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Drug loading system for loading docetaxel based on oxidized single-walled carbon nanohorns

A single-walled carbon nanohorn, docetaxel technology, applied in antitumor drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of non-targeting, toxic side effects, sensitization, etc.

Inactive Publication Date: 2016-08-24
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current docetaxel preparations still have some disadvantages such as non-water solubility, non-targeting, sensitization and toxic side effects.

Method used

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  • Drug loading system for loading docetaxel based on oxidized single-walled carbon nanohorns
  • Drug loading system for loading docetaxel based on oxidized single-walled carbon nanohorns
  • Drug loading system for loading docetaxel based on oxidized single-walled carbon nanohorns

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Synthesis of complex oxSWNHs-PVP:

[0044] Add 1 mg of oxSWNHs to 5 mL of deionized water, in which the mass concentration of PVP-k30 is 10 mg / mL, ultrasonically disperse for 0.5 h, stir at 45 °C for 6 h, and centrifuge at 12500 r for 15 min to remove excess PVP-k30. The precipitate was washed by centrifugation with deionized water for 2 to 3 times, and vacuum freeze-dried to obtain the complex oxSWNHs-PVP, which can be stably dispersed in a phosphate buffer solution with pH 7.4 for 15 days. Povidone in the complex The modification content is 28%.

Embodiment 2

[0046] Synthesis of complex oxSWNHs-PVP:

[0047] Add 1mg oxSWNHs to 5mL0.01mol·L -1 In PBS (pH=7.4), the mass concentration of PVP-k30 was 40mg / mL, ultrasonically dispersed for 2h, stirred at 55°C for 18h, and centrifuged at 12500r for 15min to remove excess PVP-k30. The precipitate was washed by centrifugation with deionized water for 2 to 3 times, and vacuum freeze-dried to obtain the complex oxSWNHs-PVP, which can be stably dispersed in a phosphate buffer solution with pH 7.4 for 18 days, and povidone in the complex The modification content is 32%.

Embodiment 3

[0049] Synthesis of complex oxSWNHs-PVP:

[0050] Add 1 mg of oxSWNHs to 5 mL of deionized water, in which the mass concentration of PVP-k30 is 20 mg / mL, ultrasonically disperse for 1 h, stir at 50 °C for 12 h, and centrifuge at 12500 r for 15 min to remove excess PVP-k30. The precipitate was washed by centrifugation with deionized water for 2 to 3 times, and vacuum freeze-dried to obtain the complex oxSWNHs-PVP, which can be stably dispersed in a phosphate buffer solution with pH 7.4 for 21 days. The povidone in the complex The modification content is 30%.

[0051] The TEM characterization of the complex oxSWNHs-PVP is shown in figure 1 , see the thermogravimetric analysis diagram Figure 5 .

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Abstract

The invention relates to a method for modifying oxidized single-walled carbon nanohorns by virtue of povidone, in particular to a novel drug loading system for loading docetaxel based on a single-walled carbon nanohorn-povidone compound which is built up by virtue of a nano-precipitation method. Through non-covalent modification of the povidone on the single-walled carbon nanohorns, the dispersity and the stability of the single-walled carbon nanohorns in water and a phosphate buffer solution can be effectively improved. On the basis of a [pi]-[pi] effect, by loading an anti-tumor drug, namely the docetaxel, with the compound single-walled carbon nanohorn-povidone, the water insolubility of the docetaxel is effectively improved and biocompatibility is improved; and the drug loading system is high in drug loading rate and significant in sustained-release effects, and the application of the single-walled carbon nanohorns in the field of nano-biomedicine is expanded.

Description

technical field [0001] The invention relates to a method for modifying single-wall oxidized carbon nanohorns with povidone, and in particular to constructing a novel drug-loading system based on single-wall oxidized carbon nanohorns-povidone loaded with docetaxel by using a nano-precipitation method. The non-covalent modification of single-walled carbon oxide nanohorns by povidone can effectively improve its dispersion and stability in saline solution; the use of single-walled carbon oxide nanohorns-povidone complex to load docetaxel can The water insolubility of docetaxel is effectively improved, the drug loading rate of the system is high, the sustained release effect is realized, and the application of single-walled carbon nanohorns in the field of nanobiomedicine is expanded. Background technique [0002] Nanomedicine usually refers to a class of pharmaceutical preparations researched and developed by using nanotechnology, especially nanoscale preparation technology (inc...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K47/32A61K47/04A61K31/337A61P35/00
Inventor 钟文英赵倩李囡囡
Owner CHINA PHARM UNIV
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