The invention discloses a green synthesis method of imidazoline under visible light
catalysis, and belongs to the technical field of
organic synthesis. The preparation method comprises the following steps: 1) adding N-phenylglycine, a photocatalyst, an oxidant, a
solvent, an arylamine compound, an
aldehyde compound or an
imine compound into a dry Schlenk tube; 2) carrying out air suction and exchange operations on the reaction
bottle filled with the material for three times so as to ensure that no water or
oxygen exists in the
reaction tube and then sealing the
reaction tube; 3) placing the reaction
bottle under the
irradiation of a Blue LED, carrying out a stirring reaction, and ending the reaction when TLC detects that the
aldehyde compound disappears; and 4) transferring the reaction solution in the Schlenk tube into an eggplant-shaped
bottle, adding a proper amount of
silica gel, concentrating under reduced pressure, and purifying the obtained residue by
column chromatography to obtain the product imidazoline. Compared with the prior art, the method has the characteristics of simple synthetic
route, cheap and easily available raw materials without synthesis, simplicity and convenience in operation, environmental friendliness, mild
reaction conditions, wide substrate application range and the like.