185 results about "Otic Agents" patented technology

Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically but by disparate biochemical pathways. In one embodiment, the transdermal delivery system includes benzyl alcohol and lecithin organogel. The transdermal delivery compositions are used in a variety of topical compositions as a means of transdermally delivering and topically administering different drugs and agents, including compositions promoting collagen biosynthesis, retinoids and skin lighteners, chemical denervation agents such as BOTOX®, anti-fungal agents, anesthetics and non-steroidal anti-inflammatory drugs (NSAIDs). In addition, these topical compositions may be used in combination with non-ablative treatment modalities, such as microdermabrasion, laser-based skin remodeling and radio-frequency-based skin remodeling.

Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian subject, in which the permeabilizing peptide is PN159, PN159 analogues, conjugates of PN159, conjugates of PN159 analogues, or complexes thereof. The permeabilizing agent reversibly enhances mucosal epithelial paracellular transport, typically by modulating epithelial junctional structure and / or physiology at a mucosal epithelial surface in the subject.

The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.

Topically applicable dermatological / cosmetic compositions suited for ungual / peri-ungual administration for the treatment of a variety of pathologies, including fungal pathologies, such as onychomycosis, contain (a) at least one biologically active agent (e.g., antifungal) and (b) at least two of the pro-penetrating agents selected from the group consisting of urea, an organic acid and an ethoxydiglycol, the at least two-pro-penetrating agents respectively being present in effective amounts as to synergistically improve the ungual / peri-ungual bioavailability of the at least one biologically active agent.

Stable, topically applicable, non-greasy and non-tacky oil-in-water (O / W) anti-inflammatory emulsions, useful, e.g., for the treatment of psoriasis, contain: a. a therapeutically effective amount of at least one steroidal anti-inflammatory agent, notably clobetasol propionate; b. a pro-penetrating system which includes at least one pro-penetrating glycol and at least one other pro-penetrating agent; and c. at least one polymeric emulsifier not sensitive to electrolytes, for example not an acrylate / C10-C30 alkyl acrylate copolymer, formulated into a topically applicable, pharmaceutically acceptable vehicle therefor.

The invention discloses a composite antibiotic finishing agent which comprises an organic antibacterial active component, an inorganic antibacterial active component, a penetrating agent, an adhesive, a softening agent, a suspending agent and the balance of water, wherein a non-dissolution type polymer antibacterial agent is selected as the organic antibacterial active component, and silver-loaded nanometer titanium dioxide is selected as the inorganic antibacterial active component. The invention also discloses a method for preparing the composite antibiotic finishing agent and a process used for finishing a mucilage glue and cotton fiber interweaved jacquard fabric. The main material of the composite antibiotic finishing agent for textiles is formed by the organic antibacterial active component and the inorganic antibacterial active component, thus the composite antibiotic finishing agent has a high-efficiency inhibiting capacity of more than 20 kinds of harmful bacteria such as escherichia coli, staphylococcus aureus, gonococcus and the like; the bacteria inhibiting rate is higher than 99 percent; the repelling and preventing rate of dust mites, gamasid mites and chigger is higher than 99 percent; the repelling and preventing rate of dust mites, gamasid mites and chigger is higher than 95 percent, and the killing rate is higher than 90 percent after the mucilage glue and cotton fiber interweaved jacquard fabric is washed for 50 times; and the gonococcus, escherichia coli, staphylococcus aureus and the like do not grow on the fabric which is not washed for 30 times, 50 times or 100 times, and the bacteria inhibiting rate is higher than 99 percent.

The cerebrospinal fluid and intracranial pressure are two major reasons why central nervous system is so vulnerable to injuries. A composition and method for treating injured central nervous tissue, or preventing injury to central nervous system tissue is provided. The composition is comprised of a combination of colloidal osmotic agents and crystal osmotic agents. The method comprise of: a). Withdrawing cerebrospinal fluid from the subarachnoid spaces around the tissue to be treated or protected and b). Injecting the composition which is dissolved by patient's own cerebrospinal fluid into subarachnoid spaces. The treatment can be augmented with agents that suppress production of cerebrospinal fluid, or with other known neuroprotective agents.

The invention aims at providing an antibiotic washing liquid which can carry out sterilization and decontamination simultaneously and a preparation method thereof. The antibiotic washing liquid which can carry out sterilization and decontamination simultaneously composes a double-arc bactericide, a penetrating agent, an emulsifier and a nonionic surfactant, and the sterilization function and the cleaning function are integrated together, therefore the washing and the sterilization can be completed simultaneously. The invention is prepared by fatty alcohol polyoxyethylene ether (7) AEO-7, fatty alcohol polyoxyethylene ether (9) AEO-9, polyhexamethylene biguanidine PHMB, dodecyl dimethyl benzyl ammonium chloride 1227, short-chain fatty alcohol polyoxyethylene ether (8) XL-80, fatty alcohol polyoxyethylene ether (5) AEO-5, lemon essence and deionized water. The preparation method is that the deionized water and the raw materials are added into a material mixing kettle to carry out material mixing, and then the testing, filling, label sticking, inspection and case filling are carried out. The invention adopts the double-arc and double-quaternary ammonium components for composition and can effectively act on pathogenic bacteria, improve bactericidal force and stabilize storage by the function of a specific infiltration promoter; the dosage is saved and the cost performance is high.

The invention provides a disinfectant with low corrosiveness. The disinfectant comprises the following components by weight percent: 0.2-2.0% of ortho-phthalaldehyde, 1-10% of a synergist, 10-50% of a cosolvent, 0.5-5% of a buffering agent, 1-10% of a penetrant, 0.2-2% of a corrosion inhibitor, 0.1-5% of a chelating agent, 0.1-3% of a stabilizing agent and 45-80% of purified water. After the disinfectant is used, intestinal tract pathogenic bacteria, pyogenic coccus, hepatitis virus, H7N9 avian influenza virus, black variant spores of bacillus subtilis and other pathogenic microorganisms can be killed within a short time. Furthermore, the disinfectant adopts a slow release technique, thus having extremely low corrosiveness on metal and being very suitable for disinfecting medical equipment.

The use of L-carnitine and its alkanoyl devivatives, optionally in the form of a pharmaceutically acceptable salt, as osmotic agents in the preparation of solutions for medical use, particularly for peritoneal dialysis, is described.

The invention discloses a disease treatment agent for fruit tree and forest tree limb, and is composed of the following compositions by mass percent: 0.5-5% of tebuconazole, 1-30% of thiophanate methyl, 1-3% of dispersant, 1-3% of wetting agent, 1-4%of antifreezing agent, 3-20% of film forming agent polyvinyl alcohol, 0.1-2.0% of colouring agent methylrosanilinium chloride, 0.5-2%of osmotic agent, 0.002-0.008% of plant growth regulation hormone naphthylacetic acid, 0.0002-0.002% of gibberellin, and 40-90% of water. The invention solves the problems of large preparation residual toxicity, short drug effect stage, slow healing, easy relapse or the like, and is used as a new medicament for protection, treatment and promoting plant growth.

The invention belongs to the technical field of chemical preparations and in particular relates to a catching agent of benzene series compounds and a preparation method thereof. The catching agent of the benzene series compounds comprises the following raw materials in parts by weight: 5-8 parts of polyacrylamide, 10-20 parts of starch, 8-15 parts of sorbic acid, 10-15 parts of sodium sorbate, 30-45 parts of plant flower extractive, 5-10 parts of penetrating agent, 15-20 parts of sepiolite powder, 1-3 parts of cerium manganese compound oxide catalyst, 5-10 parts of cross-linked rectorite, 10-20 parts of chitosan and 80-100 parts of deionized water. The catching agent of the benzene series compounds is good in absorption and long in service life, so that the pollution caused by the benzene series compounds after decoration of a house is solved; meanwhile, the catching agent of the benzene series compounds is also capable of effectively inhibiting or killing some bacteria and viruses in influenza, intestinal tract and skin; the catching agent of the benzene series compounds is beneficial to the health of people.

The invention provides anti-mosquito cloth, which is prepared after an anti-mosquito medicament is attached to cloth to be dried. The anti-mosquito medicament is formed by mixing an anti-mosquito liquid medicament and accessory ingredient solution which at least comprises a penetrating agent and a sustained release agent, wherein the mass volume concentration and the volume ratio of each composition are that: the anti-mosquito liquid medicament has over 60 percent of medicinal mass volume concentration of the liquid medicament body, and accounts for 10 to 20 percent of the anti-mosquito medicament by volume; the accessory ingredient solution accounts for 80 to 90 percent in the anti-mosquito medicament by volume; the accessory ingredient solution at least comprises the following compositions in mass volume concentration by percentage: 0.1 to 2.9 percent of the penetrating agent, and 3.7 to 11.3 percent of the sustained release agent; and the sum of the volume percentages of all components of the anti-mosquito medicament is 100 percent. The anti-mosquito liquid medicament can quickly penetrate clearances among the cloth to form excellent pull-out capacity, good washability and sustained anti-mosquito effect.

A topical oil-in-water composition of ivermectin is provided. The topical oil-in-water composition contains an oily phase, an aqueous phase and a surfactant emulsifier. The emulsion is essentially devoid of any solvents or propenetrating agents for ivermectin and any gelling agent.

The invention discloses a deodorization composition and application thereof. The deodorization composition contains an amino acid complex of (9Z,12R)-12-hydroxy-octadecanoic acid zinc salt and / or copper salt, paraformaldehyde and / or 3-methoxy-4-hydroxybenzaldehyde, a stabilizer, a penetrant, an antibacterial agent and an antistatic agent, wherein the weight ratio of the components is 1:(0.1-4.0):(0.05-0.5):(0.05-0.5):(0.001-0.2):(0.001-0.2). A method for removing foul odor, provided by the invention, comprises contacting an aqueous solution containing the deodorization composition with the foul odor. The deodorization composition disclosed by the invention can meet green and environment-friendly requirements, and can be applicable to elimination of off-odors of ammonium, hydrogen sulfide, methyl mercaptan, dimethyl sulfide and the like. The deodorization composition disclosed by the invention can effectively relieve the problem of pollution of the off-odors to the environment, has an excellent deodorization performance, is small in dosage, is simple in treatment process and obvious in effect, and is easy to promote and apply.

The invention relates to preparation for a pinus koraiensis phytoncide finishing agent, a fabric finished by same and a finishing method thereof. The formula of the finishing agent contains 10-40g / L of pinus koraiensis phytoncide microcapsule, 10-35g / L of chitosan cross-linking agent, 2-5g / L of organic silicon soft finishing agent and 1-3g / L of penetrant. The pinus koraiensis phytoncide finishing agent is prepared according to the steps of extracting pinus koraiensis phytoncide, preparing the pinus koraiensis phytoncide microcapsule, preparing the pinus koraiensis phytoncide finishing agent, bottling and packaging. The finishing agent is applied to the finishing of the cotton fabric. The cotton fabric has the antibacterial rate for staphylococcus aureus of above 98.2%, antibacterial rate for escherichia coli of above 92.3%, antibacterial rate for candida albicans of above 90.5%, deodorization rate of above 97.2%, mite-proof rate of above 90.6% and the reducing rate of sterilizing, deodorizing and mite-proof effects of below 10% after being cleaned for more than 20 times.

The present invention provides a pesticide formulation that is effective, non-persistent in the environment, and meets the criteria for use in organic food production as set for the by the United States Department of Agriculture (USDA) and Organic Materials Review Institute (OMRI). The formulation may be used for the control and eradication of pathogens such as germs and viruses, insects, insect larvae, mold, slime and fungus, and algae. The compositions provide a formulation containing an oxidizing compound in conjunction with a botanically derived surfactant / membrane permeablization agent. The formulation typically contains a hydrogen peroxide generating compound(s) and saponin glycoside compounds, which, in combination, show enhanced activity towards insects, pathogens algae, slime, mold and fungus. The method is exemplified by applying an effective amount of a composition containing an aqueous mixture of hydrogen peroxide and surface-active saponin botanical extracts preferentially derived from Quillaja saponaria and / or Yucca schidigera, to water bodies, surfaces, and in or on turf. The composition is also effective for control of odors and sulfurous black layer found in turf.

The invention relates to an antifungal and antibacterial agent for a waterproof leather product and a preparation method of the antifungal and antibacterial agent. The antifungal and antibacterial agent for the waterproof leather product comprises the following components in percentage by weight: 1-6.5 percent of antifungal agent, 2-5 percent of antibacterial agent, 1-4 percent of penetrating agent, 1-4 percent of dispersion emulsion, 1-3 percent of thickening agent, 2-5 percent of anti-freezing agent, 0.05-0.1 percent of antifoaming agent and the balance of solvent. By adopting the antifungal and antibacterial agent for the waterproof leather product and the preparation method of the antifungal and antibacterial agent, provided by the invention, an efficient, low-toxicity, convenient (soaking, padding or direct spraying), water soaking-resistant and water washing-resistant antifungal effect can be achieved. In the antifungal and antibacterial agent for the waterproof leather product, a grafted quaternary ammonium salt cation antibacterial agent is added and can be organically combined with the leather product for forming a layer of antibacterial film on the surface of the leather product, so that an excellent water-resistant antibacterial effect is achieved.

The invention relates to the technical field of non-woven fabric production and application, in particular to an antibacterial finishing agent as well as an antibacterial all-cotton spunlace non-wovenfabric and a product thereof. The antibacterial finishing agent comprises organosilicon quaternary ammonium salt and a penetrant. The antibacterial all-cotton spunlace non-woven fabric comprises thefollowing preparation steps of 1, mixing the antibacterial finishing agent and water and uniformly stirring to prepare an antibacterial finishing liquid; and 2, performing antibacterial finishing on cloth by adopting the antibacterial finishing liquid; preforming drying treatment on the finished cloth, and finally winding to obtain the antibacterial all-cotton spunlace non-woven fabric. The non-woven fabric has good hydrophilic performance and does not damage the beneficial flora on the surface of a human body.

A hydrophilic liquid disinfectant for surgical operation, trauma, burn, perineal mucosa, oral mucosa, vaginal mucosa, etc is prepared through adding iodine, chlorhexidine and polyhexamthylene guanidine to non-ionic surfactant, heating, stirring, adding penetrant, phosphoric acid and water, and stirring.

The invention provides a cleaning-free compound hand sanitizer. The cleaning-free compound hand sanitizer is characterized by comprising the following components by mass-to-volume ratio: 0.45-0.55% of chlorhexidine, 0.05-0.15% of triclosan, 0.12-12% of Chinese herb extract compound, 50-60% of alcohols, 0.1-3% of nonionic surfactant, 0.5-2% of penetrant, and the balance of water. The cleaning-free compound hand sanitizer is stable in performance, broad-spectrum antibacterial, fast in sterilization, free of gooey feeling after hands are washed, good in moisturizing effect, mild in odor, and free of stimulation. The invention also discloses a preparation method of the cleaning-free compound hand sanitizer. The preparation method is simple and applicable to large-scale production and application.

Compositions for inducing a natural tan of the skin is disclosed. The compositions contain D-ribose as the active ingredient plus a penetrant to deliver D-ribose to the basal cells and dermis of the skin. Compositions further containing emollients and emulsifiers are preferred.

The invention provides an anti-crease and anti-microbial clothing finishing agent and an application method thereof. The anti-crease and anti-microbial clothing finishing agent comprises 5 to 8 parts of Blumea oil, 25 to 35 parts of chitosan, 55 to 65 parts of water-based polyurethane, 12 to 18 parts of a softening agent, 3 to 6 parts of a penetrating agent JFC and 2 to 8 parts of a catalyzer. The anti-crease and anti-microbial clothing finishing agent provided by the invention can be used for treating natural fiber and synthetic fiber fabrics as well as natural fiber and synthetic fiber blended fabric clothing, can improve the anti-crease performance of the clothing, and can further improve the biodegradability of the fabric. The clothing is soaked into the finishing agent, then pressed until the liquid take-up rate reaches 55 to 70 percent, preheated in a heat-setting machine, and then baked. The wrinkle recovery angles, in the warp direction and in the weft direction, of treated clothing are 200 to 220 degrees, the growth of staphylococcus aureus and escherichia coli is restrained remarkably, and the anti-crease and anti-microbial clothing finishing agent has an antibacterial property, and remarkable economic benefit and environmental benefit.

The invention belongs to the technical field of insecticides characterized by surfactants, and specifically relates to an acaricide, wherein the acaricide is prepared from a surfactant and a penetrant. The acaricide has the advantages of good fast-acting property, long expiry date, safety and environmental friendliness, high safety and wide application range, and can be applied to agriculture-forestry mites as well as medical-animal husbandry mites and high safety of acaricidal effect without or with little residue; moreover, the acaricide is convenient to use and can be used independently ordirectly added into other drugs.

The invention relates to a bactericidal composition with active ingredients to be pyrazole-kresoxim-methyl and thiram, and belongs to the bactericidal composition pesticide technology field. The bactericidal composition contains the active ingredients to be the pyrazole-kresoxim-methyl and the thiram, the weight ratio of which are 1:40-40:1 and the weight percentages are 1%-90%; and the bactericidal composition can be prepared into wettable powder, water dispersible granules, a suspending agent, aqueous emulsion, micro-emulsion, or other formulations. The bactericidal composition at least contains a carrier and an accessory ingredient, wherein at least one is a surface active agent which can be an emulsifier, a dispersant, a humectant or a penetrant. The carrier can be water, organic solvent or latent solvent, and filling material according to the different preparation formulations. A stabilizing agent, a thickening agent, a defoaming agent, a cementing agent and other functional accessory ingredients can be added when necessary. The bactericidal composition can be used for preventing and curing a plurality of plant diseases caused by oomycetes, ascomycetes, basidiomycetes, deuteromycetes, and so on, so as to play an important role in enhancing effects, curing diseases, reducing cost, delaying pesticide resistance, etc.

The invention discloses a compound disinfectant for circulating water systems, comprising benzyltribenzyl phosphonium chloride, dithiocyano-methane and copper sulfate. When the compound disinfectant is used, if certain amount of penetrant is added, the synergistic effect among drugs can be brought into full play, and not only the antibacterial activity can be effectively improved but also microorganisms can be avoided from generating resistance to drugs due to long-term use of single variety of disinfectants. The compound disinfectant of the invention has good disinfection and algae elimination effects and low use cost, simultaneously solves the problem of resistance of bacteria to common disinfectants and is suitable for circulating cooling water systems, reclaimed water circulating systems, clean drainage recycling systems or other circulating water systems.

The present invention belongs to the field of medicine technology, and is especially oral loratadine disintegrating tablet for treating allergic diseases and its preparation process. The oral loratadine disintegrating tablet includes loratadine as effective medicine component, and excipient mixture comprising disintegrating agent, stuffing, soluble polyol and penetrant. The oral loratadine disintegrating tablet consists of loratadine 20-50 wt%, disintegrating agent 5-15 wt%, stuffing 10-30 wt%, soluble polyol 30-60 wt%, and penetrant 1-5 wt%. The oral loratadine disintegrating tablet, after being disintegrated fast, can cover gastrointestinal mucous membrane widely, and has fast acting, no first pass effect, high bioavailability, and convenient taking.

The invention belongs to the technical field of pesticides and discloses a wettable powder containing fluroxypyr, florasulam and carfentrazone-ethyl. The compounded wettable powder is prepared with the fluroxypyr, the florasulam and the carfentrazone-ethyl as main active components according to the mass ratio of 0.1-60:0.1-40:0.1-80. The total mass percentage content of the fluroxypyr, the florasulam and the carfentrazone-ethyl in the wettable powder is 1-90%. The aqueous agent also includes 1-20% of a dispersing agent, 1-10% of a wetting agent, 0-10% of a speader, 0-15% of a permeating agent and the balanced being filling materials. The wettable powder is safe and convenient to store and transport. By means of combination of the herbicides, the wettable powder is enlarged in weeding spectrum and is improved in weeding effect. The wettable powder is wide in the weeding spectrum, is quick in effects, is long in lasting period, can delay the drug resistance, is complete in weeding, is low in residue, is low in toxicity and is safe and environmental-protective. The wettable powder is an excellent chemical herbicide.