33 results about "Staphylococcus salivarius" patented technology

This invention relates to methods for inhibiting growth of anaerobic bacteria, particularly halitosis causing bacteria. The methods use BLIS-producing Streptococcus salivarius strains, extracts thereof, and compositions comprising same in the prevention or treatment of halitosis.

A probiotic formulation includes the following: lactobacillus acidophilus comprising 15.0% to 40.0% per mass of the probiotic formulation; lactobacillus reuteri comprising 5.0% to 20.0% per mass of the probiotic formulation; lactobacillus salivarius comprising 5.0% to 20.0% per mass of the probiotic formulation; lactobacillus paracasei comprising 5.0% to 20.0% per mass of the probiotic formulation; streptococcus thermophiles comprising 5.0% to 20.0% per mass of the probiotic formulation; streptococcus salivarius BLIS K-12 comprising 5.0% to 30.0% per mass of the probiotic formulation; streptococcus salivarius BLIS M-18 comprising 5.0% to 30.0% per mass of the probiotic formulation; zinc oxide comprising 0.2% to 5.0% per mass of the probiotic formulation; hydroxyapatite comprising 0.1% to 25.0% per mass of the probiotic formulation; and dicalcium phosphate comprising 0.1% to 5.0% per mass of the probiotic formulation. The probiotic formulation may be formed into a lozenge or a gum.

The invention discloses a composition, application thereof and an oral preparation capable of improving the oral health. According to the composition, by adding 1-20 parts of lactobacillus rhamnosus R11, 1-20 parts of streptococcus salivarius blis K12 and 1-20 parts of lactobacillus reuteri HA188 (in parts by weight), the effect of probiotics on the improvement of the oral health is obviously improved; by further adding one or more of lactobacillus helveticus Lafti L10, saccharomyces cerevisiae boulardii, folic acid compounds, coenzyme Q10, vitamin C, fructo-oligose, xylooligosaccharide and galactooligosaccharide, the effect of the composition on the improvement of the oral health can be further improved; and an unexpected discovery shows that by adjusting the addition weight ratio of streptococcus salivarius blis K12 to lactobacillus reuteri HA188, the light degradation rate of the folic acid compounds in the composition can be remarkably decreased. The composition prepared by virtueof an equivalent gradient premixing method can be used for preparing the oral preparation capable of improving the oral health.

The invention provides an application of streptococcus salivarius K12 in preparing a medicament for preventing and / or treating autoimmune diseases, and belongs to the technical field of treatment of autoimmune diseases. Preventive intervention of the streptococcus salivarius K12 can inhibit occurrence and development of experimental arthritis, so that the incidence of the experimental arthritis isreduced by 30-70% and the synovial tissue of a joint can be prevented from infiltration and erosion of inflammatory cells; in addition, streptococcus salivarius also has therapeutic effects on the experimental arthritis. The streptococcus salivarius K12 can significantly down-regulate the ratio of Tfh cells, GCB cells, DC cells and Neu cells, inhibit the expression of proinflammatory cytokine IL-6, and promote the secretion of anti-inflammatory cytokine IL-10. The streptococcus salivarius can promote the immune steady-state reconstruction by inhibiting the immune response and provides a potential target for the treatment of rheumatoid arthritis; can target and regulate abnormal immune cells, treat diseases from an upstream way, and regulate immune balance.

The invention provides the application of salivaricin in the preparation of medicines for preventing and / or treating autoimmune diseases, and belongs to the technical field of autoimmune diseases treatment. Streptococcus salivarius is an antimicrobial peptide synthesized and secreted by Streptococcus salivarius, which plays an important role in maintaining the local microecological balance of the mucosa. Salivaricin can significantly promote the secretion of anti-inflammatory cytokine IL-10, and inhibit the expression of pro-inflammatory cytokines IL-17, IL-21 and TNF-α. Simultaneously, salivaricin upregulates the proportion of anti-inflammatory regulatory T (Treg) cells, and downregulates the proportion of pro-inflammatory follicular helper T cells and helper T‑17 cells among immune cell subsets. Salivaricin can improve immune imbalance by inhibiting immune response, rebuild immune balance, and provide a new treatment method for autoimmune diseases such as rheumatoid arthritis.

The invention discloses a probiotic composition, which comprises Lactobacillus acidophilus, Streptococcus salivarius M18 and Streptococcus salivarius K12. The invention is beneficial to the regeneration of damaged alveolar bone, can inhibit the growth of periodontal pathogenic bacteria at the same time, can prevent and treat periodontitis to a certain extent, can effectively inhibit periodontal disease, and solve the problem of unhealthy teeth of modern people.

The invention discloses a preparation method of tremella fermented extract and its application in cosmetics. The method uses white fungus and water as raw materials to obtain the white fungus fermented extract through high-temperature fermentation, ultra-high-speed shear stirring, low-temperature fermentation, sterilization, and centrifugation; and at least one of Streptococcus salivarius subsp. thermophile; the low-temperature strain selected for the low-temperature fermentation is a strain obtained by mixing yeast and lactobacillus. The white fungus fermented extract prepared by the present invention can be used as a mask essence, and further made into a mask for water replenishment and moisturizing. The raw materials used in the present invention are all additives allowed in cosmetics, and Tremella itself (containing tremella polysaccharide) has the effect of replenishing water and moisturizing. Small in size, it is more conducive to the absorption and moisturizing of the human skin surface.

The invention provides a fermented crude extract of Streptococcus salivarius and its preparation method and application. The preparation method comprises the following steps: (1) inoculating Streptococcus salivarius CGMCC NO.13308 in M17 medium containing sucrose for fermentation , to obtain a fermented liquid, the gained fermented liquid is centrifuged to get the supernatant; (2) add ammonium sulfate to the supernatant obtained in step (1), and centrifugally collect the precipitate that separates out when the saturation of ammonium sulfate is 40~80%, and the The resulting precipitate was dissolved, dialyzed, and freeze-dried. The present invention adopts Streptococcus salivarius CGMCC NO.13308 strain for the first time to obtain fermented crude extract, the fermented crude extract of Streptococcus salivarius has inhibitory effect on Streptococcus mutans biofilm formation, discloses that Streptococcus salivarius CGMCC NO.13308 has fermentation The new use of generating inhibitors of Streptococcus mutans biofilm formation broadens the source of inhibitors of Streptococcus mutans biofilm formation.