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Whitening freckle-removing lipidosome and preparation method and application of whitening freckle-removing lipidosome

A whitening and freckle-removing technology, which is applied in the field of whitening and freckle-removing compositions, can solve the problems that the whitening and freckle-removing ingredients cannot effectively inhibit melanin, the structure is unstable, and the irritation is large, so as to overcome the difficulty of being absorbed by the skin, reduce the production of melanin, and overcome the The effect of oxidative discoloration

Inactive Publication Date: 2018-05-01
连云港本草美汇医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the common whitening and freckle-removing ingredients on the market mainly include: arbutin, glabridin, azelaic acid and its derivatives, nicotinamide, hesperidin, ascorbic acid and its derivatives, vitamin A acids, fruit acids, water Salicylic acid, rutin, resveratrol, proanthocyanidins, ellagic acid, and tetrahydrocurcumin, but these whitening and freckle-removing ingredients have problems such as poor solubility, high irritation, unstable structure, and single action mechanism in cosmetics
In addition, melanin is produced through a series of complex biochemical reactions, which can be inhibited from multiple aspects. A single whitening and freckle-removing ingredient cannot effectively inhibit the production of melanin

Method used

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  • Whitening freckle-removing lipidosome and preparation method and application of whitening freckle-removing lipidosome
  • Whitening freckle-removing lipidosome and preparation method and application of whitening freckle-removing lipidosome
  • Whitening freckle-removing lipidosome and preparation method and application of whitening freckle-removing lipidosome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The preparation method of whitening and freckle removing liposome comprises the following steps:

[0044] (1) 4% arbutin, 2% ascorbyl glucoside, 3% nicotinamide, 0.3% panthenol, 1% ferulic acid, 0.5% azelaic acid, 10% 1,2-propanediol, 8% 1, Mix 3-butanediol and 30% deionized water, stir and dissolve evenly at 60-80°C, forming the water phase.

[0045] (2) 10% isopropyl palmitate, 10% caprylic acid / capric triglyceride, 6% soybean lecithin, 0.5% tocopherol, 0.5% menthol, 2% glycerol monostearate were mixed at 60 Stir and dissolve evenly at -80°C, forming an oil phase.

[0046](3) Mix the water phase and the oil phase, stir evenly, and process through a high-pressure homogenizer, the pressure of the high-pressure homogenizer is 90 MPa, and the number of cycles is 4 times to obtain the whitening and freckle-removing liposome.

Embodiment 2

[0048] The preparation method of whitening and freckle removing liposome comprises the following steps:

[0049] (1) 6% arbutin, 4% ascorbyl glucoside, 2% nicotinamide, 0.2% panthenol, 0.5% ferulic acid, 0.5% azelaic acid, 15% glycerin, 6% 1,3-butanediol Alcohol and 30% deionized water are mixed, stirred and dissolved at 60-80°C to form a water phase.

[0050] (2) 5% tocopheryl acetate, 10% caprylic / capric triglyceride, 5% tea seed oil, 4% soybean lecithin, 3% methyl glucose sesquistearate, 1% tocopherol Phenol and 0.3% menthol are mixed, stirred and dissolved at 60-80° C. to form an oil phase.

[0051] (3) Mix the water phase and the oil phase, stir evenly, and process through a high-pressure homogenizer, the pressure of the high-pressure homogenizer is 100 MPa, and the number of cycles is 3 times to obtain the whitening and freckle-removing liposome.

Embodiment 3

[0053] 1. Prepare whitening and freckle-removing skin care milk A according to Table 1, and the dosage and mass fraction of each raw material are shown in Table 2.

[0054] Table 2 Composition of whitening and freckle-removing skin care milk raw materials

[0055]

[0056]

[0057] 2. The preparation method of whitening and freckle-removing skin care milk: mix glyceryl stearate, cetearyl olive oleate, sorbitan olive oil, methylparaben, and phenoxyethanol in Table 2 above, Heat to 85°C, melt and stir evenly, and use it as the oil phase; add the acrylic acid (ester) type / C10-30 alkanol acrylate crosslinked polymer, xanthan gum, carbomer, glyceryl polyether-26 in the formula table 2 , deionized water, heated to 85 ° C, stirred evenly, as the water phase. Add the oil phase and the water phase to the emulsification pot, stir evenly, add the whitening and freckle-removing liposome prepared in Example 1, emulsify and homogenize for 10 minutes, stir and cool to 50°C, add essenc...

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Abstract

The invention discloses a whitening freckle-removing lipidosome and a preparation method and an application of the whitening freckle-removing lipidosome. A whitening freckle-removing lipidosome composition is prepared from 5-30% of whitening and freckle-removing ingredients, 1-40% of polyhydric alcohol, 1-25% of phospholipid, 1-25% of grease, 1-15% of an emulsifying agent and deionized water. Thewhitening and freckle-removing ingredients comprising various components are screened through a large number of experiments, experiment results show that the provided whitening and freckle-removing ingredients have obvious effects on reducing melanogenesis and the like; the various whitening and freckle-removing ingredients are coated by the lecithin, can much easily permeate into the deep layer of the skin as the structures of the lecithin and the lipid structure of the skin are quite similar, and have the advantage of better skin absorption; the whitening and freckle-removing ingredients coated by the lecithin are isolated from the air, so that the problem of oxidation stain is avoided, and the stability is improved. According to a whitening and freckle-removing product prepared by usingthe lipidosome, the whitening and freckle-removing ingredients are slowly released, and the effects of whitening and removing freckles for a long period of time are achieved.

Description

technical field [0001] The invention relates to a whitening and freckle-removing composition, in particular to a whitening and freckle-removing liposome and its preparation method and application. Background technique [0002] The structure of the skin consists of epidermis, dermis and subcutaneous tissue. The epidermis is composed of keratinized stratified squamous epithelium, which is divided into stratum corneum, hyaline layer, granular layer, spinous layer and basal layer from outside to inside. Melanocytes are located in the basal layer of the epidermis. They are spherical cell bodies with different lengths of cell branches - dendrites; the melanin that causes skin discoloration and long spots is produced in melanocytes. The amount and distribution of melanin are the most important factors in determining skin color. The metabolism of melanin is regulated by internal neuro-endocrine factors and influenced by the external environment. When the skin is irradiated by ext...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/60A61K8/55A61K8/42A61K8/365A61K8/362A61K8/34A61K8/14A61Q19/02
CPCA61K8/14A61K8/34A61K8/345A61K8/362A61K8/365A61K8/42A61K8/553A61K8/602A61K8/675A61K8/676A61K8/678A61K2800/56A61Q19/02
Inventor 秦昆明石芸
Owner 连云港本草美汇医药科技有限公司
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