52 results about "Miglitol" patented technology

The invention discloses an oral preparation for slowing down the absorption of an alpha-glycosidase inhibitor and enhancing a hypoglycemic drug effect. The preparation is an oral preparation prepared by adding the following adhesive auxiliary materials based on the certain proportion: carboxymethyl cellulose, hydroxyethyl cellulose, methyl cellulose or beta-cyclodextrin and the like, to each alpha-glycosidase inhibitor (acarbose, voglibose, miglitol, 1-deoxynojirimycin and extract of the 1-deoxynojirimycin). Compared with singly taken alpha-glycosidase inhibitors, the adhesives can be used for prolonging the action time of the alpha-glycosidase inhibitor in the intestine, slowing down the absorption of a medicament and glucose in the intestine and further reducing a plasma concentration, thus the hypoglycemic drug effect is improved. The oral preparation disclosed by the invention can be applied to the prevention and therapy of diseases, such as diabetes, obesity and the like.

Production of miglina is carried out by providing chiral center by L-phenylalanine. It achieves high efficiency and good optical purity, and to avoid chemical resolution and asymmetric hydrogenation.

The invention provides a method and bacterial strain for rapid quantitative detection of mutant strains of key intermediates of Miglitol. In the method, the mutagenized strains of wild Gluconobacter oxidans are subjected to fermentation and cultivation, and the fermented and cultivated mutant strains are obtained. Add the wet bacterial cells of the mutagenic strain to the substrate reaction solution. After the transformation reaction is complete at 15°C, centrifuge the reaction solution, measure the 6NSL content in the supernatant, and screen to obtain the key intermediate for the synthesis of miglitol according to the level of 6NSL content. highly active mutant strains. The detection method provided by the present invention has the characteristics of simplicity, quickness, high specificity, and good repeatability. The method can be further applied to the screening of high-activity Gluconobacter oxydans, effectively speeding up the breeding process, and transforming the mutant strains obtained through screening into synthetic rice. The catalytic ability of the glitol intermediate 6NSL has been significantly improved, and it is suitable for the industrialized large-scale production of miglitol.