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Use of 3h-1,2-dithiole-3-thione, anethole dithiolethione, sulphoraphane, phenethyl isothiocyanate, 6-(methylsulphinyl)hexyl isothiocyanate and allyl isothiocyanate for the treatment of canities

A technology of heterocyclopentadienethione and thiolene, applied in the application field of several dithiolanthione and isothiocyanate compounds in the treatment of gray hair , capable of addressing the lack of identification of the cause of specific and progressive depletion of melanocytes and melanocyte precursors

Inactive Publication Date: 2008-07-30
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To date, the cause of the specific and gradual depletion of melanocytes and melanocyte precursors in the hair follicle remains undetermined

Method used

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  • Use of 3h-1,2-dithiole-3-thione, anethole dithiolethione, sulphoraphane, phenethyl isothiocyanate, 6-(methylsulphinyl)hexyl isothiocyanate and allyl isothiocyanate for the treatment of canities
  • Use of 3h-1,2-dithiole-3-thione, anethole dithiolethione, sulphoraphane, phenethyl isothiocyanate, 6-(methylsulphinyl)hexyl isothiocyanate and allyl isothiocyanate for the treatment of canities
  • Use of 3h-1,2-dithiole-3-thione, anethole dithiolethione, sulphoraphane, phenethyl isothiocyanate, 6-(methylsulphinyl)hexyl isothiocyanate and allyl isothiocyanate for the treatment of canities

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Example 1 - Determination of the activity of useful compounds of the present invention

[0084] 1-A-1. Determination of the passage of H in cultured normal human melanocytes (NHM) 2 O 2 stress-induced activity Oxygen species (ROS) scheme

[0085] Normal human melanocytes (NHMs) at a density of 4×10 4 cells / cm 2 inoculated on the DO. In D1, the medium was replaced with 10 μM 6-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, bis[methyl acetate] in PBS (H 2 DCFDA, C2938, Molecular Probes). 20 minutes later, H 2 DCFDA solution was replaced with culture medium. After joining H 2 o 2 The NHMs were allowed to stand for 30 min before solution (250 μM). Fluorescence was measured after 15 minutes in a fluoroscope (activation: 485 nm, emission: 538 nm).

[0086] The use of research compounds depends on their nature (concentration, pre-incubation time). N-acetylcysteine ​​(A9165-Sigma) was used as a control molecule. At 37°C, melanocytes were pretreate...

Embodiment 2

[0098] Example 2 - Composition

[0099] -shampoo

[0100] 3H-1,2-Dithiole-3-thione 0.5g

[0101] Propylene Glycol 20g

[0102] 95° ethanol 30g

[0103] Appropriate amount of water to 100g

[0104] The shampoo is used daily on the treated area, preferably on the entire scalp for at least 10 days, preferably for 1 to 2 months. A reduction in the appearance of white or gray hair followed by recoloration of the gray hair is observed.

[0105] treatment shampoo

[0106] Lavender sulfur 1.5g

[0107] Polyglyceryl-3 hydroxyaryl ether 26g

[0108] Hydroxypropylcellulose called KLUCELL G by Hercules 2g

[0109] Appropriate amount of preservatives

[0110] 95° ethanol 50g

[0111] Appropriate amount of water to 100g

[0112] The shampoo was used in each wash with a contact time of about 1 minute. Prolonged use for about two months resulted in a reduction in gray hair and a gradual recoloration of the gray hair.

[0113] This shampoo can also be used prophylactically t...

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Abstract

The invention relates to a use of 3h-1,2-dithiole-3-thione, anethole dithiolethione, sulforaphane, phenethyl isothiocyanate, 6-methyl-sulphinyl)hexyl isothiocyanate and allyl isothiocyanate and derivatives thereof for treating whitening of the hair and combination thereof. At least one compound selected from among 3H-1,2-dithiole-3-thione, anethole dithiolethione, sulforaphane, phenethyl isothiocyanate, 6-(methylsulfinyl)hexyl isothiocyanate and allyl isothiocyanate and derivatives and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and / or promote hair regrowth, are useful for preventing and / or limiting and / or stopping the development of canities.

Description

technical field [0001] The present invention relates to 3H-1,2-dithiol-3-thione (D3T), anethole dithiol-3-thione (ADT), radish sulfur, benzene isothiocyanate Cosmetic use of ethyl esters, 6-(methylsulfinyl)hexyl isothiocyanate and allyl isothiocyanate, derivatives and mixtures thereof, in the treatment of gray hair. Background technique [0002] A hair follicle is a tubular depression in the epidermis that extends deep into the dermis. The lower part or hair bulb itself contains a depression in which the dermal papilla is found. The lower part of the hair bulb is an area of ​​cellular proliferation where the precursors of the hair-forming keratinocytes are found. The ascending cells arising from these precursors progressively keratinize the upper part of the hair bulb, and this collection of keratinocytes forms the hair shaft. [0003] The color of hair and body hair depends in particular on the different amounts and ratios of the presence of two groups of melanin pigment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/46A61K8/49A61K31/385A61K31/21A61Q5/00A61P17/14
CPCA61K8/4986A61K8/46A61K8/11A61K2800/413A61Q5/10A61K2800/412A61P17/00A61P17/14B82B3/00B82Y5/00G01N33/48G01N33/50
Inventor S·康莫
Owner LOREAL SA
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