60 results about "Propionibacterium sp." patented technology

The present invention relates to a composition comprising one or more of bacterial strains, wherein the one or more of bacterial strains exhibit a stronger inhibition of pathogenic C. acnes strains compared to non-pathogenic C. acnes strains.

The invention discloses a short lipopeptide with specific anti-Propionibacterium acnes action and anti-inflammatory action, and belongs to the field of biotechnology. The short lipopeptide is composed of C6-C20 fatty acids and an amino acid sequence with the general formula KWKW. The short lipopeptide of the present invention can specifically inhibit the growth of Propionibacterium acnes and reduce the inflammatory response of tissues around hair follicles. In vivo and in vitro experiments show that the short lipopeptide of the present invention has high antibacterial and anti-inflammatory activities and low toxicity. In addition, the short lipopeptide has a different mechanism of action from traditional antibiotics, and the short lipopeptide is extremely difficult to produce drug resistance, especially effective for strains that have already developed resistance to existing antibiotics, so it can achieve the fundamentals of preventing and treating acne and improving the quality of life Purpose. The short lipopeptide of the present invention is a compound or complex containing lipids and amino acids, which can be added to various toiletries or cosmetics, is safe and environmentally friendly, and has broad market prospects.

The present invention proposes a method for cyclic fermentation of propionibacterium, comprising the following steps: (1) the cultured propionibacterium thallus enters a fermentation tank containing a culture medium for fermentation to obtain a fermentation liquid; (2) the step ( 1) The fermented liquid in 1) is subjected to ceramic membrane circulation filtration, and the fermented liquid supernatant liquid containing propionic acid is obtained by filtration, and the thalline concentrate liquid containing propionibacterium is sent to the fermentation tank, and fresh culture medium is added to carry out fermentation; (3) Circulation Step (2), until the acid production rate drops significantly, stop the cycle; (4) Repeat steps (1)-(3) to start a new round of cyclic fermentation of Propionibacterium. The invention adopts ceramic membrane filtration, realizes the recycling of the propionibacterium thallus, shortens the cultivation cycle of the propionibacterium thallus, reduces the production cost, and improves the production efficiency.

The invention discloses an external use type natural medicine composition for preventing and treating acne. The external use type natural medicine composition is prepared from the following componentsof herba sophorae alopecuroidis extract, herba nasturtii officinale extract and flos spiraeae ulmariae extract; or aloperine, sophoridine, herba nasturtii officinale extract, and flos spiraeae ulmariae extract. The invention also provides a preparation method of the external use type natural medicine composition. The external use type natural medicine composition has the advantages that the composition is a natural medicine extract or a single compound composition, the natural property is good, the side effect is small, the easiness in production of medicine resistance is avoided, and the like; proofed by test, the bacteria-inhibiting and anti-inflammatory functions are better, and the growth, proliferation and inflammation of propionibacterium acnes , staphylococcus epidermidis and staphylococcus aureus are inhibited; the effects of inhibiting bacteria, resisting inflammatory and inhibiting grease excretion are realized, and the irritation to skin is smaller after using for a long time; the aloperine and sophoridine components have good synergistic function, the better bacteria-inhibiting and anti-inflammatory treatment effects are realized, and the application prospect is betterin acne treatment.

Provided herein are, inter alia, compositions, systems, and methods for preventing or treating acne. Included are compositions, combinations, systems, and methods comprising at least one Propionibacterium acnes bacteriophage, at least one anti-acne compound, and a pharmaceutically acceptable carrier. Also included are compositions, combinations, and systems comprising a Propionibacterium acnes bacteriophage and an enzyme. Methods for preventing or treating acne are also provided.