The invention relates to a fluorine / butadiene rubber composite glove and a manufacturing method thereof, belonging to the technical field of labour protection appliances. The glove comprises a fiber glove lining, the surface of the fiber glove lining is coated with a butyronitrile emulsion layer, the surface of the butyronitrile emulsion layer is coated with a fluorine rubber layer, and fluorine rubber particles are sprayed on the surface of the fluorine rubber layer, wherein the butyronitrile emulsion layer comprises the components such as butyronitrile rubber, a vulcanizer and an activator,and the fluorine rubber cement comprises the components of the fluorine rubber, the vulcanizer, a vulcanization accelerator and an ester solvent. The method for manufacturing the glove comprises three steps burdening, soaking cement and pouring cement. The glove and the manufacturing method in the invention have the following advantages: the performances of resistances to chemicals, strong acid, strong alkali and corrosion are achieved, and the cost is lower; and meanwhile, the method for manufacturing the glove adopts a flow line production manner during the production process, the product process is simple, the cost is lowers, and the glove is applicable to large-scale industrialized production.