The invention discloses a powder metallurgy fabrication method of a hollow metal sphere, which comprises the following steps of placing a polystyrene sphere in a centrifugal mold, preparing slurry 1 with metal powder, adhesive solution and a defoaming agent, pouring the slurry 1 into the centrifugal mold, centrifuging, putting the centrifuged polystyrene sphere in an oven for drying together with the centrifugal mold, preparing slurry 2 with the metal powder, the adhesive solution and the defoaming agent, pouring the slurry 2 into the dried centrifugal mold, centrifuging, putting the centrifuged polystyrene sphere in the oven for drying together with the centrifugal mold, taking out the dried polystyrene sphere from the centrifugal mold, embedding the polystyrene sphere into alumina packing, and then putting in a vacuum furnace for pyrolysis and sintering, thereby obtaining the hollow metal sphere. The method is reasonable in design, simple in process and low in cost. The hollow metal sphere fabricated by the fabrication method has the advantages of uniform, smooth and complete spherical shell wall thickness, facilitation of sphere dimension selection, easiness in overall structure control and the like.