34results about How to "Good prospects for industrial production" patented technology

The invention relates to a preparation method for a plurality of photoinitiators containing phosphorus. The preparation method comprises the steps of taking 2,4,6-trimethylphenyl halogen methane as a raw material, allowing 2,4,6-trimethylphenyl halogen methane to react with sodium phosphine to be oxidized, obtaining a phosphine oxide intermediate, finally, executing a key reaction step, namely the reaction that alpha-carbon is oxidized into ketone, and obtaining a high-yield target oxidation product through oxidation with an oxidizer under the action of a catalyst. The raw material required by the method is low in price and easy to obtain; process equipment is simple; and the method is easy to operate and low in cost.

The present invention relates to a kind of synthetic method of sofosbuvir intermediate shown in formula (I): the present invention uses compound (2S,3R)-ethyl-3-((R)-2,2-dimethyl Base-1,3-dioxolane-4-yl)-2,3-dihydroxy-2-methyl propionate (Ⅱ) as starting material, through thionyl chloride cyclization to form compound (Ⅲ ), then compound (Ⅲ) was oxidized by hydrogen peroxide / sodium tungstate to obtain compound (Ⅳ), and compound (Ⅳ) was fluorinated, hydrolyzed and benzoylated to synthesize sofosbuvir intermediate 3,5-di Benzoyl-2-deoxy-2-fluoro-2methyl-D-ribose-γ-lactone (I), the sofosbuvir intermediate synthesized by the present invention is environmentally friendly and economical, and has huge industrial production prospects.

The invention belongs to synthesis methods of ester compounds in organic chemistry and particularly relates to a method for synthesizing diakyl carbonate from biomass-based synthesis gas. Biomass-based synthesis gas obtained from biomass-based agricultural and forestry residues used as initial materials is further catalyzed to form dimethyl ether, the obtained dimethyl ether is further catalyzed to form dimethyl carbonate, then, dimethyl carbonate is subjected to transesterification with monohydric alcohol or polyhydric alcohol, and diakyl carbonate is obtained. According to the method, diakylcarbonate is produced from the cheap agricultural and forestry residues used as raw materials, the production cost is saved, environmental pollution is reduced, and a new way is provided for industrial production of diakyl carbonate and efficient and comprehensive utilization of agricultural and forestry residues, and the method has significant economic and social benefits.

The invention relates to an AC33 / nano calcium hydroxide containing organic inorganic composite material for reinforcing ancient murals and a reinforcing method. AC33 and nano calcium hydroxide are dissolved in an ethyl acetate solution. The preparation method is very simple and time-saving. The prepared mixed solution is very stable and will not precipitate for half a year, and the cost is low. The result of a mural reinforcing test shows that the composite material can play a mural reinforcing effect within 12 hours, nano calcium hydroxide is carbonized into calcium carbonate, a film formed by AC33 is broken down, and the influence of water steam exchange between murals and the environment is small. The shortages of using AC33 or nano calcium hydroxide to reinforcing a mural are overcome.Compared with the reinforcing effect of AC33 or nano calcium hydroxide, the reinforcing strength is improved by using AC33 and nano calcium hydroxide together. The composite material has a great industrial production prospect and can be used to reinforce other cultural relics such as stone relics, and the like.

The invention relates to an organogel for removing polyacrylic resin on the surface of murals based on nano-calcium hydroxide and a preparation method thereof. Nano-calcium hydroxide and epoxy resin are added into an ethyl acetate solution and stirred for 12-24 hours to form a polyacrylic resin. Acrylic cleaning gel. The preparation method is extremely simple, saves time, does not require heating and has low cost. In the preparation process, nano-calcium hydroxide reacts with ethyl acetate to generate calcium acetate as a cross-linking agent to promote gel formation. Calcium acetate is not only non-toxic, but also a food preservative, which greatly improves the safety of the gel. The experiment of removing polyacrylic resin polymer on the surface of mural shows that the removal rate can reach more than 95%. In addition, according to the amount of polyacrylic resin on the surface of the mural, the percentage of ethyl acetate can be flexibly adjusted from 70%-85% to obtain the best cleaning effect. The gel has excellent industrial production prospects, and can be extended to the cleaning of high molecular polymers on the surfaces of other cultural relics such as stone and paper cultural relics.

The invention relates to the field of medicine synthesis, and discloses a safe preparation method for 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine. The method disclosed by the invention comprises the steps: allowing 5-chloro-3-methyl-1-phenylpyrazol-4-formaldehyde to react with N-acylpiperazine under conditions of inorganic alkali such as anhydrous potassium carbonotate and anhydrous sodium carbonotate, to obtain an intermediate product with a higher yield; and allowing the intermediate product to react in the hydrochloric acid solution of n-butyl alcohol, to simutaneously remove formacyl and acyl protection group of piperazine, thereby obtaining a target product. The method has the advantages of mild conditions, higher yield, simple post-treatment, avoidance of unsafe reagents, and good industrial production prospect.

The invention relates to a preparing method of a nanometer calcium hydroxide powder material for fixing ancient murals. The preparing method comprises the steps of firstly dissolving calcium chlorideinto water, and afterwards, adding dimethyl formamide; mixing a calcium chloride aqueous solution with a sodium hydroxide aqueous solution to prepare nanometer calcium hydroxide. By means of the preparing method, heating is not needed, preparation is conducted at the normal temperature, and synthesized nanometer calcium hydroxide has high stability, and does not precipitate for 3 months in ethyl alcohol. The synthesis process is very simple, the time is saved, and it takes less than 1 h in the whole process. Besides, the method is low in synthesis cost, overcomes shortcomings of a current method of synthesizing nanometer calcium hydroxide, and has a very good industrial production prospect. As is shown by mural reinforcing experiments, the material is suitable for reinforcing the murals ofhumid burial chambers, and particularly well protects mural efflorescent and flaking of the murals. Compared with the prior art, the preparing process of the nanometer calcium hydroxide material is very simple, the time is saved, the preparation is controllable, and the cost is low. Besides, heating is not needed, preparation is conducted at the normal temperature, and energy consumption is low.

The invention discloses a biochar-supported magnetic substance composite adsorption material, and a preparation method and application method thereof, and belongs to the field of water treatment. The biochar-supported magnetic substance composite adsorption material is prepared by the following steps: mixing and uniformly grinding a biomass, a cobalt salt and a nickel salt to obtain a mixture, calcining the obtained mixture under the protection of inert gas, and performing cooling. The preparation scheme requires few steps, is environment-friendly, and has broad industrial production prospect, and the biochar-supported magnetic substance composite adsorption material prepared by the preparation method has a good adsorption effect.

The invention discloses a method for synthesizing diarylamine by optical / nickel concerted catalysis. According to the method, a ligand does not need to be added, and simple and cheap nickel salt is directly used as a metal catalyst to cooperate with a photosensitizer to catalyze arylamine and aryl bromide to generate cross-coupling. The method has the following advantages: (1) the use amount of BODIPY type organic photocatalyst is low, and the BODIPY type organic photocatalyst has a better catalysis effect in comparison with metal iridium and ruthenium photocatalysts reported in the literature; (2) the BODIPY type organic photocatalyst is easy for synthesis; (3) the use amount of nickel salt is few, and the ligand does not need to be added; and (4) the reaction conditions are mild, and theyield of most coupling products is higher than 90%. According to the method disclosed by the invention, high temperature and high pressure equipment is not needed, temperature change scope is small,experimental procedure is simple and easy to operate, and the method has a relatively high application value and industrial popularization potential.

The invention discloses a nickel cobaltate / titanium nitride array electrode material, which has a three-dimensional ordered multi-level pore structure, and the open macropores provide more active sites and transport spaces for the adsorption and transport of electrolyte ions in electrode reactions. , high conductivity titanium nitride provides a fast electron transport channel for nickel cobaltate, which effectively solves the defects of electrode material electrolyte ions and electrons that are difficult to transport quickly, resulting in poor rate performance and low energy storage efficiency. The mesoporous structure of the pore wall effectively increases the specific surface area of ​​the material and provides more active sites for the reaction, thereby improving the electrochemical energy storage performance. And it can be directly used as a new energy storage electrode material, which has high practical value and industrial production potential; the preparation process of the electrode material is reliable and easy, and has a good industrial production prospect.