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Combined drug of anethole and fenofibrate drugs

A fibrate, bile and vitamin technology, applied in the field of medicine, can solve problems such as unpredictable

Active Publication Date: 2010-06-23
CHENGDU DIAO JIUHONG PHARMA FAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, it is difficult for those skilled in the art to predict whether the two drugs can be used in combination to exert synergistic effects or reduce toxicity.

Method used

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  • Combined drug of anethole and fenofibrate drugs
  • Combined drug of anethole and fenofibrate drugs
  • Combined drug of anethole and fenofibrate drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 medicine of the present invention

[0024] Take 26g of the raw material medicine of anetellitate, 100g of the raw material medicine of fenofibrate, and 400g of microcrystalline cellulose, after fully mixing, 1000 capsules of No. 1 can be packed.

Embodiment 2

[0025] The preparation of embodiment 2 medicines of the present invention

[0026] Take 26g of anetis trisulfide raw material drug, 100g of bezafibrate raw material drug, and 80g of lactose, after mixing evenly, add 10% starch slurry made of 110g of starch, and spray granulate. Then add 10 g of magnesium stearate and 10 g of PVP, mix uniformly, and then compress into 1000 tablets.

Embodiment 3

[0028] The common preparations described in Example 1 or Example 2 are prepared in combination with anetthio and fibrates, and the specific dosage is shown in the following table: (unit: g)

[0029]

[0030] Further prove the beneficial effect of the present invention by pharmacodynamic test below.

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PUM

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Abstract

The invention relates to a combined drug of anethole and fenofibrate drugs. A composition formed by the anethole and fenofibrate drugs or a carrier which can be accepted in pharmacy is applied to treating fatty liver diseases. When the composition is used for treating the fatty liver, not only the synergy can be achieved, but also the toxicity of the two drugs when singly used can be decreased. As proved by the pharmacodynamic experiments, the composition of the anethole and fenofibrate drugs has good therapeutic effect on fatty liver animal models, is obviously superior to the single use of the anethole and fenofibrate drugs, and is hopeful to be a novel drug for treating the fatty liver.

Description

technical field [0001] The invention relates to a new application of a combination of cholevitamin and lipid-lowering drugs. It belongs to the field of medical technology. technical background [0002] Cholesterol, also known as fennel trisulfide, is a choleretic drug commonly used in clinical practice, and it also has a good curative effect on acute and chronic hepatitis. Fibrates are a class of lipid-lowering drugs that are widely used at present. They have a strong and obvious effect on lowering triglycerides. Under normal doses, triglycerides can be reduced by 20-60%. Mixed hyperlipidemia with elevated triesters is very effective. Fenofibrate, bezafibrate, gemfibrozil, and ciprofibrate, which are commonly used in clinical practice, have PPARalpha (peroxisome proliferator-activated receptor Body) agonist, can effectively reduce triglycerides, cholesterol, and can also increase the level of HDL (high-density lipoprotein) in plasma. However, the disadvantage of fibrates ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/385A61K45/00A61K31/215A61K31/192A61P1/16
Inventor 黄振岑国栋
Owner CHENGDU DIAO JIUHONG PHARMA FAB
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