The invention relates to anti-stress and puffed mixed feed for ctenopharyngodon idellus and a production method for the feed. The mixed feed includes the following raw materials in mass percentage: 0-8% of meat and bone meal, 2-5% of broad bean albumen powder, 8-18% of soybean meal, 20-30% of rapeseed dregs, 10-15% of cottonseed meal, 10-20% of wheat, 10-20% of tapioca flour, 5-8% of rice bran, 2-4% of soya-bean oil, 0.2-0.4% of 50% choline chloride, 0.9-1.5% of monocalcium phosphate, 1-2% of vitamin premix, 1-2% of mineral premix, 1-2% of zeolite powder, 0.02-0.1% of GSH, 0.01-0.08% curcumin, 0.01-0.03% of tea polyphenol, 0.05-0.1% of taurine, 0.005-0.01% of rheum emodin, 0.01-0.02% of L-carnitine, and 0.02-0.03% of complex enzyme preparation. The anti-stress and puffed mixed feed improves the digestibility and deposition of feeding ctenopharyngodon idellus to nutrient substances of the feed, improves the immune, antioxidant and anti-stress ability of fish body and promotes growing of ctenopharyngodon idellus.