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External plaster for activating blood and relieving pain

A technology for promoting blood circulation and relieving pain, applying plasters, applied in the direction of non-central analgesics, medical preparations with no active ingredients, medical preparations containing active ingredients, etc. and other problems, to achieve the effect of good transdermal absorption, good viscosity, and relieve rheumatism pain

Active Publication Date: 2017-12-15
杭州仁德药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of poor pertinence and unsatisfactory drug efficacy of some plasters, the purpose of the present invention is to provide an external plaster for promoting blood circulation and relieving pain, which has a very obvious effect of eliminating dampness and relieving pain, and has a good transdermal absorption rate and quick effect , the active ingredients in the plaster are not easy to volatilize, the plaster has good viscosity and uniform quality

Method used

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  • External plaster for activating blood and relieving pain
  • External plaster for activating blood and relieving pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] An external plaster for promoting blood circulation and relieving pain, prepared from the following components: borneol 500g, camphor 250g, sustained release agent 150g, Chuanxiong liquid extract 3520g, peppermint oil 150g, cinnamic aldehyde 100g, zinc oxide 1900g, vaseline 150g, rosin 1500g, lanolin 250g, liquid paraffin 50g, skin penetration enhancer 100g, tackifier 60g, emulsifier 60g, dimethyl sulfoxide 50g, rubber 1750g.

[0034] Among them, the Chuanqiongliu extract is prepared through the following process: 500g of Chuanxiong, 500g of rhubarb, 500g of raw aconite, 500g of clove, 500g of Shichangpu, 250g of safflower, 250g of Xu Changqing, 250g of Gansong, 3.5g of musk, and 10g of impatiens. , Buddleia 10g, and Rhizoma Drynariae 20g are mixed and crushed to obtain a coarse powder, then add 95% alcohol for heating and soaking, and vacuum concentrate the soaking solution to 30% of the original volume to obtain Chuanxiong liquid extract.

[0035] The sustained-releas...

Embodiment 2

[0046] An external plaster for promoting blood circulation and relieving pain, prepared from the following components: borneol 625g, camphor 310g, sustained release agent 175g, Chuanxiong fluid extract 4200g, peppermint oil 185g, cinnamic aldehyde 125g, zinc oxide 2375g, vaseline 185g, rosin 1850g, lanolin 310g, liquid paraffin 62.5g, skin penetration accelerator 130g, tackifier 85g, emulsifier 80g, dimethyl sulfoxide 62.5g, rubber 2150g.

[0047] Among them, the Chuanqiongliu extract is prepared through the following process: 625g of Chuanxiong, 625g of rhubarb, 625g of raw aconite, 625g of clove, 625g of Shichangpu, 310g of safflower, 310g of Xu Changqing, 310g of Gansong, 4.25g of musk, and 12.5g of impatiens. g, Buddleia 12.5g, Rhizoma Drynariae 27.5g were mixed and pulverized to obtain a coarse powder, then 95% alcohol was added for heating and impregnating, and the impregnating solution was concentrated in vacuum to 35% of the original volume to obtain Chuanxiong liquid e...

Embodiment 3

[0059] An external plaster for promoting blood circulation and relieving pain, prepared from the following components: borneol 750g, camphor 375g, sustained release agent 200g, Chuanxiong liquid extract 4875g, peppermint oil 225g, cinnamic aldehyde 150g, zinc oxide 2850g, vaseline 225g, rosin 2250g, lanolin 375g, liquid paraffin 75g, skin penetration enhancer 160g, tackifier 110g, emulsifier 100g, dimethyl sulfoxide 75g, rubber 2575g.

[0060] Among them, Chuanqiongliu extract is prepared through the following process: 750g of Chuanxiong, 750g of rhubarb, 750g of raw aconite, 750g of clove, 750g of Shichangpu, 375g of safflower, 375g of Xu Changqing, 375g of Gansong, 5g of musk, 15g of impatiens, Mix 15g of Buddleia and 35g of Rhizoma Rhizoma Rhizoma Rhizoma Drynaria to obtain coarse powder, then add 95% alcohol for heating and impregnation, vacuum concentrate the impregnation solution to 40% of the original volume to obtain Chuanxiong liquid extract.

[0061] Wherein the sust...

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Abstract

The invention belongs to the technical field of plaster preparations. The external plaster for activating blood and relieving pain is prepared from the following raw materials: borneol, camphor, a controlled release formulation, rhizoma chuanxiong liquid extract, peppermint oil, cinnamic aldehyde, zinc oxide, vaseline, rosin, wool fat, liquid paraffin, a transdermal enhancer, a tackifier, an emulsion enhancer, dimethyl sulfoxide and rubber, wherein the controlled release formulation is one of nano-scale cocoanut active charcoal, silane coupling agent modified silica powder or alpha-cyclodextrin. The external plaster for activating blood and relieving pain, disclosed by the invention, has the obvious effects of activating blood and relieving pain, good transdermal absorption ratio and quick effects; effective ingredients in the plaster are slow to volatilize; the plaster is good in viscidity and homogeneous in quality. Meanwhile, in the preparation process, the materials are prepared into nano-scale emulsified slurry and then an adhesive is coated, so that components of the external plaster are more easily absorbed by the skin.

Description

technical field [0001] The invention belongs to the technical field of plaster preparations, in particular to an external plaster for promoting blood circulation and relieving pain. Background technique [0002] Plasters have a long history of application in our country. Vegetable or animal oils are added to make a jelly-like substance, which can be pasted on the affected area for a long time on one side of cloth, paper or leather. The medicine in the plaster is directly applied to the acupuncture points on the body surface. , the property of the medicine permeates the subcutaneous tissue from the surface to the inside through the fur. On the one hand, the relative advantage of the drug concentration is produced locally. So as to exert the greatest systemic pharmacological effect. Traditional injection and oral therapy damage nerves, blood vessels, muscles and other tissues, making it difficult for patients to accept, and these methods are easy to disperse the medicine thro...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61K9/70A61K47/02A61K47/46A61K47/44A61K47/40A61K47/18A61K47/12A61K47/10A61K47/22A61K47/24A61K47/38A61P29/00A61P19/02A61K35/55A61K31/125A61K31/11A61K31/045
CPCA61K9/0002A61K9/7023A61K31/045A61K31/11A61K31/125A61K35/55A61K36/126A61K36/15A61K36/185A61K36/236A61K36/27A61K36/286A61K36/534A61K36/56A61K36/61A61K36/708A61K36/714A61K36/84A61K36/888A61K47/02A61K47/10A61K47/12A61K47/183A61K47/22A61K47/24A61K47/38A61K47/40A61K47/44A61K47/46A61K2236/333A61K2236/51A61K2300/00
Inventor 俞帮和徐明蒋志刚汪海涛
Owner 杭州仁德药业股份有限公司
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