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Composition with multi-target acne removing effect and preparation method and application of composition

A composition and multi-target technology, applied in the directions of medical preparations containing active ingredients, drug combinations, preparations for skin care, etc., to achieve the effects of simple preparation process, good inhibition effect, and inhibition of acne inflammation

Active Publication Date: 2020-07-28
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no reports of drugs that inhibit the release of P. acnes outer membrane vesicles. Therefore, there is an urgent need in this field for a composition with multi-target anti-acne effects to effectively inhibit the release of P. acnes outer membrane vesicles.

Method used

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  • Composition with multi-target acne removing effect and preparation method and application of composition
  • Composition with multi-target acne removing effect and preparation method and application of composition
  • Composition with multi-target acne removing effect and preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This example provides a traditional Chinese medicine extract with multi-target anti-acne effect and its preparation method:

[0037] (1) Sophora flavescens extract, its preparation method: dry Sophora flavescens to constant weight, pulverize, pass through a 60-mesh sieve, and use 80% ethanol solution to reflux extract for 1 hour according to the ratio of solid to liquid (g:mL) , stirring continuously, filtering after the first extraction, and extracting the residue once with 80% ethanol, filtering, merging the filtrate twice, rotating the filtrate to concentrate into an extract, and freeze-drying to obtain the Sophora flavescens extract ;

[0038] Artemisia argyi extract, its preparation method: dry the artemisia argyi leaves to constant weight, pulverize, pass through a 60-mesh sieve, use g:mL as 1:6 according to the ratio of material to liquid, reflux extraction with 60% ethanol solution for 1 hour, and keep stirring. Filter after the first extraction, extract the re...

Embodiment 2

[0051] This example provides a traditional Chinese medicine extract with multi-target anti-acne effect and its preparation method:

[0052] (1) The Sophora flavescens extract, its preparation method: dry Sophora flavescens to constant weight, pulverize, pass through a 60-mesh sieve, use g:mL as 1:8 according to the material-liquid ratio, and reflux with 80% ethanol solution Extract for 1 hour, keep stirring, filter after the first extraction, extract the residue once more with 80% ethanol, filter, combine the two filtrates, carry out rotary evaporation to concentrate the filtrate into an extract, and freeze-dry to obtain the Sophora flavescens Extract;

[0053] The preparation method of the Artemisia argyi leaf extract is as follows: dry the leaves of Artemisia argyi to constant weight, crush them, pass through a 60-mesh sieve, and use a 60% ethanol solution to reflux and extract for 1 hour without stopping Stir, filter after the first extraction, extract the residue once mor...

Embodiment 3

[0066] This example provides a traditional Chinese medicine extract with multi-target anti-acne effect and its preparation method:

[0067] (1) Sophora flavescens extract, its preparation method: dry Sophora flavescens to constant weight, pulverize, pass through a 60-mesh sieve, and use 80% ethanol solution to reflux extract for 1 hour according to the ratio of solid to liquid (g:mL) , stirring continuously, filtering after the first extraction, and extracting the residue once with 80% ethanol, filtering, merging the filtrate twice, rotating the filtrate to concentrate into an extract, and freeze-drying to obtain the Sophora flavescens extract ;

[0068] Artemisia argyi extract, its preparation method: dry the artemisia argyi leaves to constant weight, pulverize, pass through a 60-mesh sieve, use g:mL as 1:6 according to the ratio of material to liquid, reflux extraction with 60% ethanol solution for 1 hour, and keep stirring. Filter after the first extraction, extract the re...

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Abstract

The invention discloses a composition with a multi-target acne removal effect and a preparation method and application thereof. The composition comprises the following components in percentage by weight: 25%-50% of sophora flavescens extract, 25%-50% of folium artemisiae argyi extract and 10%-25% of honeysuckle extract. The inhibition of the formula of the composition on the propagation of propionibacterium acnes is embodied in a multi-target form, and the formula can ensure safety while ensuring that the formula has the effect of inhibiting acne inflammation. The sophora flavescens extract, the folium artemisiae argyi extract and the honeysuckle extract in the formula not only can inhibit propagation of propionibacterium acnes, but also can inhibit propionibacterium acnes from releasing outer membrane vesicles, and have the effect of inhibiting acne inflammation.

Description

technical field [0001] The invention belongs to the technical field of cosmetic preparation, and in particular relates to a composition with multi-target anti-acne effects, a preparation method and application thereof. Background technique [0002] Acne is a chronic inflammatory disease that occurs in the sebaceous glands, and the occurrence of acne is closely related to the activity of Propionibacterium acnes. Recent studies have found that Propionibacterium acnes can not only cause skin inflammation, but also the outer membrane vesicles released by it can cause intense inflammation. [0003] Thus, despite the inhibition of bacterial growth by antimicrobial agents, the presence of outer membrane vesicles prevented inflammation from being eradicated. Therefore, while effectively inhibiting bacteria, reducing the release of outer membrane vesicles and inhibiting the inflammatory response are the correct ways to relieve or cure acne. [0004] At present, there are no reports...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K36/282A61K36/355A61K36/489A61P17/14A61P31/04A61Q17/00A61Q19/00
CPCA61K36/282A61K36/355A61K36/489A61K2236/333A61K2236/53A61K2236/55A61K2800/5922A61K2800/84A61Q17/005A61Q19/00A61K8/9789A61P17/14A61P31/04A61K2300/00
Inventor 孙培冬魏静杨成
Owner JIANGNAN UNIV
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