150 results about "Cutaneous absorption" patented technology

A method of relieving analgesia and reducing inflammation using a cannabinoid delivery topical liniment composition containing from about 97.5% to about 99.5% by weight a 70% monohydric alcohol solution, and from about 0.5% to about 2.5% by weight of a synergistic cannabinoid mixture extracted from the female plant Cannabis sativa L, including in combination: 9-Tetrahydrocannabinol (delta-9-THC), 9-THC Propyl Analogue (THC-V), Cannabidiol (CBD), Cannabidiol Propyl Analogue (CBD-V), Cannabinol (CBN), Cannabichromene (CBC), Cannabichromene Propyl Analogue (CBC-V), Cannabigerol (CBG), terpenoids, and flavonoids. The liniment is applied topically, preferably by spraying, and the constituents of the mixture are absorbed through the skin and interact with cannabinoid receptors in the body and tissues of a human patient to produce therapeutic analgesic and anti-inflammatory effects without undesirable psychotropic side effects.

Absorption of a therapeutic agent across a mucosal membrane or the skin can be enhanced using an absorption enhancer comprising a hydroxy fatty acid ester of polyethylene glycol.

The present invention discloses a human body affinitive lubricating protective and repair gel, which combines photocatalyst (TiO2) particles with a disinfection material such as nano silver to produce a TiO2Ag compound, and mixes the compound with a filtered natural biological organism with a molecular weight below 50 Kbp and a concentration of 0.05˜5% including small molecules of collagen, chitin, chitosan, hyaluronic acid, vitamin C, and nano iron, and its pH value is adjusted to 6 which is close to the pH value of our skin, and thus the mixture constitutes a gel affinitive to human skins and non-toxic to human cells. An accessory ingredient such as an aromatic agent, a detergent, or a cosmetic agent is added in the manufacturing process to produce an emulsion or a paste for coating or spraying, which is used as a health or sanitation item such as a hand liquid soap, a cosmetic, a shampoo, or a disinfectant. The feature of the small diameter of the particles (1˜100 n / m) can penetrate the cuticle of our skin and remain at the derma inside the skin pores to produce a protective film, and the collagen can be absorbed by the skin to give the effects of repairing tissues, stopping bleeding, and lubricating skins. With the cyclic disinfection effect of the TiO2Ag compound, a deeper clean skin to prevent germs is obtained and a disinfection effect is achieved to eliminate acnes and pimples. The present invention also makes use of an oxidation-reduction mechanism of the photocatalyst (TiO2) to achieve long-hour disinfection and naturally remove germs.

The invention discloses a whitening mask which is prepared by dipping a liquid prepared from the following raw materials in parts by weight: 0.1-3 parts of micromolecular hyaluronic acid, 0.1-2.5 parts of macromolecular hyaluronic acid, 0.7-30 parts of synthetic egg white powder, 1-7 parts of an aloe extract, 0.7-9 parts of propylene glycol, 5-50 parts of 1,2-butanediol, 5-30 parts of glycerinum, 40-80 parts of a ginseng extract liquid, 0.1-1 part of glabridin, 0.3-2 parts of alpha-arbutin, 0.1-1 part of phloretin, 0.1-1 part of apple stem cells, 1-5 parts of raspberry ketone glucoside, 0.1-1 part of tetrahydropiperine, 1-10 parts of vitamin c ethyl ether, 1-5 parts of tranexamic acid, 1-10 parts of hydrolyzed pearl and added to 1000 parts of water on mask paper. The whitening mask has the efficacies of promoting skin absorption of various effective components, repairing damaged cells, activating resting cells, promoting cell regeneration, moisturizing the skin, rapidly and efficiently whitening the skin and removing freckles, and is free of irritation, allergy or damage to the skin.

This present invention provides a percutaneous absorption type pharmaceutical preparation which includes 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide as the active ingredient and a backbone for transdermal system, and satisfies at least one of the following conditions (1) and (2). The pharmaceutical preparation of the present invention enables absorption of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide, which has a low ability to be absorbed from the skin, from the skin into the body continuously and efficiently.(1) The active ingredient content in one preparation or one time administration preparation is from about 0.1 mg to about 10 mg,(2) the size is from about 1 cm2 to about 300 cm2.

A formulation of supplement is able to boost the natural cells, both increasing the population of the natural cells and enhancing the natural cell's activity. The formulation can be administered via different forms, such as tablet, injection, skin absorption and etc. This formulation comprises 16 different components, including Alpha Lipoic Acid, Arabinoxylin, Curcumin, Garlic, Genistein, Ginseng, Lentinan, Mistletoe, N-Acetylcysteine, Resveratrol, Selenium, Vitamin B Complex, Vitamin C, Vitamin D3, Vitamin E and Zinc. By virtue of enhancing the natural killer cells (NKC) in the body, the formation is helpful for the prevention and treatment of a number of different human or animal diseases, such as cancers and viral infections. In addition, certain synergistic effects have been observed between different components in the formulation, which further enhances the beneficial effect of the formulation.

The invention relates to a skin radiation-preventing composition, in particular to a skin radiation-preventing composition, which comprises the following components in percentage by mass: 20 to 35 percent of vitamin E, 20 to 35 percent of vitamin C, 10 to 25 percent of pollen, 20 to 30 percent of houttuynia cordata ethanol leaching liquid, 5 to 10 percent of natural extract, 5 to 10 percent of diguanosine tetraphosphate and 1 to 2 percent of inorganic salt. The components are prepared into solution by using distillated water, and elements are added in an amount which is 0.001 to 0.01 percent based on the total weight of mass of the previous components. The skin radiation-preventing composition, which is provided by the invention, can be externally sprayed and applied onto skin to effectively increase the radiation resistance of skin; as a liquid composition, the adopted natural extract can be absorbed by skin easily, can penetrate into skin, is not greasy and avoids blocking pores andwashing; and the skin radiation-preventing composition can be used in place of common moisturizing lotion and has good moisturizing and skin-care effects.

The invention relates to a skin whitening cream. The skin whitening cream comprises the following components in parts by weight: 0.05-0.08 part of melatonin, 3-5 parts of plant extract, 0.3-0.6 part of levorotatory VC, 10-25 parts of plant oil, 0.5-2.5 parts of arbutin, 2-6 parts of emulsifier, 4-8 parts of humectants, 0.2-0.4 part of essence, 0.1-0.3 part of Paraben, and 65-85 parts of water. The plant oil is olive oil or castor oil, and the humectant is one or more of glycerol, hyaluronic acid and tartaric acid. The main component of the skin whitening cream provided by the invention is a skin whitening cream extract with a skin whitening effect. The skin whitening cream provided by the invention has the advantages that the skin whitening cream has a favorable skin whitening effect, and is temperate and inirritative. In addition, the skin whitening cream is specially added with the melatonin. Through the cutaneous absorption, the melanin of the skin can be reduced, and the composition of the melanin of the human body can be blocked, so that the skin whitening cream can fundamentally whiten the skin, and also delay the skin aging. The plant oil replaces the chemical grease, so that the skin whitening cream is rapid to absorb, natural and safe.

The invention discloses a whitening freckle-removing lipidosome and a preparation method and an application of the whitening freckle-removing lipidosome. A whitening freckle-removing lipidosome composition is prepared from 5-30% of whitening and freckle-removing ingredients, 1-40% of polyhydric alcohol, 1-25% of phospholipid, 1-25% of grease, 1-15% of an emulsifying agent and deionized water. Thewhitening and freckle-removing ingredients comprising various components are screened through a large number of experiments, experiment results show that the provided whitening and freckle-removing ingredients have obvious effects on reducing melanogenesis and the like; the various whitening and freckle-removing ingredients are coated by the lecithin, can much easily permeate into the deep layer of the skin as the structures of the lecithin and the lipid structure of the skin are quite similar, and have the advantage of better skin absorption; the whitening and freckle-removing ingredients coated by the lecithin are isolated from the air, so that the problem of oxidation stain is avoided, and the stability is improved. According to a whitening and freckle-removing product prepared by usingthe lipidosome, the whitening and freckle-removing ingredients are slowly released, and the effects of whitening and removing freckles for a long period of time are achieved.

The invention discloses an active matter rapid infiltration system containing hemp extract or cannabidiol to increase the release speed and skin absorption speed of cosmetics and preparations for external use containing hemp extract or cannabidiol. The invention further provides application of the hemp extract or cannabidiol in preparation of cosmetics, with the cosmetics being provided with the rapid infiltration system.

The invention belongs to the technical field of cosmetics, and particularly relates to an anti-wrinkle composition for skin around eyes. The anti-wrinkle composition for the skin around eyes comprisesthe following components: in parts by weight, 0.1-0.5 part of retinoid aldehyde, 0.2-2 parts of a compound polypeptide, 0.2-5 parts of white birch extract, 0.2-1.5 parts of steroids and 20-40 parts of solvents. The anti-wrinkle composition for the skin around eyes is prepared by using the compound polypeptide, the retinoid aldehyde, the white birch extract and the steroids as active ingredients;when the anti-wrinkle composition is applied to eye cream, not only can anti-wrinkle, whitening and moisturizing effects be achieved, but also the problems of poor solubility, poor stability and no easy absorption by the skin of the eye cream can be solved; and skin irritation, eye edema, black eyes and eyelid pouch can also be reduced significantly, visual fatigue can be relieved, and the eye cream can be applied to prevention and treatment of eye diseases, no fat granules, pimples and other side effects are generated, and lasting effects can be obtained.

The invention belongs to the field of cosmetics and particularly relates to hirudin anti-winkle face-softening conditioning cream and a production process thereof. The conditioning cream is prepared by oil phase raw materials such as squalane, hexadecyl alcohol / hexadecyl glucoside, jojoba oil, glyceryl monostearate / PEG (polyethylene glycol)-100 stearate and dimethyl silicon oil, and water phase raw materials such as hirudin, oat polypeptide, oat beta-glucan, D panthenol, collagen polypeptide, a saffron crocus extracting solution and a ginseng extract. The production process comprises the steps of heating, sterilization, stirring, dissolving, emulsifying, homogenizing, cooling, discharging, sampling, detecting, filling, and packaging to obtain the conditioning cream. The conditioning cream can directly permeate into a corium layer of skin autonomously, can be easily absorbed by the skin, can solve the problems such as presenility of the skin and wrinkles of eyes caused by unsmooth blood circulation, is very good in wrinkle-removing effect, improves facial microcirculation, and has a function of improving the skin quality; as multiple moisture-keeping, skin-moisturizing and oxidation-resisting raw materials are added, the conditioning cream has very good whitening and nourishing effects; and the production process is simple and easy to operate.

The invention discloses a whitening composition and the application thereof in whitening cosmetics. The whitening composition contains the following components in weight percentage: 1-10% of lipid soluble VC derivatives, 0.05-0.2% of Glabridin, 1-5% of nicotinamide, 1-5% of hydrogenated soya lecithin, 0.1-0.5% of a gorgonia extracting solution and 0.5-2% of an amino-acid humectant. According to the whitening composition prepared by the invention, the whitening and speckle removing effects are obvious, the whitening composition can be quickly adsorbed by skin, the irritation to the skin is weak and the obvious moisture-holding, anti-inflammatory and antiallergic effects and effective skin brightening effect are realized.

The invention provides a repairing and freckle removing type facial cleanser which is prepared from the following components by mass percent: 20-30% of glyceryl stearate, 8-12% of a sheep placenta extract, 5-10% of natural propolis, 1-3% of hyaluronic acid and the balance of refined water. The invention further provides a preparation method thereof. According to the prepared repairing and freckle removing type facial cleanser which contains sheep placenta extracts, various nutritional ingredients of the sheep placenta are fully extracted by utilizing an enzymolysis method and separated into micro-molecular substances, and the micro-molecular substances are easy to absorb by skin; after using for a long term, the facial cleanser can improve such skin states as drying, multiple freckles and low elasticity, and nourishes the skin when removing the freckles, so that the skin is always in a virtuous cycle state. The repairing and freckle removing type facial cleanser cannot be replaced with a normal facial cleanser.

The invention discloses a Chinese herbal medicinal gel cosmetic and a preparation method thereof. The cosmetic contains 0.03 to 3 percent of Chinese herbal medicine active ingredients, 3 to 5 percent of emulsifier, a Carbomer, a hyasol, distilled water and the like. The preparation method comprises the following steps of: coating the Chinese herbal medicine active ingredients into a transparent oily matter by using the emulsifier; and adding the Carbomer, a pH regulator, the hyasol, an essence and the distilled water to prepare the Chinese herbal medicinal gel cosmetic. The Chinese herbal medicine active ingredients are from the nature and have high safety for a human body; through the synergism of various Chinese herbal medicine active ingredients in the cosmetic, the cosmetic has double effects of whitening and antioxidation; and the gel has a transparent texture and is more easily absorbed by skin, so the cosmetic has good appearance and function.

The invention relates to freckle-removing skin oil and an application method thereof. The freckle-removing skin oil comprises, by weight, 30-48 parts of jojoba oil, 10-15 parts of hydrogenated almond oil, 10-15 parts of hydrogenated safflower oil, 10-15 parts of lavender oil, 5-10 parts of sweet orange oil, 5-10 parts of bergamot fruit oil, 3-8 parts of rose oil, 0.5-1 part of ascorbic acid palmitate and 0.1-0.3 part of liquorice-type flavonoid. The application method includes 1), cleaning the face; 2), evenly smearing the freckle-removing skin oil on the face and / or the neck, and massaging skin parts with freckles until the skin oil is absorbed by the skin. The freckle-removing skin oil and the application method thereof have the advantages that by the freckle-removing skin oil high in permeability, chromatosis can be reduced, melanin generation can be inhibited, skin color can be conditioned, moisturizing, whitening and freckle removing effects can be achieved, and the skin can become bright; moreover, the freckle-removing skin oil has high safety, and the application method is simple and easy to operate.

The invention discloses an anti-aging lotion. The anti-aging lotion comprises the following components in parts by weight: 14.5-16.5 parts of a moisturizing agent, 10.2-13.8 parts of an emollient, 2.50-3.50 parts of a peptide composition, 1.70-2.80 parts of a skin conditioning agent, 0.3-0.6 part of a thickening agent, 1.50-2.50 parts of an emulsifying agent, 3.00-4.50 parts of other base materialand the balance of water. The specific type of peptide composition is added into the lotion according to a specific compounding ratio, the peptide composition has the molecular weight as low as 1000Daltons and is easily absorbed by the skin, and under assistance of the specific types of the moisturizing agent, the emollient, the skin conditioning agent and other components with specific contents, the prepared lotion has a more significantly improved anti-aging effect; in addition, a final product does not contain any harmful additive (such as a film forming agent) and does not damage skin; apreparation technology thereof is simple, low in energy consumption, low in economic cost, environment-friendly and safe and has a good industrial application prospect.

The invention discloses a cosmetic composition capable of invigorating blood circulation. The cosmetic composition comprises the following constituents in parts by weight: 1-40 parts of plant extract, 19.5-33.5 parts of an emollient, 4.5-7.5 parts of an emulsifier, 5-10 parts of a moisturizer, 1-1.4 parts of a skin conditioner, 0.3-0.8 part of a penetration enhancer, 0.24-0.34 part of a thickening agent, 0.24-0.32 part of a preservative, 0.06-0.07 part of a neutralizer, and 5-70 parts of water, wherein the plant extract is a mixed liquid of dendrobe extract, rhizoma sparganii extract, codonopsis pilosula extract and angelica sinensis extract. According to the cosmetic composition disclosed by the invention, the mixed liquid of the dendrobe extract, the rhizoma sparganii extract, the codonopsis pilosula extract and the angelica sinensis extract is added to the cosmetic composition capable of invigorating blood circulation, so that the cosmetic composition is mild in constituents, synergistic to play an effect enhancing role, and stable in system; the cosmetic composition is used as a novel foot nursing cosmetic; when being used, the cream can be smeared on the feet which are repeatedly massaged to promote cutaneous absorption, so as to effectively moisturize the skin of the feet and legs, achieve the blood circulation invigorating effect, prevent and relieve the foot problems such as foot pain, sole vellication, sole numb, foot weakness and dry skin.

The invention relates to a preparation method of micromolecular dendrobium officinale polysaccharide. A dendrobium officinale dried product is used as a starting raw material, and the micromolecularden drobium dendrobium officinale polysaccharide is obtained through a deep eutectic solvent and subcritical extraction. According to the preparation method of the micromolecular dendrobium officinale polysaccharide, the dendrobium officinale polysaccharide with the molecular weight smaller than or equal to 50 kD can be prepared, and the dendrobium officinale polysaccharide with the molecular weight smaller than or equal to 50 kD further has the advantages of being high in purity and high in extraction rate. The micromolecular dendrobium officinale polysaccharide with the molecular weight smaller than or equal to 50 kDa is small in molecular weight, high in purity, beneficial to skin absorption, capable of remarkably improving the skin immune barrier effect and good in anti-inflammatory effect.

The invention discloses a sleep mask with functions of acne treatment and beautifying and a preparation method of the sleep mask. The sleep mask is prepared from peach blossoms, Hylocereus undatus, lycopene, rhizoma dioscoreae and potato juice, aloes, bee propolis, Herba Centellae, vitamin E, green tea extract, kelps, Cortex Dictamni, calendula, pearl powder, tetracycline and tea tree oil. The sleep mask is nonirritant and free of anaphylaxis, the method is convenient to operate, simple and feasible, and cheap raw materials, low cost, low energy consumption and high product added value are realized. The peach blossoms are rich in vegetable proteins and free amino acids easy for skin to absorb, evident effects of prevention and treatment of dry skin, rough skin, wrinkles and the like are realized, blood circulation can be improved, skin nutrition and oxygen supply is promoted, and excretion of lipofuscin which accelerates aging is accelerated. In addition, the raw materials include not only foods and vegetables with the function of acne mark removal but also medicinal materials with the function of acne mark removal, so that effectiveness in acne mark removal is achieved.

The invention discloses an anti-radiation and skin-care composition, and relates to the technical field of skin-care cosmetics for daily use. The skin-care composition is prepared from the following components in parts by weight: 5-10 parts of rutin, 0-10 parts of lycopene, 10-25 parts of a green tea extract, 15-25 parts of diguanosinetetraphosphate CAS, 25-60 parts of a grape peel extract, 15-25 parts of an algae extract, 20-50 parts of a traditional Chinese medicine extract, 10-25 parts of an extract of lycium ruthenicum murr, 1-10 parts of vitamin and 1-5 parts of trace elements. The skin-care composition disclosed by the invention is in the form of a liquid which is easy to be absorbed by skin and good in effect of resisting electromagnetic radiation; and the skin-care composition also has functions of moisturizing and whitening, repairing cell injury caused by electromagnetic radiation, resisting oxidation and resisting free radicals, and delaying skin aging.

The invention belongs to the technical field of cosmetics and particularly relates to sea urchin polypeptide face cream and a preparation method thereof. The sea urchin polypeptide face cream is prepared from components as follows: sea urchin polypeptides, hemp oil, olive oil, an emulsifier, a moisturizer, a thickener, a preservative and distilled water. The sea urchin polypeptide face cream and the preparation method have the beneficial effects as follows: discarded internal organs of sea urchin processing are subjected to enzymolysis, separation, purification and other treatment, sea urchin polypeptides with molecular size being 1kD-10 kD are extracted and have the characteristics of being free from foreign odor, good in water solubility and easily absorbed by skin, then the sea urchin polypeptides are mixed with other components, the prepared face cream has the advantages of being free from foreign odor and easy to absorb, metabolism of skin cells can be promoted, and skin moisture and elasticity are kept.

The invention provides a patch device adapted for use in the transdermal administration to a patient of a composition including one or more pharmaceutically, cosmetically, pesticidally, prophylactically, and nutritionally active substance, the patch consisting of a layered construct adapted to be adhered to the skin of a patient and defining a cavity for receiving one or more disruptable containers of the composition or components of the composition to be administered between a proximal layer and a distal layer thereof, which proximal layer is adapted in use to be located in intimate contact with the skin of the patient and which distal layer is in use disposed on the outer side thereof, wherein the proximal layer is partially permeable to that composition, so that in use the integrity of the one or more containers may be disrupted thereby causing the composition to be disposed in the cavity and permeate from there through the proximal layer to be absorbed through the skin into the body of the patient. The invention further provides a method of applying an irritant to the skin of a user.

The invention discloses a traditional Chinese medicine for promoting blood circulation, removing blood stasis and clearing and activating channels and collaterals. A prescription principle of principal, subordinate, adjuvant, and guide is taken; monkshood and radix aconiti agrestis are taken as principal drugs and are used for dispelling wind and eliminating dampness, penetrating channels and collaterals, and eliminating cold to stop pain; bile arisaema, frankincense and myrrh are taken as subordinate drugs and are used for expelling wind, relieving convulsion and relieving swelling and pain; root of common peony, red flower, ligusticum wallichii, radix achyranthis bidentatae, eucommia ulmoides and cassia twig are taken as adjuvant drugs and are used for removing heat to cool blood, invigorating the circulation of blood, promoting the circulation of qi, stimulating the menstrual flow and dispersing stagnate; and lumbricus is taken as guide drug and is used for adding the effects of clearing heat, eliminating wind, dredging collaterals and stopping pain and numbness. Through decocting with water and washout, the traditional Chinese medicine is capable of promoting blood circulation, removing blood stasis and clearing and activating channels and collaterals, so as to recover the muscle function and promote blood circulation and nerve conduction; the traditional Chinese medicine is an effective prescription for treating limb numbness caused by various reasons; the treating method belongs to a physical therapeutic method; and the method for treating an internal illness by external treatment by applying the traditional Chinese medicine and a modern pharmaceutical transdermal absorption theory are applied, so that the cutaneous absorption is quick, the bioavailability is high and no toxic side effect exists.

The invention discloses a drug for treating cervical and lumbar spondylosis. The drug mainly comprises lycopodium clavatum, caulis spatholobi, folium artemisiae argyi, chaenomeles speciosa, radix clematidis, ramulus mori, cortex acanthopanacis, angelica sinensis, notopterygium and phryma leptostachya. The invention further discloses a using method of the drug for treating cervical and lumbar spondylosis. The using method comprises the steps of mixing thedrug with 2-10 kg water and conducting heating so that cervical and lumbar diseased regions can be fumigated through steam. Fumigation is conducted once to twice each day and lasts for 40-50 min each time. By means of the fumigation therapy and the principle that lung governs the skin and hair and opening and closing of sweat pores, through the dispersion of Lung qi, the skin can breathe too, so that gas and medicine exchange is achieved, and medicine directly acts on the skin of the affected part, is absorbed through the skin and then enters the affected part to achieve treatment; meanwhile, the acupoint of the affected part is stimulated, the channel qi of the affected part is stimulated and regulated, the channel of the affected part is unblocked, and then treatment is achieved.

The present invention relates to applications of calcium amino acid chelate in preparation of a percutaneous absorption preparation. According to the present invention, the body is supplemented with calcium and amino acid through skin absorption, wherein the body can be preferentially supplemented with the required ion type calcium having physiological activity to the maximal degree through the percutaneous absorption manner, and specifically the calcium supplementing way through the percutaneous absorption can directly and rapidly supplement calcium to the epidermis system with no blood circulation system, such that the problem that the absorption rate of the orally-supplemented calcium is low, and the ion type calcium having physiological activity is insufficient due to the non-physiological-activity combined calcium firstly formed for bone forming after the absorption are solved; and the percutaneous absorption calcium amino acid chelate can be used for preparation of external application pharmaceutical preparations, medical and health materials, external application health product preparations, and cosmetics.

The invention discloses a cosmetic composition having effects of increasing skin elasticity and resisting wrinkle and an application thereof. The cosmetic composition contains 0.01% to 1.0% of ceramide, 0.001% to 0.1% of palmitoyl oligopeptide, 0.05% to 1.0% of royal jelly and 0.25% to 5% of lecithin. The weight ratio of royal jelly (on a dry weight basis) to lecithin is 1: 5. The cosmetic composition exists in a form of a two-layer lipsome aqueous solution with particle diameters of 30 nm to 130 nm. The cosmetic composition contains ceramide, palmitoyl oligopeptide, royal jelly and lecithin.The cosmetic composition can improve skin wrinkles, improve skin elasticity and recover skin functions. The two-layer lipsome aqueous solution improves the stability of royal jelly in the product andhelps the skin to absorb royal jelly.

The invention belongs to the technical field of plaster preparations. The external plaster for activating blood and relieving pain is prepared from the following raw materials: borneol, camphor, a controlled release formulation, rhizoma chuanxiong liquid extract, peppermint oil, cinnamic aldehyde, zinc oxide, vaseline, rosin, wool fat, liquid paraffin, a transdermal enhancer, a tackifier, an emulsion enhancer, dimethyl sulfoxide and rubber, wherein the controlled release formulation is one of nano-scale cocoanut active charcoal, silane coupling agent modified silica powder or alpha-cyclodextrin. The external plaster for activating blood and relieving pain, disclosed by the invention, has the obvious effects of activating blood and relieving pain, good transdermal absorption ratio and quick effects; effective ingredients in the plaster are slow to volatilize; the plaster is good in viscidity and homogeneous in quality. Meanwhile, in the preparation process, the materials are prepared into nano-scale emulsified slurry and then an adhesive is coated, so that components of the external plaster are more easily absorbed by the skin.