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Molecularly imprinted monodisperse microspheres with specific adsorption function for tobacco-specific nitrosamines and its preparation and application

A monodisperse microsphere and molecular imprinting technology, applied in the field of tobacco, can solve the problems of high attention and vigilance of TSNAs, and achieve the effect of improving safety and reducing toxic effects.

Active Publication Date: 2016-08-10
CHINA TOBACCO GUANGDONG IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the formation process of TSNAs has not been fully clarified, the governments of Canada, the United States and Brazil have clearly required tobacco manufacturers to provide the contents of NNN, NNK, NAB and NAT in the mainstream smoke of brands with a market share of more than 2%. It is difficult to see that the world tobacco industry attaches great importance and vigilance to TSNAs

Method used

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  • Molecularly imprinted monodisperse microspheres with specific adsorption function for tobacco-specific nitrosamines and its preparation and application
  • Molecularly imprinted monodisperse microspheres with specific adsorption function for tobacco-specific nitrosamines and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Synthesis of MIMPMs by two-step swelling polymerization

[0033] Preparation of bulb emulsion: In a 1000mL three-necked bottle, add 0.4g initiator potassium persulfate (KPA), 0.4gNaCl, 270mL distilled water and 60mL50% styrene ethanol solution, under mechanical stirring (rotation speed: 400r / min), Pass N 2 Polymerization at 70°C for 12h. After the reaction is complete, continue to pass N 2 10min, remove the residual styrene monomer, and obtain the spherical polystyrene (PS) emulsion;

[0034] The first step of swelling: In a 250mL Erlenmeyer flask, add 1gAIBN, 15mLDBP, 15mL toluene and 80mL0.15%SDS solution, after ultrasonication for 5min, add to the emulsion made of 40mLPS emulsion and 320mL0.15%SDS solution, at room temperature Swell for 24h;

[0035] The second step of swelling: Dissolve 3mmolNAM and 18mmolMAA in 32mL of toluene. After ultrasonication for 30mim, add it to the emulsion made of 75mmolLTRIM and 60mL1.75%PVA solution. Swell for 24h;

[0036] Pol...

Embodiment 2

[0039] 1. Synthesis of MIMPMs by two-step swelling polymerization

[0040] Preparation of bulb emulsion: In a 250mL three-necked bottle, add 0.1g initiator potassium persulfate (KPA), 0.2gNaCl, 90mL distilled water and 20mL 50% styrene ethanol solution, under mechanical stirring (speed 200r / min), Pass N 2 Polymerization at 70°C for 12h. After the reaction is complete, continue to pass N 2 10min, remove the residual styrene monomer, and obtain the spherical polystyrene (PS) emulsion;

[0041] The first step of swelling: In a 50mL Erlenmeyer flask, add 100mgAIBN, 2mLDBP, 2mL toluene and 20mL0.35%SDS solution, after ultrasonication for 5min, add to the emulsion made of 10mLPS emulsion and 20mL0.35%SDS solution, at room temperature Swell for 48h;

[0042] The second step of swelling: Dissolve 1mmolNAM and 6mmolMAA in 8mL of toluene, after ultrasonication for 30mim, add it to the emulsion made of 20mmolLTRIM and 20mL1.25%PVA solution, add it to the swelling solution of the firs...

Embodiment 3

[0046] 1. Synthesis of MIMPMs by two-step swelling polymerization

[0047] Preparation of bulb emulsion: In a 500mL three-necked bottle, add 0.15g initiator potassium persulfate (KPA), 0.3gNaCl, 160mL distilled water and 40mL45% styrene ethanol solution, and mechanically stir (rotating at 300r / min), Pass N 2 Polymerization at 70°C for 12h. After the reaction is complete, continue to pass N 2 10min, remove the residual styrene monomer, and obtain the spherical polystyrene (PS) emulsion;

[0048] The first step of swelling: In a 150mL Erlenmeyer flask, add 200mgAIBN, 6mLDBP, 8mL toluene and 40mL0.2%SDS solution, after ultrasonication for 5min, add to the emulsion made of 30mLPS emulsion and 40mL0.2%SDS solution, at room temperature Swell for 36h;

[0049] The second step of swelling: Dissolve 1.5mmol NAM and 7.5mmol MAA in 16mL of toluene. After ultrasonication for 50mim, add it to the emulsion made of 50mmolLTRIM and 50mL1.55%PVA solution. Re-swell for 12h;

[0050] Polym...

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Abstract

The invention provides a molecularly imprinted monodisperse microsphere with a specific adsorption function for tobacco-specific nitrosamines, characterized in that the molecularly imprinted monodisperse microsphere uses nicotinamide as a template molecule and methacrylic acid As a functional monomer, trimethylolpropane trimethacrylate is used as a cross-linking agent, polystyrene emulsion is used as a seed ball, and phthalic acid is used as a swelling agent. It is synthesized by swelling polymerization and provides this molecule Preparation and application of imprinted monodisperse microspheres. In the molecularly imprinted monodisperse microspheres provided by the invention, the particles are uniform, the dispersibility is good, and it has a specific adsorption effect on tobacco-specific nitrosamines, which can effectively reduce the toxic components in cigarettes without significantly affecting their original quality. .

Description

technical field [0001] The present invention relates to the field of tobacco, and more specifically relates to a molecularly imprinted monodisperse microsphere with specific adsorption function for tobacco-specific nitrosamines and its preparation and application. Background technique [0002] The tobacco epidemic is one of the biggest public health threats the world has faced so far. There are more than 1.1 billion people smoking in the world, and the tobacco consumption in developing countries is increasing year by year. As people pay more and more attention to smoking and health issues, the safety of smoking has been paid more and more attention, and it is particularly important to improve the safety of cigarettes. [0003] Tobacco smoke contains more than 7,000 chemical components, hundreds of which are harmful substances, and at least 69 are known carcinogens, including N-nitrosoamines, fused-ring aromatic hydrocarbons, and aromatic amines. Tobacco-specific nitrosamine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F257/02C08F222/14C08F220/06C08J9/26B01J20/26B01J20/28A24D3/14
Inventor 吴亦集朱全红陶红罗佳波邢学锋沈光林谭晓梅
Owner CHINA TOBACCO GUANGDONG IND
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