A polylactic acid-glycolic acid copolymer nano drug carrier and its preparation method and application
A technology of glycolic acid copolymer and glycolic acid, which is applied in the direction of nano-medicine, nanotechnology, nanotechnology, etc., can solve the problems of poor drug absorption, weak cell uptake ability, and lack of specific binding, etc., to achieve enhanced drug Therapeutic effect, enhancement of cell uptake ability, effect of uptake ability enhancement
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0050] PLGA was dissolved in a mixed solvent of dichloromethane and ethanol with a volume ratio of 3:1 to prepare a PLGA solution with a concentration of 20 mg / mL. The above PLGA solution was dropped dropwise into 0.75% PVA aqueous solution under the condition of vortex oscillation, and was ultrasonically emulsified with an ultrasonic cell pulverizer for 60 s under the condition of ultrasonic power of 12 W, and then an equal volume of the above The PVA aqueous solution was added to the emulsion, and the organic solvent was removed by continuous stirring for 3 h, so that the nanospheres were solidified and formed, centrifuged at 4 °C and 13000 rpm for 10 min, and washed twice to obtain the product P. Aqueous acetic acid was used as a solvent to prepare chitosan solutions with concentration gradients of 1.25 mg / mL, 2.5 mg / mL and 3.75 mg / mL and adjust the pH to 6.0. Disperse the collected microspheres in the above chitosan solutions of different concentrations, stir for 3 h to ma...
Embodiment 2
[0053] Dissolving PLGA in a mixed solvent of dichloromethane and ethanol with a volume ratio of 3:1 is made into a PLGA solution with a concentration of 20 mg / mL; the chitosan aqueous solution with a concentration of 3.75 mg / mL is prepared and the pH value is adjusted to 6.0. The above PLGA solution was dropped dropwise into 0.75% PVA aqueous solution under the condition of vortex oscillation, and was ultrasonically emulsified with an ultrasonic cell pulverizer for 60 s under the condition of ultrasonic power of 12 W, and then an equal volume of the above The PVA aqueous solution was added to the emulsion, and the organic solvent was removed by continuous stirring for 3 h, so that the nanospheres were solidified and formed, centrifuged at 4 °C and 13000 rpm for 10 min, and washed twice to obtain the product P. The collected microspheres were dispersed in the above-mentioned chitosan aqueous solution, stirred continuously for 3 h to make chitosan adsorb on the PLGA microspheres...
Embodiment 3
[0056] PLGA was dissolved in a mixed solvent of dichloromethane and ethanol with a volume ratio of 3:1 to prepare a PLGA solution with a concentration of 20 mg / mL. A chitosan aqueous solution with a concentration of 3.75 mg / mL was prepared and the pH value was adjusted to 6.0. The above PLGA solution was dropped dropwise into 0.75% PVA aqueous solution under the condition of vortex oscillation, and was ultrasonically emulsified with an ultrasonic cell pulverizer for 60 s under the condition of ultrasonic power of 12 W, and then an equal volume of the above The PVA aqueous solution was added to the emulsion, and the organic solvent was removed by continuous stirring for 3 h, so that the nanospheres were solidified and formed, centrifuged at 4 °C and 13000 rpm for 10 min, and washed twice to obtain the product P. Disperse the collected microspheres in the above chitosan aqueous solution, stir continuously for 3 h to make chitosan adsorb on the PLGA microspheres, centrifuge at 4 ...
PUM
Property | Measurement | Unit |
---|---|---|
concentration | aaaaa | aaaaa |
dispersity | aaaaa | aaaaa |
dispersity | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com