222 results about "Lactobacillus salivarius" patented technology

The invention relates to a composite probiotics feed additive containing lactic acid bacteria. The composite probiotics feed additive is prepared by spraying, freezing, drying and compounding 40-60% of lactobacillus acidophilus, 15-20% of lactobacillus amylophilus, 5-10% of lactobacillus salivarius, 5-10% of streptococcus thermophilus, 5-10% of bacteroides thetaiotaomicron and 5-10% of glucose. All strains are separated from pig intestines chime. With the consideration of each part of an intestinal canal of animal, the lactic acid bacteria which produce lactic acid of the front section of the intestinal canal are combined with the bacteroides thetaiotaomicron which dissolve cellulose and polysaccharide of the rear section of the intestinal canal, the proportion among the bacteria is similar to the composition of corresponding bacteria in the intestinal canal of a healthy animal, so that the respective advantages can be developed well, the health of the animal is improved further, the feed digestibility is improved, and the production performance of the animal is improved.

Use of an association of lactobacilli for preparation of a pharmaceutical composition for treatment of vaginosis and vaginitis. Said bacteria association comprises the Lactobacillus brevis and Lactobacillus salivarius subs. salicinius species, possibly in combination with one or more species selected from Lactobacillus salivarius subs. salivarius, Lactobacillus jensenii, Lactobacillus catenaforme, Lactobacillus minutus and Lactobacillus gasseri.A pharmaceutical composition comprising said association of lactobacilli adapted for treatment of vaginosis and vaginitis.A method of treating vaginosis and vaginitis based on administration of said pharmaceutical composition.

The invention provides a probiotic composition to alleviate Salmonella infection in farm animals. The composition may comprise at least one of Lactobacillus murinus, Lactobacillus pentosus, Lactobacillus salivarius sub-species salivarius, and Pediococcus pentosaceus. The composition maybe formulated as an animal feedstuff, or as a pharmaceutical composition.

The invention discloses a biomarker capable of detecting diseases. The biomarker at least comprises one of the following microbes or the combination of the following microbes: Akkermansia muciniphila, Bacteroides fragilis, Clostridium bolteae, Clostridium hathewayi, Clostridium sp.HGF2, Clostridium symbiosum, Eubacterium limosum, Lactobacillus fermentum, Lactobacillus salivarius, Ruminococcus torques, Streptococcus anginosus, Streptococcus infantis, Bacteroides stercoris, Bacteroides uniformis, Bilophila wadsworthia and Clostridiales sp.SS3 / 4. The invention further discloses an application of the biomarker for determining inflammatory bowel diseases. The invention also discloses a method, a system and a kit for detecting the biomarker in a tested object. According to the invention, through the research on intestinal flora, and through the high-throughput genome sequencing, the biomarker with high relativity with the inflammatory bowel diseases is screened out, and then the biomarker is utilized for accurately and efficiently detecting and diagnosing the inflammatory bowel diseases, and further used for monitoring the treatment effect for the disease.

The invention discloses a mycotoxin degrading adsorbent, which contains bacillus subtilis, lactobacillus plantarum, lactobacillus acidophilus, leuconostoc lactis, lactobacillus delbrueckii, lactobacillus fermenti, lactobacillus salivarius, vitamin C, vitamin E, radix astragali, zinc methionine, potassium chloride, cassia bark, clove, oriental wormwood, folium artemisiae argyi, sweet wormwood, wild chrysanthemum flower, semen plantaginis, yeast cell wall and phytase. The mycotoxin degrading adsorbent disclosed by the invention has multiple effects including generation inhabitation, degradation and adsorption on various common mycotoxins, and can additionally boost immunities of pigs and promote excretion of toxic substances; the mycotoxin degrading adsorbent has excellent comprehensive performance and plays a remarkable role on productivities of piglets, and the mycotoxin degrading adsorbent can reduce disease rate, improve daily gain, increase feed digestibility and reduce feed conversion ratio. Moreover, the mycotoxin degrading adsorbent is low in dosage but effective and free from adsorption on drugs and other nutrient substances, and the adsorbent can be biologically degraded after being secreted and avoid pollutants; and the mycotoxin degrading adsorbent has good application value in breeding industry.

The invention relates to a making method of fermentation rice flour. Common whitening long-grain rice is adopted as a raw material, fermentation broth produced from natural fermentation in the making process of the fermentation rice flour is used as a fermentation stock solution, and mixed liquid containing Lactobacillus fermentium, lactobacillus salivarius, lactobacillus plantarum and yeast is utilized in the fermentation stock solution to formulate mixed fermentation liquid. The fermentation rice flour is prepared by soaking the common whitening long-grain rice with warm water, fermenting the soaked rice with the mixed fermentation liquid at constant temperature, and subjecting the fermented rice after constant-temperature fermentation to filtering, centrifuge draining, grinding and drying in sequence. The rice flour processed in the invention contains low cadmium, has a fragrant flavor, and can be used for processing products such as rice noodles, rice cakes with better quality.

The invention relates to probiotic solid beverage and a preparation method thereof. The probiotic solid beverage comprises the following raw materials in parts by weight: 24 to 70 parts of maltodextrin, 20 to 60 parts of inulin and 1 to 5 parts of probiotics, wherein the probiotics comprises lactobacillus salivarius, lactobacillus acidophilus, bacillus coagulans, lactobacillus rhamnosus, bifidobacterium bifidum, lactobacillus plantarum and bifidobacterium longum. The probiotic solid beverage provided by the invention has high living bacterium quantity and can reduce loss of the probiotics whenthe probiotics pass through the gastrointestinal tract and increase the survival rate; in addition, the probiotic solid beverage can promote intestinal colonization of the probiotics; moreover, through mutual promotion of the actions of various bacteria, the probiotic solid beverage can adjust intestines and stomach well, promote intestinal tract movement, relieve constipation and diarrhea, reduce serum cholesterol, reduce lactose intolerance, accumulate proteolytic enzyme, adjust nutrient absorption and adjust the immunologic function.

The invention belongs to the field of microbes, and concretely relates to a lactic acid bacterium with wide-spectrum bacteriostatic activity and application thereof. The lactic acid bacterium with wide-spectrum bacteriostatic activity is named lactobacillus salivarius GZPH2, is preserved at China Center for Type Culture Collection (CCTCC) since 27th, November, 2014, and has the preservation number of CCTCC M 2014598. The provided lactic acid bacterium lactobacillus salivarius GZPH2 has good bacteriostatic effect on multiple pathogenic bacteria of human and aquaculture bionts, and possesses the characteristics of not generating histamine, no hemolysis, acid resistance, cholate resistance and the like.

The invention discloses Lactobacillus salivarius and a freeze-dried preparation thereof and application of the freeze-dried preparation, and relates to an animal probiotic strain and a freeze-dried preparation thereof. The name of the Lactobacillus salivarius is Lactobacillus salivarius ZLS006; and the collection number of the Lactobacillus salivarius is CGMCC No. 5761. The invention also provides the freeze-dried preparation which is prepared from the Lactobacillus salivarius ZLS006. The test proves that the freeze-dried preparation can improve the conversion efficiency of feeds for swinery, increase the viable count of lactic acid bacteria in manure of the swinery, and reduce the content of Escherichia coli, and has the effect of improving the immunity of organisms.

The invention relates to a probiotic composition, and discloses a probiotic composition beneficial for a glycolipid metabolic function and a preparation and application of the composition. The probiotic composition comprises some of the following nine probiotics: bifidobacterium longum, bifidobacterium breve, lactobacillus gasseri, lactobacillus rhamnosus, lactobacillus salivarius, lactobacillus crispatus, lactobacillus plantarum, lactobacillus fermentum and lactobacillus casei. Different strains in the probiotic composition cooperate with each other, so that the probiotic composition has thefunction of adjusting glycolipid metabolism, and has certain effect on serum total cholesterol, triglycerides, insulin beta-cell functions and diabetes mellitus improvement.

The invention discloses a method for preparing L-lactic acid and a special bacteria agent thereof. The method comprises the steps: fermenting and culturing lactobacillus rhamnosus SMB-05 CGMCC N03122, lactobacillus salivarius SMB-06 CGMCC N03123, and lactobacillus paracasei SMB-07 CGMC N03124, and obtaining the L-lactic acid. The experiment result shows that the fermentation is carried out for 37 hours, the quantity of the total lactic acid in the fermentation liquor is 216 to 241g / L, the optical purity of the L-lactic acid is 98 percent to 99 percent and the fermentation production rate is 2.2 to 6.5g / L-h. By the mixed fermentation technology, the invention improves the production quantity and the production rate of the L-lactic acid, greatly reduces the cost of the L-lactic acid and has important industrial application value.

The invention relates to the technical field of health-care food, in particular to a probiotic composition as well as application and a product thereof. The probiotic composition comprises the following components in parts by weight: 2-6 parts of lactobacillus rhamnosus Rosell-11, 2-5 parts of lactobacillus helveticus Lafti L10 and 1-3 parts of lactobacillus salivarius HA-118. The acting principleof the probiotic composition is achieved by adjusting the dynamic balance of bacterial florae in an oral cavity; through a mechanism of competing with oral pathogenic bacteria, growth and adhesion ofthe pathogenic bacteria are inhibited, so that periodontitis and bad breath are alleviated; researches show that through cooperative use of the lactobacillus rhamnosus Rosell-11, the lactobacillus helveticus Lafti L10 and the lactobacillus salivarius HA-118, the probiotic composition has a significant synergetic effect.

The present invention provides a probiotics product comprising, as an effective component, lactic acid bacteria belonging to Lactobacillus salivarius possessing high adhesiveness to mucous membrane, a high proliferation ability and a high resistance to acids, a composition for preventing and / or treating digestive tract's diseases comprising the probiotics product as an effective component and a novel Lactobacillus salivarius strain possessing high adhesiveness to mucous membrane, a high proliferation ability and a high resistance to acids. The lactic acid bacteria and the probiotics product and the composition for preventing and / or treating digestive tract's diseases, which contain the lactic acid bacteria as an effective component, according to the present invention can sufficiently show their probiotics functions without being easily discharged from the digestive tract and urinogenital organs.

The invention discloses a lactobacillus salivarius for efficiently inhibiting avian pathogenic salmonella and an application of the lactobacillus salivarius. The lactobacillus salivarius is separated from healthy chicken flocks and is named lactobacillus salivarius SCL87 with the preservation number of CCTCC NO: M2015338. The strain has acid resistance, cholate resistance, trypsin resistance and good adhesion capacity. A supernatant secreted by the strain has the strong inhibition effect on the avian salmonella, and can effectively competitively inhibit growth of the avian salmonella, prevent and treat the avian salmonella and promote growth of birds. The strain can be applied to preparation of preparations for preventing infection of the avian salmonella or preparation of preparations for improving ecological balance of intestinal flora of the birds and promoting growth of the birds.

The invention relates to the technical field of food enzymes, and discloses a symbiotic microflora enzyme. The symbiotic microflora enzyme contains symbiotic microflora which has the effect of preventing, resisting and inhibiting helicobacter pylori. The symbiotic microflora contains main microflora and auxiliary microflora which aim at enhancing microflora effects and increasing the microflora number, wherein the main microflora comprises lactobacillus acidophilus, lactobacillus bulgaricus, lactobacillus plantarum, lactobacillus rhamnosus, Roy's lactobacillus, lactobacillus casei, lactobacillus gasseri, lactobacillus johnsonii, lactobacillus salivarius, lactobacillus brevis, lactic streptococci, bacillus subtilis, bifidobacterium bifidum, bifidobacterium adolescentis, bifidobacterium infantis, bifidobacterium breve and bifidobacterium longum. After the symbiotic microflora enzyme is drunk, the contained powerful and rich symbiotic microflora can naturally exist in the digestive system of the human body, obtains the living space advantage in the ecological environment, and achieves the effect of eliminating helicobacter pylori.

The invention discloses a strain of lactobacillus salivarius ZLp4b and its application in preventing and treating diarrhea of young animals. The strain has broad-spectrum bacteriostasis and can inhibit the growth of various pathogenic bacteria such as Escherichia coli, Salmonella, Staphylococcus aureus and PasteureUa multocida, etc. In addition, the strain has good in-vitro probiotic characteristics, including high gastrointestinal tolerance, high temperature tolerance and adhesion. As the lactobacillus salivarius of the invention is applied to feeding of mice and diarrhea piglets, lambs and calves, the secretion of immunoglobulin and cytokines in the serum of mice can be promoted, and the diarrhea symptoms of young animals can be cured or obviously alleviated.

The invention discloses a method for reducing heavy metal cadmium in rice through a fermentation technology. Common long-grain rice serves as the raw material, fermentation liquid naturally fermented in the fermentation rice noodle manufacturing process serves as a fermentation broth stock solution, in the fermentation broth stock solution, lactobacillus fermenti, lactobacillus salivarius, lactobacillus plantarum and lactobacillus reuteri are used as zymophyte, streptococcus thermophilus and lactobacillus bulgaricus are used as functional bacteria, and a mixed zymophyte solution is obtained; then, the common long-grain rice with cadmium exceeding the standard is added into warm water mixed with the zymophyte solution to be soaked, the mixed zymophyte solution is used for fermentation, and filtering, cleaning and centrifugal dripping are conducted in sequence after the fermentation process is completed. By means of the method, equipment input in the industrial production process of cadmium reducing in the rice can be effectively reduced, the operation technology is simplified, and the loss of rice starch in the subsequent cleaning process is reduced. It is verified that the cadmium content in the rice can be obviously reduced, and the cadmium content can be reduced by more than 90 percent to the maximum.

The invention discloses an antibacterial and whitening mouth care composition which comprises probiotics, a green tea extract and phytic acid in a mass ratio of 10:(10-20):(1-10), wherein the probiotics are one or a mixture of two of lactobacillus paracasei and lactobacillus salivarius; the probiotics are subjected to sterilization treatment. In the composition disclosed by the invention, the probiotics and the green tea extract are both active agents, the phytic acid is a stabilizer, and in the presence of the phytic acid, the compounding effect of the probiotics and tea polyphenol can be greatly improved; when being applied to a mouth wash product, the composition disclosed by the invention has very good effects of preventing bacteria, inhibiting dental plaque, whitening teeth, preventing decayed teeth, cleaning mouths and keeping gingival healthy.

The invention belongs to the technical field of lactobacillus cultivation, and relates to a high density fermentation medium for feeding lactobacillus, and a corresponding fermentation method. According to the present invention, a strategy of employing pH feedback to control glucose feeding is adopted, and the density of lactic acid in fermentation broth is reduced, such that feedback inhibition effect of lactic acid is released. With the fermentation medium and the fermentation method provided by the present invention, thalline density of cultivated saliva lactobacillus is substantially improved comparing to that obtained with common fermentation method, live bacteria content is no less than 10<10>cfu / ml, which is increased by 50 times or more than the content of live bacteria cultivatedwith a common MRS medium, such that high density fermentation of saliva lactobacillus is realized. Therefore, separating cost of biomass can be reduced, production period can be shortened, productioncost can be reduced, and production efficiency can be improved.

Use of at least one strain of a microorganism and / or a metabolite thereof in the manufacture of a support for administration to a subject for modulating satiety signalling, wherein the support is a pharmaceutically acceptable support or a food product. Suitably, the at least one strain of a microorganism and / or a metabolite thereof may be administered to the subject for the treatment and / or prevention of excess weight and / or a disease caused by excess weight. Likewise, the at least one strain of a microorganism and / or a metabolite thereof is administered to the subject for the treatment and / or prevention of obesity and / or a caused by obesity. Preferably, the microorganism is a probiotic microorganism. Suitably the microorganism may be a lactic acid bacterium. Li one embodiment the microorganism is a strain of Lactobacillus spp. and / or Bifidobacterium spp., for example a strain of Lactobacillus acidophilus, L. curvatus, L. salivarius and / or B. lactis.

The invention relates to a lactobacillus expansible vaginal suppository as well as a preparation method and a detection method thereof. The expansible vaginal suppository comprises an expansion vector and a drug-containing matrix which coats the surface of the expansion vector and is formed by lactobacilli and a matrix, wherein the lactobacilli include lactobacillus plantarum, lactobacillus acidophilus, lactobacillus fermentum, lactobacillus salivarius, lactobacillus crispatus, lactobacillus casei, lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus reuteri and lactobacillus bulgaricus, and the various lactobacilli can develop a significant synergistic effect together; and the drug-containing matrix further consists of an emulsifier, a sustained-release agent and carnauba wax. The lactobacillus expansible vaginal suppository provided by the invention, on the basis of seven unique advanced technologies, has effects of preventing effusion of medicine liquid, guaranteeing high stability, guaranteeing a lasting curative effect and the like.

The invention provides Lactobacillus salivarius M6, which is preserved in the China General Microbiological Culture Collection Center (CGMCC) with the number of CGMCC 3505. The invention also provides a lactobacillus which can be mixed with animal feed or added into water, can be used together with antibiotics at the same time, and has antibiotic resistance. The strain can inhibit growth of Salmonella enterica, Escherichia coli and other pathogenic bacteria. The antibacterial composition of the Lactobacillus salivarius M6 can be used in drinking water, drinking water additives, feed and food additives of animals, human and animal medical composition, as well as drinks, drinking additives, foods, food additives and the like of humans. By implementation of the invention, pathogenic bacterium infection of animals or humans can be effectively prevented and treated, and the number of intestinal probiotics can be increased or maintained, so that the growth of pathogenic bacteria is inhibited, the dosage of antibiotics is reduced, and the aim of preventing disease infection of animals and humans can be achieved.

Provided is a Lactobacillus salivarius belonging to Lactobacillus salivarius subsp. Salivarius and deposited in China General Microbiological Culture Collection Center with an accession number CGMCC No: 3606. Further provided is a method for preparing a metabolite of the Lactobacillus salivarius, wherein the Lactobacillus salivarius is as described above. Further provided is a composition, comprising viable strains of the Lactobacillus salivarius and / or the metabolite of the Lactobacillus salivarius prepared as described above. Further provided is a use of the composition in preparation of drugs for prevention and / or treatment of cancers and a method for treating and / or preventing cancers. The viable strains of Lactobacillus salivarius and the metabolite of Lactobacillus salivarius provided in the present invention can both remove the genotoxicity of 4-NQQ in vivo, thus exerting an effect of effectively preventing and / or treating cancers.

The present invention discloses a nutritional composition for improving oral health. The nutritional composition comprises the following raw materials in parts by weight: 5-30 parts of probiotics, 20-80 parts of prebiotics and 0.1-2 parts of epigallocatechin gallate; the probiotics are selected from at least one of lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus helveticus, and lactobacillus salivarius; and the prebiotics are selected from at least one of inulin, oligofructose, galactooligosaccharide, xylooligosaccharide, stachyose, oligoisomaltose, raffinose, trehalose, and lactitol. At the same time, the present invention also provides a use of the nutritional composition in preparations of oral health-care products. The provided nutritional composition can inhibit colonization of caries inducing streptococcus mutans, reduces adhesion of subgingival gingiva pathogenic bacteria, inhibits bad breath, promotes the proliferation of the oral probiotics, prevents the occurrence and development of dental erosion and oral cancers, and can effectively solve the oral problems caused by alcoholism, smoking, staying up late, irregular diet, long-term consumption of acidic substances, etc.

The present invention relates to a novel process for the selection of new probiotic strains which comprises the following steps: a) selecting for non-pathogenic strains which are capable of surviving in breast milk and / or amniotic fluid, and b) selecting for non-pathogenic strains which are able to be transferred to breast milk and / or amniotic fluid after oral intake in healthy individuals without colonizing other internal organs except mucousas. The invention also provides new Lactobacillus strains, which are: CECT5711 (Lactobacillus coryniformis), CECT5713 (Lactobacillus salivarius subsp. salivarius), CECT5714: (Lactobacillus gasseri, formerly L. acidophilus), CETC5715: (Lactobacillus gassen), and CECT5716: (Lactobacillus fermentum); and refers to their use for the prophylaxis or treatment against digestive, infective, neuro-degenerative and immune related diseases such as allergies or inflammatory diseases.

The invention discloses a lactic acid bacterium composition for treating vaginitis. The lactic acid bacterium composition comprises a lactic acid bacterium combined kernel which is coated by a coating layer. The coating layer comprises, by weight, 30 to 50 parts of isomaltooligosaccharide, 30 to 50 parts of a protein substance, 5 to 10 parts of cranberry powder, 5 to 10 parts of cellulose nitrate. The lactic acid bacterium combined kernel comprises the following strains by weight: 30 to 40 parts of Lactobacillus salivarius, 20 to 30 part of Lactobacillus reuteri, 10 to 20 parts of Lactobacillus rhamnosus and 10 to 20 parts of Lactobacillus acidophilus. The invention also discloses a preparation method for the composition. The lactic acid bacterium composition provided by the invention has the advantages of substantial treatment effect on vaginitis and no toxic and side effect.

Disclosed is a live bacterium preparation or food containing a lactic acid bacterium comprising a lactic acid bacterium, Lactobacillus salivarius, as an active ingredient. There is provided a live bacterium preparation and food containing a lactic acid bacterium that can prevent onset, recurrence and exacerbation of periodontal disease and / or dental caries caused by periodontopathic bacteria and cariogenic bacteria and can prevent generation of halitosis and maintain pH of saliva at a physiologically normal level by normalizing intraoral microflora.