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Medicine composition containing insulin intensifier and miglitol

An insulin sensitizer and composition technology are applied in the directions of drug combinations, medical preparations containing active ingredients, active ingredients of heterocyclic compounds, etc., to achieve the effects of increasing sensitivity, reducing complications, and controlling glucose uptake

Active Publication Date: 2008-02-13
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In conclusion, existing oral anti-diabetic drugs have many deficiencies. Combining the pathophysiological characteristics of diabetes and its complications, it is a research hotspot in the treatment of diabetes to expand the thinking and find new types of drugs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] prescription

[0027] Rosiglitazone 1.5g

[0028] Miglitol 20g

[0029] Microcrystalline Cellulose 100g

[0030] 8% hydroxypropyl methylcellulose solution appropriate amount

[0031] Low-substituted hydroxypropyl cellulose 50g

[0032] Magnesium Stearate 2g

[0033] Preparation process: rosiglitazone and miglitol are passed through a 100-mesh sieve, microcrystalline cellulose and low-substituted hydroxypropyl cellulose are passed through a 80-mesh sieve, and the prescribed amount of rosiglitazone, miglitol and low Replace hydroxypropyl cellulose and microcrystalline cellulose, mix evenly, add 8% hydroxypropyl methylcellulose solution to granulate in an appropriate amount, dry at 60°C, granulate with a 16-mesh sieve, and add prescription amount of magnesium stearate to the dry granules Mix well and press into tablets.

Embodiment 2

[0035] Pioglitazone 10g

[0036] Miglitol 20g

[0037] Microcrystalline Cellulose 100g

[0038] PEG6% solution appropriate amount

[0039] Carboxymethyl Cellulose Calcium 15g

[0040] Magnesium Stearate 2g

[0041] Preparation process: with embodiment 1.

Embodiment 3

[0043] Pioglitazone 10g

[0044] Miglitol 20g

[0045] 150g pregelatinized starch

[0046] Sodium carboxymethyl cellulose 1% solution appropriate amount

[0047] Enteric coating powder appropriate amount

[0048] Carboxymethyl Cellulose Calcium 15g

[0049] Magnesium Stearate 2g

[0050] Preparation process: According to the conventional tablet process, it is made into tablets (ball cores) of required specifications, and then coated with enteric coating powder.

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PUM

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Abstract

The present invention relates to an oral blood-sugar-reducing compound medicinal preparation, which consists of an insulin sensitizer, a miglitol and auxiliary materials. Compared with the prior art, the present invention is characterized in that under a circumstance of a same curative effect, a separate dosage of the insulin sensitizer or the miglitol is reduced; at the same time compared with other hypoglycemic drugs, a side effect of the present invention is reduced; the insulin sensitizer and the miglitol have a synergistic effect: the insulin sensitizer and the miglitol respectively take curative actions towards a patient with hyperglycemia synchronously according to the different pharmacological effects and directly provide the patient or a doctor with a scientific combined medication to improve the curative effect and provide a clinic or the patient with convenience.

Description

technical field [0001] The invention belongs to a new pharmaceutical composition for treating diabetes. Background technique [0002] The incidence of diabetes is still increasing year by year. According to the data provided by the World Health Organization (WHO), the prevalence of diabetes in developed countries has reached 5% to 10%, while in my country it is about 3%. There are 130 million diabetic patients in the world; by 2030, the number of diabetic patients in the world will double that of 2000. It is noteworthy that the prevalence of diabetes is increasing particularly rapidly in developing countries, especially those developing countries that are going from poor to rich. Diabetes is not just a disease of the rich. In areas where the economy and living standards have undergone drastic changes, there is a real danger of diabetes outbreaks. Diabetes in my country is in an explosive epidemic. Diabetic complications plague patients and the medical community: if diabet...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K31/454A61K31/445A61K31/4439A61K47/38A61K9/20A61K9/48A61P3/10
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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