The invention provides an antidepressant traditional Chinese medicine composition, which is prepared from the following components in parts by weight: 15-50 parts of gypsum, 3-10 parts of rhizoma anemarrhenae, 10-30 parts of uncaria rhynchophylla, 3-10 parts of radix ophiopogonis, 5-15 parts of rehmanniae praeparatum, 5-15 parts of Inula japonica, 3-15 parts of officinal magnolia bark, 3-15 parts of medicinal cyathula root, 3-10 parts of raw hematite,10-30 parts of rhizoma phragmitis, 3-10 parts of immature bitter orange and 3-12 parts of semen raphani. The antidepressant traditional Chinese medicine composition in the invention has the following beneficial effects: (1) the composition can cure depression effectively; (2) as for curative effect, the composition is similar to or stronger than fluoxetine hydrochloride, and the composition has the functions of invigorating food stagnation and relaxing bowel; (3) as for price, the cost of the composition is lower than that of fluoxetine hydrochloride; and (4) in long-term clinic observation, side effects such as excitement, anxiety, thirsty, hydrosis, headache, drowsiness in day, insomnia at night, astriction and sexual dysfunction, damaged liver kidney function and the like do not occur.