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Compositions comprising propionibacterium acnes bacteriophages for treating acne

A technology of Propionibacterium acnes and a composition, which can be applied to bacteriophages, medical raw materials derived from viruses/phages, viruses/phages, etc., and can solve problems such as poor effects and the like

Pending Publication Date: 2020-02-14
PHI THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current treatments (including benzoyl peroxide and antibiotics) are very ineffective, and the most effective treatment - isotretinoin - is limited to a small number of patients due to dangerous side effects including birth defects, liver damage and suicide

Method used

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  • Compositions comprising propionibacterium acnes bacteriophages for treating acne
  • Compositions comprising propionibacterium acnes bacteriophages for treating acne
  • Compositions comprising propionibacterium acnes bacteriophages for treating acne

Examples

Experimental program
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Effect test

Embodiment approach

[0259] Embodiments and examples are provided below to assist in a more complete understanding of the invention. The following embodiments and examples illustrate exemplary modes of making and practicing the invention. However, the scope of the present invention is not limited to the specific embodiments disclosed in these embodiments and examples, which are for illustrative purposes only, as alternative approaches can be utilized to achieve a similar result.

[0260] Embodiments include the following embodiments P1 to P56:

Embodiment approach P1

[0261] Embodiment P1. A composition consisting essentially of at least one P. acnes bacteriophage, at least one anti-acne compound and a pharmaceutically acceptable carrier.

Embodiment approach P2

[0262] Embodiment P2. A composition comprising at least one P. acnes bacteriophage, at least one anti-acne compound and a pharmaceutically acceptable carrier, wherein said composition does not comprise probiotic bacteria.

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PUM

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Abstract

Provided herein are, inter alia, compositions, systems, and methods for preventing or treating acne. Included are compositions, combinations, systems, and methods comprising at least one Propionibacterium acnes bacteriophage, at least one anti-acne compound, and a pharmaceutically acceptable carrier. Also included are compositions, combinations, and systems comprising a Propionibacterium acnes bacteriophage and an enzyme. Methods for preventing or treating acne are also provided.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority of U.S. Provisional Application No. 62 / 488,326, filed April 21, 2017, which is hereby incorporated by reference in its entirety and / or in its entirety. [0003] governmental support [0004] This invention was made with Government support under Grant No. 1R43AR068172-01 awarded by the National Institutes of Health. The government has certain rights in this invention. [0005] Incorporation of Sequence Listings by Reference [0006] The entire contents of the 101,782-byte text file named "052004-503001WO_SequenceListing.TXT," created on April 20, 2018, are hereby incorporated by reference. Background technique [0007] Acne is a nearly worldwide condition that affects more than 80% of people worldwide. This chronic skin condition is complex, but the main causative agent is the bacterium Propionibacterium acnes, whose overgrowth causes inflammation that causes pimples. D...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/76A61K31/222A61K31/60A61K33/04A61K31/327A61K35/741A61K45/06C12N7/00A61P17/10
CPCA61K35/76C12N7/00A61P17/10C12N2795/10321C12N2795/10332A61K45/06A61K31/327A61K31/60A61K33/04A61K2300/00A61K31/05A61K38/47A61K38/48A61K38/446A61K9/107A61K9/0014A61K8/062A61K8/064A61K8/22A61K8/23A61K8/347A61K8/368A61K8/66A61K8/671A61K8/99A61Q19/00C12Y105/01001C12Y111/01C12Y304/21062C12Y304/21064
Inventor Y·瓦尔马N·万普鲁彦
Owner PHI THERAPEUTICS INC
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