B is 1 percent to 2 percent; Ni is powder 5 percent to 10 percent; Co powder is 5 percent to 7 percent; 663-Cu powder is 25 percent to 32 percent; Mn powder is 2percent to 3 percent; Ti powder is 1 percent to 2 percent; rare earth La is 1.5 percent to 2 percent, and rare earth Ce is 1.0 percent to 1.5 percent. The preparation method comprises the procedures of material preparation, material packing and material mixture, die filling, hot-pressed sintering. The invention has the advantages that the matrix materials are widely used, and the cost is low; the sintering temperature is decreased; the hot etching of the iron to the diamond under high temperature is reduced; and the service life of the drill bit are improved; the drill bit has a broad spectrum; and the application scope is wide.

The invention discloses a dry-mixed mortar, which comprises the following components in parts by weight: 120 parts of cement, 700 to 800 parts of scree artificial sand, 80 parts of coal ash and 4 parts of additive, wherein the scree artificial sand is made of broken scree through a sand making machine or other sets of equipment; and the fineness modulus of the scree artificial sand is 2.3 to 3.0. The raw material of the dry-mixed mortar is the scree artificial sand; the particle shape and the grading of the scree artificial sand are high, and the moisture content is low, so that the scree artificial sand can be used for preparing the dry-mixed mortar without being dried; and moreover, the hardness of the scree artificial sand is greater than that of rock artificial sand, so that the dry-mixed mortar is low in cost and high in quality and has obvious economic benefit.

The invention relates to a preparation method of a high-storage-stability polyester-type polyurethane prepolymer, which comprises the following steps: adding a nitrogen-containing metallic ion complexing agent into a hydroxyl-terminated low-polymer polyester polyol; dewatering at 95-130 DEG C under the vacuum degree of 0.08-0.09 MPa for 2 hours; cooling to 30-55 DEG C, mixing with 2,4-toluene diisocyanate, and reacting at controlled temperature of 30-65 DEG C for 0.5 hour; heating to 70-95 DEG C, and keeping the reaction for 2 hours; adding a polymerization inhibitor, and deaerating at controlled temperature of 70-95 DEG C under the pressure of 0.08-0.09 MPa for 0.5 hour to obtain the high-storage-stability polyester-type polyurethane prepolymer; and after measuring that the percentage ofNCO (isocyanate-group) in the prepolymer is equivalent to a set value, cooling, charging nitrogen, and storing in a closed environment. The change rate of the percentage of NCO in the obtained polyester-type polyurethane prepolymer is less than 0.2%, and thus, the polyester-type polyurethane prepolymer can be stored stably.

The invention discloses an oily composition which is extracted from Litsea lancilimba and Blumea mollis and contains 1, 8-eudesmin and blumeatin. The oily composition is oily substance extracted from the Litsea lancilimba and the Blumea mollis. The main compositions by weight percentage of the oily composition are: 2.01 to 19.61 percent of the 1, 8-eudesmin, 0.2 to 9.40 percent of sabinene, 0.40 to 4.71 percent of alpha-pinene, 0.40 to 7.84 percent of lemonene, 0.21 to 8.27 percent of the blumeatin, 1.66 to 23.95 percent of L-camphol and 0.64 to 7.98 percent of beta-caryophyllene. The oily composition is definite in main active ingredients, small in content variation, stable in quality which can be effectively controlled, and reliable in healing effect. The invention also discloses use of the oily composition.

The invention provides a carbohydrate and electrolyte injection which comprises the following components by weight part: 30 parts of glucose, 15 parts of fructose, 7.5 parts of xylitol, 0.73 part of sodium chloride, 0.41 part of sodium acetate, 0.185 part of calcium chloride, 0.255 part of magnesium chloride, 0.87 part of dipotassium phosphate, 0.0007 part of zinc sulfate, 0.21 part of sodium bisulfite and 250 parts of water for injection; and the PH value is 5.1-5.5. The injection is low in cost and wide in applicable range. The invention also provides a preparation method of the carbohydrate and electrolyte injection. The preparation method comprises the steps of dissolving carbohydrate and electrolyte (as raw and auxiliary materials), absorbing, decarbonizing, adjusting the pH, and sterilizing to obtain the carbohydrate and electrolyte injection. According to the preparation method, the process is simple, the method is suitable for industrial production, the problems that samples turn yellow after the sterilization, and white substances are separated out can be avoided by increasing the dissolving temperature to be 75 DEG C-85 DEG C and adjusting the pH of the solution, so thatthe carbohydrate and electrolyte injection is stable.

The invention aims to provide perfume capable of reducing and even avoiding the volatizing of effective components. The perfume comprises, by weight, 75-90 parts of ethanol, 3-7 parts of water, 5-20 parts of glycerin-natural perfume mixture, wherein the glycerin-natural perfume mixture comprises 10-20wt% of glycerin and 80-90wt% of natural perfume. The perfume has the advantages that the difference of the effective component content of the natural perfume in the perfume of different batches is small, perfume quality can be controlled favorably, and large-scale production of high-end perfume is benefited; meanwhile, the raw material source of the perfume is strictly controlled, the perfume is natural and nonirritant, the skincare possibility of the perfume is increased, and the perfume has a certain anti-allergic effect.

The invention belongs to the technical field of pharmaceutical preparations and in particular relates to a hydroxyfasudil pharmaceutical composition. The hydroxyfasudil pharmaceutical composition has a dosage form of an injection and is characterized by comprising sodium citrate which is capable of preventing change of insoluble particles in the process of preparation placement and guaranteeing the stability and the safety of a preparation.

The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a stable adenosine cyclophosphate pharmaceutical composition which is characterized by being used for preparing an injection, wherein the solubilization ingredient is the combination of sodium hydroxide and PEG400 (polyethylene glycol 400). The injection prepared by the invention has the advantage of prominently improved stability.

The invention relates to a smelting method of bearing steel, in particular to a preparation method of the bearing steel with the low titanium content. The bearing steel comprises, by mass, no more than 0.0018% of Ti, more than 0.4% of Si (preferably, 0.4-0.6%), and more than 0.9% of C (preferably, 0.90-1.00%). The preparation method comprises the steps of primary smelting, fine smelting, vacuum degassing, pouring and rolling. According to the preparation method, the problem that the titanium content of a bearing steel product is too high is solved under the condition that the smelting cost isnot increased.

The invention belongs to the technical field of medicine preparations and particularly relates to fluconazole tablets and a preparation method thereof. The fluconazole tablets comprise the following raw materials in parts by weight: 40 to 50 parts of fluconazole, 15 to 40 parts of a filling agent, 2 to 15 parts of a disintegrating agent, 5 to 10 parts of an adhesive and 0.2 to 2 parts of a lubricant, wherein the filling agent comprises sodium alginate, microcrystalline cellulose and anhydrous calcium hydrogen phosphate; the disintegrating agent comprises croscarmellose sodium; the adhesive ispovidone K30; and the lubricant is magnesium stearate. The fluconazole tablets have the advantages of high compressibility, controllable friability and dissolubility, rapidness in disintegration, excellent stability and dissolution performance, high bioequivalence and high bioavailability.

The invention discloses a medical lansoprazole composition for treating gastric ulcer, and belongs to the technical field of medicines. The composition comprises a tablet core, an isolating layer and an enteric coated layer, wherein the tablet core is prepared from a lansoprazole crystal, lactose, microcrystalline cellulose, carboxymethyl starch sodium, calcium hydrophosphate, hydroxypropyl methylcellulose, purified water, lauryl sodium sulfate and silicon dioxide; the isolating layer is prepared by dissolving a film coating premixing agent into 95% ethanol; the enteric coated layer is prepared by dissolving opadry into 95% ethanol. The lansoprazole crystal compound is free of impurity E; the contents of impurity A and impurity B are obviously reduced and changed a little as the storage time goes on; the composition is outstanding in mobility, and the dissolution rate is obviously improved.

The present invention provides a conjugated polyelectrolyte, and a preparation method therefor and a biological application thereof. The conjugated polyelectrolyte has a chemical structure as shown in the formula I, wherein m is an integer whose value is 2-12, n is an integer whose value is 10-100, and Et is an ethly. The conjugated polyelectrolyte has good cell compatibility, low toxicity and excellent optical physical properties (such as high brightness and high optical stability), and is sensitive to ATP response, and can be effectively used for cell imaging or ATP semi-quantitative detection. The formula I is as shown in the specification.

The invention belongs to the technical field of medicines, and discloses a palbociclib crystalline compound and a preparation method thereof. An X-ray powder diffraction spectrum represented by a diffraction angle of 2theta plus / minus 0.2 degree displays characteristic diffraction peaks at the positions of 3.21 degrees, 5.62 degrees, 6.53 degrees, 9.12 degrees, 13.41 degrees, 14.43 degrees, 15.53 degrees, 21.72 degrees, 24.61 degrees and 27.71 degrees; the X-ray powder diffraction spectrum obtained by measuring with Cu-Kalpha rays is as shown in Figure 1, and is totally different from that in the prior art. The palbociclib crystalline compound has better water solubility and higher stability, the preparation method is simple and easy to operate, after the palbociclib crystalline compound is prepared into a drug composition, the drug use safety is greatly improved, and the drug composition is very suitable for clinic application.

The invention relates to a smelting method of bearing steel, in particular to a preparation method of the bearing steel with the low titanium content. The bearing steel comprises, by mass, no more than 0.0018% of Ti, more than 0.4% of Si (preferably, 0.4-0.6%), and more than 0.9% of C (preferably, 0.90-1.00%). The preparation method comprises the steps of primary smelting, fine smelting, vacuum degassing, pouring and rolling. According to the preparation method, the problem that the titanium content of a bearing steel product is too high is solved under the condition that the smelting cost isnot increased.

The invention relates to pharmaceutical lansoprazole composite granules for treating digestive system diseases and belongs to the technical field of medicine. The granules are made from lansoprazole, cane sugar, anhydrous sodium carbonate, croscarmellose sodium, nordihydroguaiaretic acid, 95% ethyl alcohol and talcum powder. The lansoprazole is a new crystal form compound, an X-ray powder diffraction pattern of the lansoprazole measured by using Cu-Ka ray is shown in figure 1, the lansoprazole is different from those reported in the prior art, experiments show that the lansoprazole, the new crystal form compound, provided by the invention has no impurity E, in the lansoprazole, the contents of impurity A and impurity B are evidently decreased and slightly change over storage time, the lansoprazole has good fluidity and evidently improved solubility, and the lansoprazole granules made using the new crystal form compound are good in stability and low in impurity content.

The invention relates to a preparation method of a high-storage-stability polyester-type polyurethane prepolymer, which comprises the following steps: adding a nitrogen-containing metallic ion complexing agent into a hydroxyl-terminated low-polymer polyester polyol; dewatering at 95-130 DEG C under the vacuum degree of 0.08-0.09 MPa for 2 hours; cooling to 30-55 DEG C, mixing with 2,4-toluene diisocyanate, and reacting at controlled temperature of 30-65 DEG C for 0.5 hour; heating to 70-95 DEG C, and keeping the reaction for 2 hours; adding a polymerization inhibitor, and deaerating at controlled temperature of 70-95 DEG C under the pressure of 0.08-0.09 MPa for 0.5 hour to obtain the high-storage-stability polyester-type polyurethane prepolymer; and after measuring that the percentage of NCO (isocyanate-group) in the prepolymer is equivalent to a set value, cooling, charging nitrogen, and storing in a closed environment. The change rate of the percentage of NCO in the obtained polyester-type polyurethane prepolymer is less than 0.2%, and thus, the polyester-type polyurethane prepolymer can be stored stably.

The invention provides glaucescent fissistigma root granules and a preparation method thereof. The method comprises the following steps of: crushing glaucescent fissistigma roots, performing ethanol extraction in a water bath, concentrating to obtain extract, performing freeze drying, mixing the extract and auxiliary materials, preparing a soft material, preparing the granules, drying and reshaping the granules, and inspecting. The glaucescent fissistigma root granules contain 5 to 20 weight parts of glaucescent fissistigma root extract powder, 50 to 80 weight parts of sucrose, 10 to 30 weight parts of dextrin, and 5 to 10 weight parts of sodium carboxymethylcellulose. The invention has the advantages that: the glaucescent fissistigma roots serving as a Chinese medicinal herb are prepared into the granules, so that the active ingredients of the glaucescent fissistigma roots are reserved, the granules are convenient to drink, and the preparation method is suitable for industrialized production.

The invention discloses a PET material injection molding device and a using method thereof, and belongs to the field of PET material injection molding. According to the scheme, after a feeding hopper body is externally connected with a feeding mechanism, moisture in the feeding hopper body is absorbed through heating evaporation of a heating mechanism in cooperation with moisture absorption powder in a moisture absorption ball, and the moisture content in air is reduced; meanwhile, in the conveying process of a PET material, a sliding block is in sliding fit with an L-shaped pipe in a sliding groove to blow the moisture absorption ball to swing under the assistance of an elastic connecting rope, and therefore the moisture absorption powder makes more comprehensive contact with the moisture in the air; and the color change of a water-based silk-screen printing ink coating is observed through a camera, people can conveniently know the content change of the moisture in the air in time, the pressure intensity is reduced due to the fact that the moisture in the air is reduced, hot air generated in the injection molding process of a fixed mold and a movable mold is supplemented through an air guide pipe, the temperature in the feeding hopper body is increased, further evaporation of the moisture is guaranteed, and melting of the PET material is accelerated.

The invention belongs to the medical technical field and particularly relates to a lansoprazole or dextral lansoprazole crystal type compound and a preparation method thereof. The lansoprazole or dextral lansoprazole crystal type compound is trihydrate crystal, the molecular formula of the lansoprazole or dextral lansoprazole crystal type compound is as follows, the strutral formula of the lansoprazole or dextral lansoprazole crystal type compound is as follows, and an X-ray powder diffraction spectrum which is obtained through the formula ray measurement is as follows. The lansoprazole or dextral lansoprazole crystal type compound is free of impurity E, and the content of impurities A and impurities B is significantly reduced, the change of the content of the impurities A and the impurities B is small along with the extension of the storage time, the liquidity is excellent, and the dissolution rate is significantly improved.

The invention provides a carbohydrate and electrolyte injection which comprises the following components by weight part: 30 parts of glucose, 15 parts of fructose, 7.5 parts of xylitol, 0.73 part of sodium chloride, 0.41 part of sodium acetate, 0.185 part of calcium chloride, 0.255 part of magnesium chloride, 0.87 part of dipotassium phosphate, 0.0007 part of zinc sulfate, 0.21 part of sodium bisulfite and 250 parts of water for injection; and the PH value is 5.1-5.5. The injection is low in cost and wide in applicable range. The invention also provides a preparation method of the carbohydrate and electrolyte injection. The preparation method comprises the steps of dissolving carbohydrate and electrolyte (as raw and auxiliary materials), absorbing, decarbonizing, adjusting the pH, and sterilizing to obtain the carbohydrate and electrolyte injection. According to the preparation method, the process is simple, the method is suitable for industrial production, the problems that samples turn yellow after the sterilization, and white substances are separated out can be avoided by increasing the dissolving temperature to be 75 DEG C-85 DEG C and adjusting the pH of the solution, so that the carbohydrate and electrolyte injection is stable.

In view of the actuality of large PCBs polluted site area, serious contamination, difficult restoration and shortage of restoration technology in our country, the invention provides a new technology for rapid extraction of persistent organic pollutants from polluted soil so as to realize the reclamation and reuse of such soil. The technology is characterized in that: in an airtight reaction kettle, a special organic solvent is employed as the extracting agent, and by taking advantage of the characteristic that the solvent can rapidly dissolve organic pollutants under an increased temperature and an increased pressure, the efficient separation of the organic pollutants and soil can be realized. The technology of the invention has the advantages of simple operation, short process, high efficiency, small amount of solvent consumption and the like, and the treated soil changes little in the content of organic matters, thus being applicable for backfilling and reclamation.

The invention relates to a medicine lansoprazole compound dry suspension treating gastropathy, and belongs to the technical field of medicine. The compound dry suspension is prepared from lansoprazole, lactose, mannitol, disodium hydrogen phosphate, xanthan gum, sucralose and silicon dioxide. The lansoprazole is a new crystal type compound. An X-ray powder diffraction diagram obtained through Cu-Kalpha ray measurement is shown as the figure 1. The lansoprazole is different from lansoprazole reported in the prior art. As is found through a test, the lansoprazole crystal compound does not contain an impurity E, the content of an impurity A and the content of an impurity B are obviously reduced, and besides the content changes little along with prolonging of storage time. The dry suspension has good flowability and remarkably improves the dissolution rate, and the lansoprazole dry suspension prepared from the crystal type compound is good in stability and low in impurity content.

The invention provides a sirolimus gel preparation. The preparation does not use a conventional stabilizer, and the sirolimus gel preparation with better stability is obtained by optimizing components of the gel preparation and controlling the dosage of ethanol and the pH value of a prescription. The conventional lofting data of the preparation shows that the content change of the active substance sirolimus is small, and the accumulative release amount can reach 99.40% at most after 3-hour in-vitro release.

The invention discloses a method of using modified enteromorpha charcoal to remove antibiotics in aquaculture water. The size of modified enteromorpha is 0.08 to 0.15 mm, the specific surface area is3214 m2 / g, and the total pore volume is 1.302 cm3 / g. The modified enteromorpha charcoal can be used to remove antibiotics in aquaculture water, is capable of being regenerated, and can be used to adsorb antibiotic pollutants for many times. The coal resource is saved, and the cost is largely reduced. As the concentration of modified enteromorpha charcoal increases, the contents of ciprofloxacin, norfloxacin, sulfafurazole, and roxithromycin in aquaculture water decrease continuously. When the concentration of modified enteromorpha charcoal reaches 25 g / L, the contents of ciprofloxacin and roxithromycin in aquaculture water become stable; when the concentration of modified enteromorpha charcoal reaches 30 g / L, the contents of norfloxacin and sulfafurazole in aquaculture water become stable;the contents of antibiotics barely change, even if the concentration of modified enteromorpha charcoal increases, and the removal rate is in a range of 32-51%.

The invention discloses sodium aescinate liniment. The sodium aescinate liniment is prepared from components as follows: 0.1%-2% of sodium aescinate, 0.1%-5% of a thickening agent, 1%-5% of a penetration enhancer and the balance of a solvent with the pH being 5-6. The sodium aescinate liniment has the advantages of good transdermal absorption effect, good stability, low irritation to skin and the like.

The invention discloses a pharmaceutical lansoprazole compound for treating gastric ulcer, belongs to the field of medicines and particularly relates to a lansoprazole compound and a preparation method thereof. The lansoprazole compound is measured with a Cu-K alpha ray to obtain an X-ray powder diffraction diagram shown in Figure 1. The crystal lansoprazole compound provided by the invention contains no impurity E, the contents of impurities A and B are remarkably reduced and change a little as the storage time increases, and the lansoprazole compound has superior fluidity and is remarkably improved in dissolution rate.

The invention relates to a preparation method of a fleece-flower root swelling product, which comprises the following concrete steps: A, cleaning fresh fleece-flower root medicinal material, and chopping into particles with the size of 0.5-1.0 centimeter; B, heating the fleece-flower root particles of the step A at 50-60 DEG C, so that the moisture content is 10-20%; C, carrying out swelling processing on the fleece-flower root particle heated in the step B by a screw rod food extruding swelling machine, wherein the rotation speed of the swelling machine is 200-300r / min, and the swelling temperature is 120-150 DEG C, and obtaining the swelling product; and D, cooling the swelling product of the step C for 5-10 minutes, and packing. The method of the invention has simple operation and convenient processing, and the prepared fleece-flower root product has high bioavailability, loose texture, good taste, thick flavor and convenient taking.

The invention provides a molecularly imprinted monodisperse microsphere with a specific adsorption function for tobacco-specific nitrosamines, characterized in that the molecularly imprinted monodisperse microsphere uses nicotinamide as a template molecule and methacrylic acid As a functional monomer, trimethylolpropane trimethacrylate is used as a cross-linking agent, polystyrene emulsion is used as a seed ball, and phthalic acid is used as a swelling agent. It is synthesized by swelling polymerization and provides this molecule Preparation and application of imprinted monodisperse microspheres. In the molecularly imprinted monodisperse microspheres provided by the invention, the particles are uniform, the dispersibility is good, and it has a specific adsorption effect on tobacco-specific nitrosamines, which can effectively reduce the toxic components in cigarettes without significantly affecting their original quality. .

The invention discloses a preparation method of a composite beverage unique in taste. The preparation method comprises the following steps of uniformly mixing mulberries with pretreated purple corn, loquat pulp, sodium gluconate and malt sugar, performing homogenizing treatment, adding water, performing uniform mixing, performing filtration, adding cyclodextrine to filtrate, performing uniform mixing, performing filling, and performing high-temperature sterilization so as to obtain the composite beverage unique in taste. The pretreated purple corn is prepared through the following technology: feeding purple corn into water, soaking the purple corn, adding purple corn cover leaves, performing mixing, performing grinding, performing warming, performing stirring, performing cooling, adding pullulanase, performing enzymolysis, performing inactivation, and performing filtration so as to obtain the pretreated purple corn. Through the adoption of the preparation method disclosed by the invention, the comprehensive utilization of the purple corn is realized, the edible parts of the purple corn are utilized, and purple parts rich in anthocyanidin, of the cover leaves of the purple corn are fully utilized; and after the purple corn is organically combined with other raw materials, the obtained beverage has unique flavor, effective components in raw materials can be well reserved, besides, the obtained beverage is rich in anthocyanidin, purplish red in color, free from any artificial color ingredients, and good in flavor and mouth feel.