68 results about "Trans-anethole" patented technology

The invention provides an isolation method for high purity anethole. Anise oil is used as a raw material, and a product of high purity anethole is produced after the steps of refrigeration, fragmentation, centrifugation and rectification are carried out. According to the invention, crystallization separating and rectification separating are combined, anethole with a high purity of no less than 99.6% is produced, and no solvent is needed for rinsing of crystals, which enables residual of solvents to be avoided, production procedures to be reduced and production cost to be lowered down.

The invention includes a dentifrice composition that comprises a zinc ion source, a polyphosphate ion source, an anethole, and a silica. The silica has a mean particle size of about 5 to about 12 microns, an Einlehner hardness of about 1 to about 20, and an oil absorption of about 40 to less than about 100 cc / 100 g. The composition contains zinc ions and polyphosphate ions in a weight ratio of about 0.1:1 to about 10:1 and has a RDA value of about 100 to about 200 and a PCR value of about 75 to about 110. Related methods are also included.

The invention discloses a synthetic method of anethole. Anisole and propionyl chloride serve as starting raw materials, are subjected to a friedel-crafts acylation reaction, then are restored through sodium borohydride, and then are catalyzed and dehydrated through organic acid and acid inorganic salt, and finally the anethole is manufactured through rectification. Side reaction is low through the adoption of acylation and reduction, a middle body is not needed to be purified and can be directly put into the next reaction, purification loss and purification cost of the middle body are reduced, yield coefficient is improved, and energy consumption is reduced. A chemical reduction method is utilized to replace a catalytic hydrogenation method, selectivity is high, response speed is fast, side reactions are small in number, and reduction yield coefficient can reach above 98%. Double catalysts are adopted to carry out ordinary pressure low temperature dehydration in dissolvent with a low boiling point, and compared with a negative pressure continuous dehydration method, dehydration time can be shortened by 90%, and the energy consumption is greatly reduced. The total yield coefficient of the method can reach 75%. A product quality index is higher than that of a natural product standard.

The invention discloses a method for purifying trans-anethole. In the method, star anise oil is purified mainly by two steps of coupling freezing crystallization and molecular distillation so as to obtain the trans-anethole. The method comprises the following steps of: freezing the star anise oil at a low temperature, crushing the frozen product, performing separation of a crystal and residue liquid on the crushed frozen product by filtration, high-speed centrifugation or pressure filtration, melting the crystal, and performing molecular distillation on the liquid obtained by melting to obtain high-purity anethole. The method has the advantages of no need of solvent, mild operating conditions, low cost, low energy consumption, high purity, simple process and the like.

The invention discloses a method for preparing methoxyphenylacetic acid by natural anethole; the natural anethole is taken as a raw material and generated into the anisicaldehyde by oxidation reaction, then anisic mandelic acid (salt) is generated by the insertion reaction of carbine; finally the methoxyphenylacetic acid is obtained by reduction. The method has the advantages of reproducible raw material, simple operation and high yield, etc.; furthermore, the method can prepare the methoxyphenylacetic acid which can replace the source of petrochemical industry.

The invention relates to a botanical essential oil for the control of plant pathogenic fungus and a preparation method thereof. The essential oil of the invention is extracted from star aniseseen fruits and contains 29 main ingredients through gas chromatography-mass spectrometry analysis, wherein, trans-anethole accounts for 83.483 percent. The invention first confirms that the trans-anethole is the main antibacterial active ingredient in the essential oil from the star aniseseen as well as the essential oil from the star aniseseen and the trans-anethole thereof has significant inhibition activity for a plurality of plant pathogenic fungus such as early blight of tomato, stem end rot of mango, corn leaf blight, wheat scab, cucumber fusarium wilt, tomato fusarium wilt, cotton fusarium wilt, rice blast fungus, pythium aphani-dermatum, wheat sheath blight, rice sheath blight, etc. and can control plant diseases.

The invention discloses a preparation method of anisic aldehyde and aims to provide a novel preparation method of anisic aldehyde in order to reduce the production cost of the anisic aldehyde and the environment pollution. The method comprises the following steps: isomerizing; carrying out refrigerated centrifugation; oxidizing; centrifuging; washing; and neutralizing. Estragole is subjected to steps such as isomerization, centrifugation and oxidization in the presence of a catalyst so that electrons in estragole molecules are rearranged, and foreign matters generate required anethole. The anethole is subjected to oxidization reaction under an acidic condition of manganese dioxide and transformed from ketone to aldehyde so that anisic aldehyde is obtained finally. According to the invention, the estragole is used as the raw material, the purification content of the estragole for preparing the anisic aldehyde can be up to over 97% and is about 13% higher than that of the traditional process. The preparation method is capable of remarkably increasing the yield of the anisic aldehyde and meeting the requirement for large-scale industrial production, easier to purify as well as little in equipment corrosion and environment pollution.

The invention discloses a preparation method for (Z)-3'-hydroxyl-3,4,4',5-tetramethoxyl diphenyl ethylene. A diphenyl ethylene framework structure is built by the Perkin reaction method, and natural aniseed fat-soluble components and propenyl anisole (anethole) are taken as raw materials, and oxidized to obtain anisaldehyde; dichlorocarbene insertion reaction is carried out on the anisaldehyde to obtain p-methoxyl-mandelic acid which is reduced to obtain methoxyl-phenylacetic acid, the methoxyl-phenylacetic acid is brominized to obtain 3-bromo-4-methoxyl-phenylacetic acid. The compound and the natural 3,4,5-trimethoxybenzaldehyde (nutgall extract derivative) carry out Perkin reaction to build a cis-form diphenyl ethylene framework which is further converted and decarboxylated by functional groups to obtain the (Z)-3'-hydroxyl-3,4,4',5-tetramethoxyl diphenyl ethylene. The raw materials of the invention are reproducible natural resources-anethole which are rich in China and 3,4,5-trimethoxybenzaldehyde, and replace non-renewable petrochemical materials which are used by the prior art and become less and less so that the method has the advantages of good sustainable development capability as well as remarkable economic, environmental and ecological benefits.

The invention provides a method for quantitatively detecting glycerol triacetate for tobacco. One substance or two substances in trans-anethole and propylene carbonate is / are used as internal standardsubstances to prepare extraction, and quantitative analysis is carried out on the extraction by an internal standard method. In the preparation process, the detected components and the internal standard substances are mixed together to be injected into a chromatographic column, and the changes of injection volume can not influence quantitative results. The mass percentage content of the detectedcomponents in the samples of the glycerol triacetate for tobacco can be detected more accurately, and monoacetin and glycerol diacetate can be distinguished.

The invention discloses a method for preparing anisaldehyde. The method comprises the following steps: (1) mixing anethole, organic solvents and water to obtain reaction materials; adding the reaction materials into a bubble reaction tower and introducing mixed gas of ozone and oxygen to carry out ozonization reaction; continuing introducing oxygen to expel redundant ozone after the ozonization reaction is over to obtain ozonization reaction liquid; and (2) heating anhydrous sodium sulfite solution to 60-80 DEG C and dropwise adding the ozonization reaction liquid to carry out reduction reaction; continuing reacting for 30-60min after dropwise adding the ozonization reaction liquid, cooling and standing the reactant and dividing the liquid to obtain the coarse anisaldehyde; and removing the organic solvents by distillation to obtain the anisaldehyde product. The method avoids a little side reaction in the process of ozonization, lowers the equipment and production cost, solves the keyproblems confronted by industrialized production, such as equipment corrosion due to presence of acetic acid, heavy environmental pollution and the like, and opens up a way for large-scale industrialized production.

The present invention relates to a process for preparing arylpropenes, especially 1-methoxy-4-(1-propenyl)benzene (anethole), by means of thermolysis of the corresponding 1,1-diarylpropanes.

The invention discloses an anise oil ice block crusher which comprises a feeding platform, a feed opening, a roller, a discharge opening, a cover, a feeding inclined bucket, a bracket and a stay bar, wherein the feeding platform is connected with the feed opening; the roller is arranged below the feed opening and is connected with a motor; and the discharge opening is formed below the roller. The anise oil ice block crusher has the characteristics of high speed for crushing an anethole ice block, uniformity in particle, small size of particles and the like; other anise oil components attached to an anethole crystal are easily separated during centrifugal separation; and the anise oil ice block crusher is suitable for crushing a frozen cylinder separated from the anise oil.

The invention discloses a preparation method of anisic acid, which comprises the following steps: taking a right amount of crude sulfate turpentine, and fractionating to obtain crush anethole; carrying out crystallizing separation on the anethole to obtain the high-purity anethole; adding the high-purity anethole and a NaHSO3 solution into a reaction kettle, and introducing ozone to perform oxidation for 110 minutes, thereby obtaining an anisic aldehyde sodium sulfite addition product A; simultaneously and slowly adding a sodium hydroxide solution and oxydol into A, stirring to react for 5.0-9.0 hours while keeping at 65-85 DEG C to obtain a reaction product B; and after the reaction is finished, adding a HCl solution into B to regulate the pH value to 1-3, and filtering to obtain the anisic acid. The method has the advantages of high yield and high purity and does not use any organic solvent in the separation process, so the product has no toxic or harmful solvent residue and can be used in the industries of medicine, food and cosmetics; the method has the characteristics of mild reaction conditions, simple purification and refinement and high product purity, and is simple to operate; and by using the ozone and oxydol as oxidizers, the reaction product is water, so the oxidizers are green and environment-friendly.

The invention discloses novel mouth wash, which is prepared from an organosilicon quaternary ammonium salt and water, wherein a chemical formula of the organosilicon quaternary ammonium salt is (C2H5O)2SiCH3(CH2)3N<+>(CH3)2C18H37Cl<->. The invention also discloses a preparation method of the novel moth wash. The preparation method comprises the following steps of S1, raising a temperature of waterto 80 to 90 DEG C, carrying out heat preservation for 12 to 30 minutes, lowering the temperature to normal temperature, then adding sorbitol, glycerol, a sweetener and allantoin, and agitating untilcomplete dissolution, so as to obtain a phase A; S2, mixing the organosilicon quaternary ammonium salt, peppermint oil, anethole oil, menthol and WS-3, and then agitating for 15 to 30 minutes, so as to obtain a phase B; S3, mixing the phase A in the step S1 and the phase B in the step S2, and agitating until transparency, so as to obtain the novel mouth wash. The mouth wash provided by the invention has favorable mouthfeel, has no irritation to a human body while enhancing cleaning and bacteriostatic effects, and further has no toxic and side effects on the human body.

The invention relates to a quality control method for volatile components of Shenbao tablets. The invention discloses a quality control method. The method comprises the step of measuring the contentsof volatile components, namely trans-anethole and ligustilide, in the Shenbao tablet. The method comprises the following steps: (1) testing chromatographic conditions and system applicability; (2) preparation of a reference substance solution: preparing a proper amount of trans-anethole reference substance, and adding an extraction solvent to prepare the reference substance solution; (3) preparation of a test solution: crushing the Shenbao tablets, adding the extraction solvent, carrying out ultrasonic treatment, filtering the liquid, and collecting a subsequent filtrate; and (4) determination: precisely sucking the reference substance solution and the test solution respectively, injecting into a liquid chromatograph, and determining the results. The content determination method established by the invention provides a reliable way for quality control of volatile components in the Shenbao tablets, and can control the product quality more comprehensively.

The invention discloses an extraction method of linalool. The extraction method comprises the following steps: (1) extracting fennel oil from fruits and leaves of aniseed; (2) rectifying to separate a front cut fraction (30 percent of estragole) generated in the process of preparing anethole from the fennel oil, and obtaining 80 percent of estragole and about 12 percent of terpilenol azeotrope; and (3) placing the azeotrope obtained in the step (2) into a high-performance rectifying tower, intermittently feeding the materials, efficiently rectifying separating, adjusting a reflux ratio and a vacuum degree at three kettle temperature stages of 80 DEG C, 95 DEG C and 110 DEG C, placing the obtained head oil into a high-performance separation tower, controlling the kettle temperature at 50 to 60 DEG C at the low pressure less than or equal to 100Pa, collecting a fraction of 45 to 48 DEG C, adjusting the temperature to 70 to 110 DEG C, collecting the fraction of 65 to 84 DEG C, adjusting the temperature to 110 to 125 DEG C, and collecting tail oil. The front cut fraction generated in the anethole extraction process is used as the raw material, so that the price is low; and the processing is carried out on the basis of the existing equipment, so that the operation is simple, the equipment depreciation is reduced, and the enterprise benefit is increased. No additive is adopted, so that the extraction method of the linalool is natural and environment-friendly.

The invention discloses a method for detecting the content of trans-anethole in fennel. The method includes the steps: a contrast solution is prepared, specifically, trans-anethole reference substanceis taken and added with ethyl acetate to prepare the contrast solution; a tested solution is prepared, specifically, a fennel sample is taken and added with the ethyl acetate, the mixture is weightedto obtain a weight A, after ultrasonic treatment and chilling, the mixture is weighted again to obtain a weight B, the ethyl acetate is used for making up the weight lost from the A to the B, a subsequent filtrate is taken after shaking up and filtering, and the tested solution is obtained; and determination is conducted, specifically, the contrast solution and the tested solution are taken correspondingly and injected into a gas chromatograph for determination, and the trans-anethole content can be detected. According to the detection method, the degree of separation is high, matrix interference can be resisted, sensitivity is high, stability is high, and the accuracy is high.

An attractant composition is disclosed for adult noctuid or other lepidopteran species, which comprises a mixture of about 10-45% w / w phenylacetaldehyde, 5-30% w / w anethole, 0-30% w / w 4-methoxy benzyl alcohol, and 0-30% w / w 2-methoxy benzyl alcohol.

The invention relates to a prevention and treatment method for peach fruit moths. The prevention and treatment method is characterized by comprising the following steps of: (1) forming contact solution by trans-anethole and alcohol (having a volume concentration of 98%) in a volume ratio of 1: 100, wherein the contact solution is used for killing the moths by means of contact before the bags of fruits are released in June, July and August; and (2) forming fumigation solution by the trans-anethole and the alcohol (having a volume concentration of 98%) in a volume ratio of 1: 50, wherein the fumigation solution is used for killing the moths by means of fumigation after the bags of fruits are released and before the fruits are taken off from trees. The prevention and treatment method disclosed by the invention is low in toxicity, less in residue, strong in selectivity, and safe to natural enemy, can not destroy ecological environment, can avoid the problem of the resistance generated by diseases and insect pests; and most crucially, human security is highly guaranteed on the premise of no reduction on killing and treatment effects.

The present invention provides a flavour composition which is a mixture of flavour materials, characterised in that the flavour composition comprises at least 8% by weight of the total weight of the flavour composition of ingredients selected from the following groups of flavour materials: (a) at least 0.5% by weight of the flavour composition of one or more of the following: a peppermint oil comprising 1-isopropylidene-4-methyl-2-cyclohexanone in an amount from 1% to 4% by weight, 5-methyl-2-(1-methylethyl)-1-cyclohexanone in an amount from 8% to 13% by weight and less than 0.5% by weight of eucalyptol; a spearmint oil comprising less than 70% by weight of carvone and at least 14% by weight of limonene; or mixtures thereof; and (b) at least 0.5% by weight of the flavour composition of two or more of the following: decanol, octanal, allyl hexanoate, anethole, aniseed rectified, basil oil, benzyl butyrate, camomile oil, cinnamic aldehyde, cis-3-hexenyl acetate, citral natural, citronella ceylon, ethyl heptanoate, eugenol, fennel sweet, geranyl acetate, ionone alpha, lime, orange flavour, para cresyl methyl ether, pinene alpha. These materials have been identified as capable of inhibiting the production of odoriferous volatile sulphur compounds by microorganisms present in the oral cavity, and so to possess hitherto unappreciated oral malodour reducing properties.

The invention provides an identification method of a fennel producing area. The method comprises the following steps: (1) taking a to-be-detected fennel sample, extracting volatile oil, and respectively determining the content of each of estragole, fennel anethole, (R)-(+)-limonene, an antioxidant 2246, L(-)-fenchone and terpinene in the volatile oil; and (2) bring the content of each of the estragole, the fennel anethole, the (R)-(+)-limonene, the antioxidant 2246, the L(-)-fenchone and the terpinene into formulas of PC1 = 0.03 x (R)-(+)-limonene - 0.90 x estragole - 0.21 x fennel anethole -0.09 x antioxidant 2246 - 0.27 x L(-)-fenchone - 0.25 x terpinene, and PC2 = 0.07 x estragole - 0.66 x (R)-(+)-limonene - 0.50 x fennel anethole - 0.52 x antioxidant 2246 + 0.16 x L(-)-fenchone + 0 .12 x tertenene, and then carrying out determination according to numerical values of PC1 and PC2. Through the identification method of the invention, quality difference of 10 types of fennel of different producing areas is successfully identified.

The invention discloses a mutant and a mutant strain of trans-anethole oxygenase. Compared with an amino acid sequence of a wild type trans-anethole oxygenase, 185-bit amino acid Glu of the mutant ofthe trans-anethole oxygenase becomes Asp, and the amino acid sequence of the mutant of the trans-anethole oxygenase is as shown in SEQ ID No 1. The conversion rates of synthesis for anisaldehyde, veratraldehyde, heliotropin, and vanillin are 1.91, 2.08, 1.33 and 1.92 times of the original strain, respectively. 5F4 shows good application potential in synthesis of aromatic aldehyde flavor by a biological method; at the same time, the adaptability of the pH during the catalysis of 5F4 is wider, which is more suitable for industrial production applications and can reduce costs and increase production efficiency.

The invention discloses a new method for purifying high-purity transacomhole. Fennel oil is firstly rectified in vacuum at the pressure of less than 200Pa and kettle temperature of 100-130DEG C; and then, the obtained fennel oil is frozen, crystallized, smashed and separated to obtain anethole of which the purity is 99.7%. The technology has the advantages of short period, low energy consumption and high product purity, and meanwhile, the pure natural fennel taste of the product can be furthest kept.

An anise flavored liquid medication. The liquid medication contains phenylephrine and an anethole analog that is substantially free of aldehyde groups. In one example, the anethole analog can be 1-methoxy-4-n-propylbenzene.

The invention discloses a trans-anethole oxygenase mutant, and a mutant strain. When the amino acid sequence of the trans-anethole oxygenase mutant is compared with the amino acid sequence of wild-type trans-anethole oxygenase, it is found that the 319th site amino acid proline is replaced by serine, and the amino acid sequence of the trans-anethole oxygenase mutant is represented by SEQ ID NO 1.According to a construction method, error-prone PCR is adopted, random mutation of trans-anethole oxygenase is realized, introduction into E.Coil BL21(DE3) is carried out, and the mutant strain 4C7 isobtained through screening. The conversion rates of the trans-anethole oxygenase mutant on anisaldehyde and veratraldehyde are 2.05 and 2.38 times of those of an original bacterial strain; the trans-anethole oxygenase mutant is more suitable for industrialized production; production cost is reduced; and production efficiency is increased obviously.

The invention relates to a method for preparing trans-anethole-albumin nanoparticles with indocyanine green fluorescence tracer. The method comprises the following steps: selecting albumin as a raw material, adjusting the ratio of encapsulated indocyanine green fluorescent dye to trans-anethole drug and solvent, and fully controlling particle size to prepare nanoparticles with size of 20-50 nm; encapsulating the indocyanine green fluorescent dye and trans-anethole simultaneously in albumin nanoparticles, so that the trans-anethole-albumin nanoparticles have therapeutic and imaging functions. The drug release in vitro is determined by high performance liquid chromatography. In phosphate buffer solution, the release rate of sustained release for 96 h is only 31%, and the sustained-released effect is significant. The synthesis process provided by the invention is simple, non-toxic and fast, and has a large yield and significant reduction in the particle size of the particles compared withthe prior art. In an in vitro sustained-release test, the trans-anisole-albumin nanoparticles with indocyanine green fluorescence tracer have good sustained-released effect, and the release rate is only 31% after 96 h, so the nanoparticles have sustained-released effect.

The invention relates to a use of 3h-1,2-dithiole-3-thione, anethole dithiolethione, sulforaphane, phenethyl isothiocyanate, 6-methyl-sulphinyl)hexyl isothiocyanate and allyl isothiocyanate and derivatives thereof for treating whitening of the hair and combination thereof. At least one compound selected from among 3H-1,2-dithiole-3-thione, anethole dithiolethione, sulforaphane, phenethyl isothiocyanate, 6-(methylsulfinyl)hexyl isothiocyanate and allyl isothiocyanate and derivatives and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and / or promote hair regrowth, are useful for preventing and / or limiting and / or stopping the development of canities.

The invention relates to a combined drug of anethole and fenofibrate drugs. A composition formed by the anethole and fenofibrate drugs or a carrier which can be accepted in pharmacy is applied to treating fatty liver diseases. When the composition is used for treating the fatty liver, not only the synergy can be achieved, but also the toxicity of the two drugs when singly used can be decreased. As proved by the pharmacodynamic experiments, the composition of the anethole and fenofibrate drugs has good therapeutic effect on fatty liver animal models, is obviously superior to the single use of the anethole and fenofibrate drugs, and is hopeful to be a novel drug for treating the fatty liver.