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Lactobacillus expansible vaginal suppository as well as preparation method and detection method thereof

The technology of vaginal expansion suppository and detection method is applied in the field of lactic acid bacteria vaginal expansion suppository and its preparation, which can solve the problems of reducing the irritation of the expansion suppository, and achieve the effects of prolonging the action time, preventing the outflow of medicinal liquid and having high stability.

Inactive Publication Date: 2017-02-15
HARBIN OT PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Many preparations have been studied for the treatment of vaginitis. For example, CN103893107A discloses a sertaconazole nitrate vaginal expansive suppository, which includes a drug-containing matrix and an expansion carrier formed by sertaconazole nitrate and matrix; It also includes rosin glyceride, which reduces the irritation of the expansion suppository to the vagina; CN105012938A discloses a recombinant human interferon α2b vaginal expansion suppository, which includes a drug-containing matrix and an expansion carrier mainly formed of recombinant human interferon α2b and matrix; The drug-containing matrix is ​​added with Kudiding extract, which has a significant synergistic effect with recombinant human interferon α2b. However, these disclosed vaginal expansion suppositories are mainly used to treat a single type of vaginitis, which has certain limitations.

Method used

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  • Lactobacillus expansible vaginal suppository as well as preparation method and detection method thereof
  • Lactobacillus expansible vaginal suppository as well as preparation method and detection method thereof
  • Lactobacillus expansible vaginal suppository as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090]

[0091] Preparation:

[0092] 1) Preparation of drug-containing matrix:

[0093] a. heating and melting the substrate in a water bath to obtain a melt;

[0094] b. Mix the lactic acid bacteria evenly;

[0095] c. mixing the mixture of lactic acid bacteria and the sustained-release agent evenly to prepare the mixture;

[0096] d. The carnauba wax is placed in a water bath to be heated and melted, and the mixture of step c is added under stirring, and the mixture is uniformly mixed to obtain the mixture;

[0097] e. uniformly mixing the mixture of step d with the melt of step a to obtain a drug-containing matrix;

[0098] 2) Pour the drug-containing matrix into the suppository, insert the expansion carrier, cool and shape, and make a suppository, each weighing about 3.9g.

Embodiment 2

[0100] Compared with Example 1, the weight ratio of each bacterium of lactic acid bacteria is 1:3:3:2:6:1:2:4:3:4, and the contents of other components are the same as in Example 1.

[0101]

[0102] The preparation method is the same as in Example 1.

Embodiment 3

[0104] Compared with Example 1, the weight ratio of each bacterium of lactic acid bacteria is 1:4:3:2:7:3:2:4:3:7, and the contents of other components are the same as in Example 1.

[0105]

[0106]

[0107] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a lactobacillus expansible vaginal suppository as well as a preparation method and a detection method thereof. The expansible vaginal suppository comprises an expansion vector and a drug-containing matrix which coats the surface of the expansion vector and is formed by lactobacilli and a matrix, wherein the lactobacilli include lactobacillus plantarum, lactobacillus acidophilus, lactobacillus fermentum, lactobacillus salivarius, lactobacillus crispatus, lactobacillus casei, lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus reuteri and lactobacillus bulgaricus, and the various lactobacilli can develop a significant synergistic effect together; and the drug-containing matrix further consists of an emulsifier, a sustained-release agent and carnauba wax. The lactobacillus expansible vaginal suppository provided by the invention, on the basis of seven unique advanced technologies, has effects of preventing effusion of medicine liquid, guaranteeing high stability, guaranteeing a lasting curative effect and the like.

Description

technical field [0001] The invention relates to the field of vaginal suppositories, in particular to a lactic acid bacteria vaginal expansion suppository and a preparation method and a detection method thereof. Background technique [0002] Vaginitis refers to an inflammatory disease that occurs in the vaginal mucosa and submucosal connective tissue. It is a common and frequently-occurring disease in gynecology and can occur in women of all ages. Vaginitis can be divided into Bacterial vaginitis, trichomonas vaginitis, and fungal vaginitis; according to the released population, it can be divided into senile vaginitis, infantile vaginitis, girl menarche vaginitis, and pregnancy vaginitis; according to special periods, it can be divided into It is menstrual vaginitis and honeymoon vaginitis; according to the cause, it can be divided into allergic vaginitis, tight pants vaginitis and so on. [0003] Vaginitis is easy to recur, and the treatment is not thorough or timely. Howev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61K9/02A61K47/44A61K47/36A61K47/10G01N33/00G01N5/04A61P15/02
CPCA61K35/747A61K9/02A61K47/10A61K47/36A61K47/44G01N5/04G01N33/00A61K2300/00
Inventor 邱明世
Owner HARBIN OT PHARMA
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