49results about How to "Increase drug release rate" patented technology

A method of enhancing the drug release rate from a composite material. The composite material includes a synthetic, bioabsorbable polymer matrix and a drug particle phase dispersed therein. The release rate of the drug from the polymer matrix is enhanced by orienting the composite material. The drug release rate of the oriented composite material is greater than the drug release rate from an otherwise comparable non-oriented composite material.

The invention relates to electric filature to produce a kind of nano fiber growth gene slow-release system. This invention is compounded by biology decomposably polymer material and uses electric filature to produce a kind of nano fiber laxyly release system which contains growth gene. The method not only is operated easily and has a simple working procedure, but also can use the growth gene effectively in reducing the absent tissues. The laxly release system can emit growth gene steadily in body and avoids the lost of active of growth gene. More over, it can promote increasing of cells and tissue recovery. The production can not only be mad into the piece of velamen to transplant in the absent tissues for cure, but also be made into tissue engineering shelves to plant on cells and also be fostered out of body to increase cells for the tissue's renovation and then be transplanted in body to repair tissues.

The invention discloses a lansoprazole nano-particle frozen preparation for injection capable of simultaneously improving the stability and dissolubility, and a preparation method thereof. The preparation comprises the following components in parts by weight: 20-40 parts of lansoprazole, 5-50 parts of dextran, 5-40 parts of sodium sulfite, 5-60 parts of solubilizer, 10-100 parts of nano-carrier material and 10-100 parts of freeze drying excipient. The preparation method comprises the steps of: adding the dextran, the solubilizer and the sodium sulfite into a liquid preparation tank, adding water for injection and stirring until dissolved, regulating the pH value, adding the lansoprazole and the nano-carrier material, continuing to stir evenly, adding the freeze drying excipient and stirring until dissolved, supplementing the water for injection to the full dose, decoloring, finely filtering, subpackaging and freeze drying to obtain the frozen preparation.

A biodegradable hydrogel with multiple target location function in colon is prepared from the aqueous solution of konjak glucomannan and acrylic through graft copolymerizing under the action of redox trigger and azo compound as cross-linking agent. It can be used as the carrier of protein polypeptide medicine for locating in the colon and releasing the medicine.

The invention discloses a preparation method of a tumor targeted photothermal therapy nanocarrier. The method comprises steps as follows: with GO as a carrier, loading MoS2 on GO with a hydrothermal method, and performing PEG modification to obtain the GO-MoS2 composite carrier. A composite of GO and MoS2 is taken as a phototherapeutic drug carrier for the first time, the preparation method is simple and convenient, and conditions are mild; the prepared GO-MoS2 drug-carrying composite has good photothermal conversion characteristic and higher drug carrying ratio which is higher than or equal to 80%. The drug release rate of the GO-MoS2 drug-carrying composite is 78% under laser power of 1.8 W / cm<2> in the presence of NIR laser. Compared with a conventional photothermal therapy nano-drug carrier, the GO-MoS2 drug-carrying composite has higher photo-thermal conversion rate due to synergistic effect of the two materials.

Provided is a pharmaceutical composition for the treatment and prevention of cardiac diseases, containing (a) a therapeutically effective amount of a compound represented by Formula 1 or 2 or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and (b) a pharmaceutically acceptable carrier, diluent or excipient or any combination thereof.

The invention discloses a preparation method of a collagen cladded carbon nano-tube composite material and relates to a carbon nano-tube material. The preparation method is a preparation method for preparing the collagen cladded carbon nano-tube composite material by in-situ cladding a collagen layer on the surface of a functionalized carbon nano-tube by combing a magnetic liquid phase stirring method and a hydrogel method. The preparation method comprises the following steps of preparing carbon nano-tube-hydroxyapatite composite powder; preparing the functionalized carbon nano-tube; and preparing the collagen cladded carbon nano-tube composite material by the technical method of combing the magnetic liquid phase stirring method and a hydrogel method. The defects that the carbon nano-tube is easily agglomerated, uniform dispersion of components is difficult and production efficiency is low in the preparation method of a collagen-carbon nano-tube composite material in the prior art are overcome; and when the prepared collagen-carbon nano-tube composite material is used as a medicine carrying material, the detects that the biocompatibility is still relatively poor, medicine-carrying and medicine-releasing abilities are poor, and hidden danger of toxin is not thoroughly eliminated generally are overcome.

The invention discloses a nano ganciclovir freeze-drying preparation for injection and a preparation method thereof. The nano ganciclovir freeze-drying preparation for injection comprises the following components in parts by weight: 100-400 parts of ganciclovir, 10-50 parts of dextran 40, 5-50 parts of solubilizer, 10-100 parts of nano carrier material and 10-80 parts of freeze-drying skeleton agent. The preparation method comprises the following steps of: sequentially adding dextran 40, solubilizer, ganciclovir, nano carrier material and freeze-drying skeleton agent into water for injection to be dissolved, filtering a solution step by step, and carrying out freeze-drying, thus a freeze-drying preparation is obtained. According to the preparation method, no activated carbon is introduced, thus a risk that damage is done to a human body when activated carbon particles are introduced into the preparation as the activated carbon is used is avoided; besides, pH of the nano ganciclovir freeze-drying preparation for injection is 6-8 and close to that of plasma, and local irritation produced to the human body owning to overhigh alkalinity is avoided.

A drug-loaded microparticle is applied to a medical device for subsequent application to biological tissues. A method of formulating a drug-loaded microparticle and applying it to the surface of a medical device, such as a stent, is disclosed. The drug-loaded microparticle is formulated by combining a drug with various chemical solutions. Specified sizes of the microparticles and amounts of drug(s) contained within the microparticles may be varied by altering the proportions of the chemicals / solutions. In addition to various drugs, therapeutic substances and radioactive isotopes may also be loaded into the microparticles. The drug-loaded microparticle are suspended in a polymer solution forming a polymer matrix. The polymer matrix may be applied to the entire surface or only selected portions of the medical device via dipping, spraying or combinations thereof.

The invention provides a PLGA (polylactic acid-hydroxyacetic acid) nano-drug carrier which is composed of PLGA nano microsphere kernel and an anillic aldehyde crosslinked chitosan housing. A preparation method of the polylactic acid-hydroxyacetic acid copolymer nano-drug carrier is as follows: dispersing a PLGA organic phase which takes dichloromethane and alcohol as a mixed solvent in a water phase to prepare PLGA microspheres by taking PVA (polyvinyl acetate) as an emulsifier by virtue of an one-off emulsion process; then, adding the PLGA microspheres into chitosan liquor, so that the chitosan is adsorbed on the surfaces of the PLGA microspheres, and then adding the chitosan on the surfaces of anillic aldehyde crosslinked PLGA microspheres. The product has a certain pH environmental responsiveness, can realize controlled release of the drug according to in-vivo pH environmental changes, is high in stability, strong in up-taking capacity for microsphere-coated medicaments by the cells, and has very good application prospect in the drug carrier for treating tumors.

The invention provides the preparation and application of a nano-diamond drug with high load and pH-controlled release of doxorubicin. The present invention first uses H2N-PEG-COOH to modify nano-diamonds, synthesizes ND-PEG-COOH carrier, and then physically adsorbs doxorubicin under the condition of sodium citrate or sodium acetate to obtain the target drug nano-diamond-polyethylene glycol-doxorubicin Sodium citrate (ND‑PEG‑DOX / Na3Cit) or nanodiamond‑polyethylene glycol‑doxorubicin / sodium acetate (ND‑PEG‑DOX / NaAc). Through in vitro drug release experiments, MTT experiments and flow cytometry cell uptake nano-drug experiments, it was shown that ND-PEG-DOX / Na3Cit and ND-PEG-DOX / NaAc can induce tumor cell apoptosis, which can be used in the preparation of anti-tumor drugs in the application.

Implantable, injectable, insertable, or otherwise administrable compositions that form hydrogels when implanted, injected, inserted, or administered into or onto living tissues comprise a pharmaceutically effective compound wherein the pharmaceutically effective compound is a codrug, or pharmaceutically acceptable salt or prodrug thereof in admixture with a hydrogel-forming compound. The pharmaceutically effective compound may be any compound that is soluble in bodily fluids, or that forms bodily fluid-soluble adducts when exposed to bodily fluids. Exemplary compounds include analgesic, anti-inflammatory and antibiotic compounds. The hydrogel-forming compound is a biologically tolerated substance that forms a hydrogel upon exposure to bodily fluids, such as the interstitial fluid surrounding or within a joint.

The invention relates to a drug-loaded PLGA material coated with red blood cell membrane-wrapped polydopamine and its preparation and application. The red blood cell membrane, PLGA, TPGS, and DA used are all biomaterials with very good biocompatibility and will not cause toxicity to the body. The preparation method has simple operation and mild reaction conditions.

The invention discloses a nano ganciclovir freeze-drying preparation for injection and a preparation method thereof. The nano ganciclovir freeze-drying preparation for injection comprises the following components in parts by weight: 100-400 parts of ganciclovir, 10-50 parts of dextran 40, 5-50 parts of solubilizer, 10-100 parts of nano carrier material and 10-80 parts of freeze-drying skeleton agent. The preparation method comprises the following steps of: sequentially adding dextran 40, solubilizer, ganciclovir, nano carrier material and freeze-drying skeleton agent into water for injection to be dissolved, filtering a solution step by step, and carrying out freeze-drying, thus a freeze-drying preparation is obtained. According to the preparation method, no activated carbon is introduced, thus a risk that damage is done to a human body when activated carbon particles are introduced into the preparation as the activated carbon is used is avoided; besides, pH of the nano ganciclovir freeze-drying preparation for injection is 6-8 and close to that of plasma, and local irritation produced to the human body owning to overhigh alkalinity is avoided.