Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
47 results about "Corynebacterium diphtheriae" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Corynebacterium diphtheriae is the pathogenic bacterium that causes diphtheria. It is also known as the Klebs-Löffler bacillus, because it was discovered in 1884 by German bacteriologists Edwin Klebs (1834–1912) and Friedrich Löffler (1852–1915).
Combination vaccine
InactiveUS20090130146A1Effective seroprotectionGood immune protectionAntibacterial agentsBacterial antigen ingredientsBacteroidesDisease
The present invention relates to the combination of antigens directed against bacteria and viruses, their uses and the preparation of medicaments in order to confer protection against infectious diseases. In particular, the invention relates to a combination vaccine comprising at least one antigen of Clostridium tetani, at least one antigen from Corynebacterium diphtheriae, and at least one antigen from the TBE-flavivirus suitable to confer seroprotection against diseases and medical conditions caused by these pathogenic organisms.
Owner:NOVARTIS AG
Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
ActiveUS20130122040A1Minimising and avoiding cross-linkingLower potentialAntibacterial agentsBacterial antigen ingredientsDetoxification ProcessDiptheria toxoid
The present invention relates to a fermentation medium for cultivating Corynebacterium diphtheriae. The present invention also relates to the use of the fermentation medium in processes for obtaining diphtheria toxin from the Corynebacterium diphtheriae bacteria being cultivated and the preparation of vaccines using the diphtheria toxin obtained in the processes. The present invention further relates to a purification and detoxification processes specifically adapted for preparing a diphtheria toxoid for inclusion into a vaccine.
Owner:GLAXOSMITHKLINE BIOLOGICALS SA
Cool moistening type herbal tea and preparation method thereof
InactiveCN102972578ASweating and antipyretic effect hasImprove cycle performanceTea substituesLicorice rootsSweat gland
The invention relates to a cool moistening type herbal tea and a preparation method thereof. The cool moistening type herbal tea comprises the following raw materials, by weight, 10-60 parts of Chinese mesona herb, 10-40 parts of chrysanthemum, 0-5 parts of honeysuckle, 0-5 parts of mulberry leaf, 10 parts of japanese pogodatree flower, 2 parts of lotus leaf, 10 parts of dandelion, 4 parts of licorice root, and 10 parts of obtuseleaf senna seed. The cool moistening type herbal tea has the following beneficial effects that: with the raw materials, a heat clearing detoxification effect is provided, wherein the honeysuckle and the like provide the heat clearing detoxification effect; a diaphoresis fever relieving effect is provided, wherein the effect is achieved by regulating temperature center; a body surface blood circulation enhancement effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs can provide effects of peripheral vessel expanding, body surface blood circulation enhancement and sweat gland secretion promoting so as to increase heat dissipating during aversion to cold; an antibacterial and antivirus effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs provide inhibition or killing effects for a lot of bacteria, viruses and other pathogenic microorganisms; the dandelion provides effects of wind-evil dispelling, fever relieving, dieresis and swelling subsiding; and the chrysanthemum provides inhibition effects for a lot of gram-positive bacteria, gram-negative bacteria and corynebacterium diphtheriae.
Owner:陈楚忠
Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
ActiveUS9040058B2Speeding drying processAntibacterial agentsBacterial antigen ingredientsMicrobiologyDiptheria toxoid
Owner:GLAXOSMITHKLINE BIOLOGICALS SA
Preparation method of diphtheria vaccine
ActiveCN104027797AHigh purityImprove controllabilityAntibacterial agentsBacterial antigen ingredientsFiltrationUltrafiltration
The invention provides a preparation method of a diphtheria vaccine and aims at solving the problems of long production period of the diphtheria vaccine, ammonium sulfate pollution generated in production process, excessive impurity protein in the final product and over-large side reaction of the product in the prior art. The preparation method of the diphtheria vaccine is characterized by comprising the following steps of 1) carrying out resuscitation and fermentation cultivation of a corynebacterium diphtheriae strain, thereby preparing a diphtheria bacterial solution; 2) centrifuging the diphtheria bacterial solution, carrying out triple filtration treatment, and then carrying out ultrafiltration concentration, and dialysis and elution, thereby obtaining a diphtheria toxin; 3) detoxifying the diphtheria toxin, and then carrying out ultrafiltration concentration, and dialysis and elution by use of a tangential flow ultrafiltration system; 4) purifying the detoxified diphtheria toxin. High-speed centrifuging is used for removing bacteria, and ultrafiltration concentration and elution are used instead of adsorption by use of active carbon and salting out by use of ammonium sulfate, and the whole experimental steps can be finished by only one day, and therefore, the process steps are simplified, the production period is shortened, the production efficiency is improved and the controllability of the operation steps is improved.
Owner:SHANDONG YIDU BIOTECH
Medicament combination preparation of medicinal compound containing cy-ethyl razepam
The invention relates to medicament combination preparation of medicinal compound taking cy-ethyl razepam medicinal compound containing cy-ethyl razepam or stereoisomer, pro-medicinal, medicinal salt, complex salt or / and salvation as effective constituent. The medicament combination preparation adopts the technical scheme that the cy-ethyl razepam medicinal compound, which has a general formula (1) structure and contains the cy-ethyl razepam or the stereoisomer, the pro-medicinal, the medicinal salt, the complex salt and the solvation, is taken as the effective constituent and forms the medicament combination preparation with a medicament carrier capable of being received on the pharmacy; and the preparation formulation is any preparation formulation said on the pharmacy. The invention also discloses an application of the medicament combination preparation in the process of treating the infection of bacteria taken as gram-positive bacteria like staphylococcus, pneumococcus, enterococcus faecalis, streptococcus, streptococcus bovis, streptococcus pneumoniae, peptostreptococcus, festering streptococcus pneumoniae, festering streptococcus pneumoniae, streptococcus pyogenes, streptococcus agalactiae, viridans streptococci, streptococcus bovis, streptococcus agalactiae B, group green streptococcus, corynebacterium diphtheriae and other bacteria.
Owner:LIAONING LIFENG SCI & TECH DEV
Henhouse disinfectant formula
InactiveCN105519605ANo drug resistanceImprove disinfection abilityBiocideDead animal preservationDisinfectantStaphylococcus aureus
The invention discloses a henhouse disinfectant formula which consists of the following raw materials in parts by weight: 5-10% of an onion original liquid, 5-10% of a sanguisorba officinalis extract liquid, 0.5-1% of hexachlorophene, 1-3% of formalin with the formaldehyde content of 40%, 0.5-1% of sodium dichloroisocyanurate, and 0.01%-0.02% of an additive named 'Chuqin'an' according to the Chinese pronunciation; a henhouse disinfectant is prepared by mixing and stirring evenly the raw materials according to the proportion. The onion original liquid and the sanguisorba officinalis extract liquid are used as the main raw materials of the disinfectant, the onion original liquid has the effect of killing staphylococcus aureus, corynebacterium diphtheriae and the like, the sanguisorba officinalis extract liquid can kill various strains of typhoid fever or paratyphoid fever pathogens and shigella dysenteriae in one minute, and the two components cooperate with a chemical disinfectant, so that the disinfectant cannot make pathogenic bacteria generate the drug resistance and has strong disinfection effect and the like.
Owner:铜陵润生生态养殖有限公司
Combination heptavalent vaccine
ActiveUS20130280293A1Reduce in quantityImprove satisfactionBacterial antigen ingredientsSsRNA viruses positive-senseClostridium tetaniImmunogenicity
The invention provides a stable immunogenic composition for prevention and prophylaxis of infections caused by rota virus, poliomyelitis virus, Haemophilius influenza, Hepatitis B, Corynebacterium diphtheriae, Clostridium tetani, Bordatella pertusis (acellular) in a single combined vaccine. The invention also provides for a bivalent immunogenic composition against rota virus and polio virus. The process of making such compositions of the multivalent antigens are also disclosed. The present invention also relates to the production and use of such vaccines for prophylaxis against the infections mentioned above.
Owner:BHARAT BIOTECH INTERNATIONAL
Expression vector stably replicated in corynebacterium diphtheriae and corynebacterium diphtheriae with expression vector
InactiveCN102766647AHigh yieldHigh expressionBacteriaMicroorganism based processesA-DNASecretory protein
The invention discloses an expression vector stably replicated in corynebacterium diphtheriae and corynebacterium diphtheriae with the expression vector. The expression vector comprises a replication origin DNA (deoxyribonucleic acid) sequence stably replicated in the corynebacterium diphtheriae, a DNA (deoxyribonucleic acid) sequence capable of expressing a peptide-mediated protein sequence and a DNA (deoxyribonucleic acid) sequence of a CRM197 recombinant protein coding gene; the expression vector stably replicated in the corynebacterium diphtheriae carried by the corynebacterium diphtheriae has the replication origin DNA (deoxyribonucleic acid) sequence stably replicated in the corynebacterium diphtheriae so that the expression vector is stably replicated in the corynebacterium diphtheriae; meanwhile, by the DNA (deoxyribonucleic acid) sequence capable of expressing the peptide-mediated protein sequence on the expression vector, the expressed CRM197 recombinant proteins carry out the secretory expression and secretes extracellularly so as to increase the expression quantity of the CRM 197 recombinant proteins; the purification process of the expressed CRM197 recombinant proteins is further simplified; the yield of the proteins is increased; and, the production time and the production cost are saved.
Owner:CANSINO BIOLOGICS INC
Drug composition for treating red skin disease of grass carp and preparation method of drug composition
ActiveCN103432364ARetain activityIncrease contentAntibacterial agentsPlant ingredientsBiotechnologyBacterium herbicola
The invention discloses a drug composition for treating red skin disease of grass carp. The drug composition comprises the following traditional Chinese medicine in parts by weight: 10 to 30 parts of humulus japonicus, 20 to 30 parts of euphorbia humifusa, 2 to 10 parts of melia azedarach leaves, 20 to 25 parts of herba houttuyniae, 2 to 10 parts of hinoki leaves and 2 to 7 parts of garlic. The invention further discloses a preparation method of the drug composition. According to the drug composition for treating red skin disease of the grass carp, the effective constituents of lupulone and humulone in the humulus japonicus have obvious inhibiting effects on gram positive bacteria such as staphylococcus aureus, streptococcus faecalis, streptococcus pneumoniae, corynebacterium diphtheriae, bacillus anthracis, bacillus subtilis and bacillus cereus in vitro. In the preparation method, a supercritical CO2 extraction method is adopted to extract effective constituents from humulus japonicus, so that activity of the effective constituents of the humulus japonicus is reserved, and the content is higher. The preparation method provided by the invention is simple and practical, and is suitable for large-scale production.
Owner:泰州市春达动物药业饲料有限公司
Vaccine for inducing an improved immune reaction
ActiveUS20130273101A1Efficient preparationGood effectAntibacterial agentsSsRNA viruses negative-senseHepatitis B virusNeisseria meningitidis
The present invention relates to a pharmaceutical vaccine composition comprising: (a) a pathogen-derived antigen selected from the group consisting of Mycobacterium tuberculosis antigen, Bacillus anthracis antigen, HAV (hepatitis A virus) antigen, HBV (hepatitis B virus) antigen, HCV (hepatitis C virus) antigen, HIV (human immunodeficiency virus) antigen, influenza virus antigen, HSV (herpes simplex virus) antigen, Hib (Haemophilus influenzae type b) antigen, Neisseria meningitidis antigen, Corynebacterium diphtheriae antigen, Bordetella pertussis antigen, Clostridium tetani antigen and Varicella virus antigen; (b) a deacylated non-toxic LOS (lipooligosaccharide); and (c) a pharmaceutically acceptable carrier.
Owner:EYEGENE INC
Composition of yeast fermentation extract
PendingCN113116759AImprove immunityReduce stimulationCosmetic preparationsAntipyreticBiotechnologyChlorogenic acid
The invention discloses a composition of a yeast fermentation extract. The composition is prepared from the following raw materials in parts by weight: 5-6 parts of the yeast fermentation extract, 1.3-2.6 parts of hyaluronic acid, 15-25 parts of vaseline, 1.3-4.8 parts of carboxymethyl chitosan, 0.7-2.6 parts of arbutin, 0.1-0.2 part of a preservative synergist and 60-80 parts of deionized water. By utilizing a mixture of the taraxacum mongolicum, flos chrysanthemi indici, flos lonicerae, coptis chinensis and folium phyllostachys, a fermentation product contains a large amount of chlorogenic acid and total flavonoids in the whole herb, has an inhibition effect on staphylococcus aureus, hemolytic streptococcus, pneumococcus, corynebacterium diphtheriae and other bacteria and common pathogenic dermatophyte, can improve the immunity of the organism, and has oxidation resistance; and meanwhile, the composition can quickly remove subcutaneous free radicals, has a good anti-wrinkle effect, can relieve irritation and inflammatory injury, caused by superoxide free radicals, to skin tissues, obviously relieve acne symptoms, and accelerate repair of skin lesion parts and focuses.
Owner:广州市万千粉丝化妆品有限公司
Application of corynebacterium diphtheroid as immune adjuvant in poultry oil emulsion inactivated vaccine
InactiveCN107684621AReduce pollutionReduce lossPharmaceutical non-active ingredientsEmulsion deliveryBiological propertyOil emulsion
The invention discloses application of corynebacterium diphtheroid as an immune adjuvant in a poultry oil emulsion inactivated vaccine. The corynebacterium diphtheroid refers to the corynebacterium similar to corynebacterium diphtheriae in respect of morphological and biological characteristics, namely the low-pathogenic or non-pathogenic corynebacterium except the high-pathogenic corynebacteriumdiphtheriae. The corynebacterium diphtheroid active adjuvant disclosed by the invention has high immunity stimulation activity and can be used for non-specifically stimulating the immune functions ofT and B lymphocytes so as to promote secretion of a plurality of cytokines; by adding the immune adjuvant into the poultry oil emulsion inactivated vaccine, the vaccine induced generation of animal antibody can be obviously promoted.
Owner:SOUTH CHINA AGRI UNIV +1
An improved process of conjugation and novel synthetic oligosaccharide- protein conjugates obtained thereof
InactiveUS20170246313A1High yieldHigh purityAntibacterial agentsBacterial antigen ingredientsSalmonella serotype typhiTetanus toxoids
The present invention relates to an improved process of conjugation to obtain synthetic oligosaccharide-protein (OS-PR) conjugates. The process of synthetic OS-PR conjugation is a rapid process providing oligosaccharide-protein conjugates which are highly immunogenic and elicit specific and homogenous immune responses. The synthetic oligosaccharide comprising of four to eight repeating units of respective monomers and at least one in-built terminal amino linker, said synthetic polysaccharide mimics natural polysaccharide obtained from gram negative bacteria such as Neisseria meningitidis serogroups A, C, Y, W, X and Haemophilus influenzae and carrier protein is obtained from gram positive bacteria such as Clostridium tetani (tetanus toxoid) or Corynebacterium diphtheriae (CRM197) or their recombinant versions. The conjugation chemistry of the said oligosaccharide-protein conjugate of the present invention is thio-ether linkage. The present invention takes complete process time in the range of 14-22 hours. The said oligosaccharide-protein conjugates are useful in production of monovalent vaccine or multivalent combination vaccines and as diagnostic tool.
Owner:MSD WELLCOME TRUST HILLEMAN LAB PVT LTD
Cool moistening type herbal tea and preparation method thereof
InactiveCN102972575ASweating and antipyretic effect hasImprove cycle performanceTea substituesLicorice rootsBlood vessel
The invention relates to a cool moistening type herbal tea and a preparation method thereof. The cool moistening type herbal tea comprises the following raw materials, by weight, 10-60 parts of Chinese mesona herb, 10-40 parts of chrysanthemum, 0-5 parts of honeysuckle, 0-5 parts of mulberry leaf, 10 parts of seasoned orange peel, 2 parts of lotus leaf, 10 parts of dandelion, 4 parts of licorice root, and 10 parts of figwort. The cool moistening type herbal tea has the following beneficial effects that: with the raw materials, a heat clearing detoxification effect is provided, wherein the honeysuckle and the like provide the heat clearing detoxification effect; a diaphoresis fever relieving effect is provided, wherein the effect is achieved by regulating temperature center; a body surface blood circulation enhancement effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs can provide effects of peripheral vessel expanding, body surface blood circulation enhancement and sweat gland secretion promoting so as to increase heat dissipating during aversion to cold; an antibacterial and antivirus effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs provide inhibition or killing effects for a lot of bacteria, viruses and other pathogenic microorganisms; the dandelion provides effects of wind-evil dispelling, fever relieving, dieresis and swelling subsiding; and the chrysanthemum provides inhibition effects for a lot of gram-positive bacteria, gram-negative bacteria and corynebacterium diphtheriae.
Owner:陈楚忠
Wormwood micropowder composite acrylic fiber polymer material fiber and preparation method thereof
InactiveCN110241478AConjugated synthetic polymer artificial filamentsArtifical filament manufacturePolymer scienceMoisture regain
The invention provides a preparation method of a wormwood micropowder composite acrylic fiber polymer material fiber. The method comprises the steps of preparation of a modified polyacrylonitrile spinning solution and preparation, blending and spinning forming of wormwood micropowder. According to the wormwood micropowder composite acrylic fiber polymer material fiber, the breaking strength is 7.66-8.24 cN / dtex, the elongation at break is 56.8-59.2%, the breaking strength after 800-hour solarization is 7.12-7.95 cN / dtex, the rebound rate when the fiber is elongated by 20% is 82.5-94.0%, and the dry wear-resisting number is 1998-2011. The fiber has different degrees of inhibition effect on aspergillus niger, gold alpha-hemolytic streptococcus, diplococcus pneumoniae, corynebacterium diphtheriae, sonne bacillus, typhoid and paratyphoid bacillus, vibrio cholerae and the like; the moisture regain rate of a fabric prepared from the fiber is 1.98-2.01%, and the anti-pilling level of the fabric is higher than level 4.
Owner:ZHONGKE TEXTILE RES INST QINGDAO CO LTD
Cool moistening type herbal tea and preparation method thereof
InactiveCN102972577ASweating and antipyretic effect hasImprove cycle performanceTea substituesLicorice rootsRaw material
The invention relates to a cool moistening type herbal tea and a preparation method thereof. The cool moistening type herbal tea comprises the following raw materials, by weight, 10-60 parts of Chinese mesona herb, 10-40 parts of chrysanthemum, 0-5 parts of honeysuckle, 0-5 parts of mulberry leaf, 10 parts of ginseng leaf, 2 parts of lotus leaf, 10 parts of dandelion, 4 parts of licorice root, and 10 parts of figwort. The cool moistening type herbal tea has the following beneficial effects that: with the raw materials, a heat clearing detoxification effect is provided, wherein the honeysuckle and the like provide the heat clearing detoxification effect; a diaphoresis fever relieving effect is provided, wherein the effect is achieved by regulating temperature center; a body surface blood circulation enhancement effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs can provide effects of peripheral vessel expanding, body surface blood circulation enhancement and sweat gland secretion promoting so as to increase heat dissipating during aversion to cold; an antibacterial and antivirus effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs provide inhibition or killing effects for a lot of bacteria, viruses and other pathogenic microorganisms; the dandelion provides effects of wind-evil dispelling, fever relieving, dieresis and swelling subsiding; and the chrysanthemum provides inhibition effects for a lot of gram-positive bacteria, gram-negative bacteria and corynebacterium diphtheriae.
Owner:陈楚忠
Skin antibacterial liquid and preparation method thereof
InactiveCN112353897AAvoid infectionEasy to solve skin problemsAntibacterial agentsAntimycoticsDiseaseBaical Skullcap Root
The invention discloses a skin antibacterial liquid. The skin antibacterial liquid comprises the following raw materials in parts by weight, 16.13-3.22 parts of perfoliote knotweed herb, 5.33-1.06 parts of baical skullcap root, 5.38-1.09 parts of coptis root, 6.45-1.29 parts of amur corktree bark, 10.75-2.15 parts of astragalus root, 3.23-0.65 parts of divaricate saposhnikovia root, 2.15-0.43 parts of Artemisia argyi, 1.09-0.22 parts of Eucalyptus, 4.3-0.86 parts of honeysuckle, 3.23-0.65 parts of licorice and 1.09-0.22 parts of borneol. Through the mutual effect of pure traditional Chinese medicine extraction and excellent formula traditional Chinese medicinal materials, the traditional Chinese medicine composition has obvious curative effects on burns and scalds, skin ulcer, acne, urticaria, herpes zoster, eczema, pustule and the like, and also has multiple curative effects on more than thirty skin diseases such as prickly heat, Hong Kong feet, skin itch and allergic skin diseases; the traditional Chinese medicine composition can be used for preventing a patient from being repeatedly infected by bacteria and conveniently solving the skin problem of the patient, has different degrees of bacteriostatic action on staphylococcus aureus, diplococcus pneumoniae, streptococcus deep haemolyticus, corynebacterium diphtheriae, pseudomonas aeruginosa and bacillus anthracis, effectivelyimproves the effects of sterilization, bacteriostasis, inflammation resistance and allergy resistance, improves the treatment effect and is convenient to use.
Owner:山东瑞和药业有限公司
Essential oil composition and preparation method thereof
The invention provides an essential oil composition and a preparation method thereof. Clove essential oil, sandalwood essential oil, eucalyptus essential oil, citronella essential oil and chamomile essential oil are compounded according to a scientific ratio, so that the essential oil composition can emit pleasant fragrance, effectively improve the air quality, remove peculiar smell and inhibit pathogenic bacteria in air, ad especially has good inhibition effect on escherichia coli, hemolytic coccus and corynebacterium diphtheriae; bamboo juice, plumeria rubra and shaddock peel are added to improve the action effect and the action time of the essential oil for inhibiting bacteria and removing peculiar smell; and rhamnolipid, propolis and phytosphingosine are combined, so that the stability of the essential oil component can be further improved, and the action time can be prolonged. The essential oil composition does not contain components harmful to human bodies, and is high in safety and free of irritation.
Owner:宁波风谷环保科技有限公司
Mosquito repellent spray for livestock and poultry and application of mosquito repellent spray
InactiveCN111529655AHas a bactericidal effectHas antibacterial propertiesBiocideHydroxy compound active ingredientsBiotechnologyBacillus typhosus
The invention provides a mosquito repellent spray for livestock and poultry. The mosquito repellent spray comprises flose caryophylli, artemisia argyi, eupatorium fortunei, agastache rugosus, fennel,herba menthae, borneol, radix angelicae, asarum and round cardamon seed. The artemisia argyi can achieve the effect of repelling mosquitoes, and the eupatorium fortunei is used for treating itching caused by mosquito bites and has an inhibiting effect on corynebacterium diphtheriae, staphylococcus aureus, sarcina, proteusbacillus vulgaris, typhoid bacillus and the like; and the agastache rugosus has a sterilization effect, the fennel and asarum have an antibacterial effect, and good mosquito repelling and itching relieving effects are achieved.
Owner:WUHAN SUNHY BIOLOGICAL
Process of conjugation and novel synthetic oligosaccharide-protein conjugates obtained thereof
InactiveUS10105438B2High yieldHigh purityAntibacterial agentsBacterial antigen ingredientsThio-Tetanus toxoids
The present invention relates to an improved process of conjugation to obtain synthetic oligosaccharide-protein (OS-PR) conjugates. The process of synthetic OS-PR conjugation is a rapid process providing oligosaccharide-protein conjugates which are highly immunogenic and elicit specific and homogenous immune responses. The synthetic oligosaccharide comprising of four to eight repeating units of respective monomers and at least one in-built terminal amino linker, said synthetic polysaccharide mimics natural polysaccharide obtained from gram negative bacteria such as Neisseria meningitidis serogroups A, C, Y, W, X and Haemophilus influenzae and carrier protein is obtained from gram positive bacteria such as Clostridium tetani (tetanus toxoid) or Corynebacterium diphtheriae (CRM197) or their recombinant versions. The conjugation chemistry of the said oligosaccharide-protein conjugate of the present invention is thio-ether linkage. The present invention takes complete process time in the range of 14-22 hours. The said oligosaccharide-protein conjugates are useful in production of monovalent vaccine or multivalent combination vaccines and as diagnostic tool.
Owner:MSD WELLCOME TRUST HILLEMAN LAB PVT LTD
A kind of preparation method of diphtheria vaccine
ActiveCN104027797BHigh purityImprove controllabilityAntibacterial agentsBacterial antigen ingredientsFiltrationUltrafiltration
Owner:SHANDONG YIDU BIOTECH
Preparation method of adsorbed diphtheria, tetanus and acellular pertussis and hemophilus influenza type B tetravalent combined vaccine
InactiveCN107970442AAvoid the phenomenon of decreased immune responseImprove reliabilityAntibacterial agentsBacterial antigen ingredientsTetanusAdjuvant
The invention discloses a preparation method of an adsorbed diphtheria, tetanus and acellular pertussis and hemophilus influenza type B tetravalent combined vaccine. The preparation method comprises the steps of S1, establishment of strain libraries, including establishment of a pertussis strain library, establishment of a corynebacterium diphtheriae strain library, establishment of a tetanus bacillus strain library and establishment of a hemophilus influenza type B strain library; S2, preparation of a pertussis stock solution, including ammonium sulfate salting-out, density gradient centrifugation and glutaraldehyde detoxification; S3, preparation of diphtheria toxins; S4, preparation of tetanus toxins; S5, preparation of hemophilus influenza type B toxins; and S6, preparation of the tetravalent combined vaccine. The pertussis stock solution, the diphtheria toxins, the tetanus toxins and the hemophilus influenza type B toxins are mixed to prepare the tetravalent combined vaccine whichcan effectively prevent and treat pertussis, diphtheria, tetanus and influenza type B; and oil-in-water emulsion MF59 and PLG particles are adopted instead of an aluminum hydroxide adjuvant, so thatthe phenomenon of immune reaction reduction of PRP polysaccharides of DTaP-Hib can be effectively avoided, and the reliability and safety of the DTaP-Hib tetravalent combined vaccine can be improved.
Owner:CHENGDU KANGHUA BIOLOGICAL PROD
Cool moistening type herbal tea and preparation method thereof
InactiveCN102972584ASweating and antipyretic effect hasImprove cycle performanceTea substituesLicorice rootsBlood vessel
The invention relates to a cool moistening type herbal tea and a preparation method thereof. The cool moistening type herbal tea comprises the following raw materials, by weight, 10-60 parts of Chinese mesona herb, 10-40 parts of chrysanthemum, 0-5 parts of honeysuckle, 0-5 parts of mulberry leaf, 10 parts of japanese pogodatree flower, 2 parts of lotus leaf, 10 parts of dandelion, 4 parts of licorice root, and 10 parts of cape jasmine. The cool moistening type herbal tea has the following beneficial effects that: with the raw materials, a heat clearing detoxification effect is provided, wherein the honeysuckle and the like provide the heat clearing detoxification effect; a diaphoresis fever relieving effect is provided, wherein the effect is achieved by regulating temperature center; a body surface blood circulation enhancement effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs can provide effects of peripheral vessel expanding, body surface blood circulation enhancement and sweat gland secretion promoting so as to increase heat dissipating during aversion to cold; an antibacterial and antivirus effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs provide inhibition or killing effects for a lot of bacteria, viruses and other pathogenic microorganisms; the dandelion provides effects of wind-evil dispelling, fever relieving, dieresis and swelling subsiding; and the chrysanthemum provides inhibition effects for a lot of gram-positive bacteria, gram-negative bacteria and corynebacterium diphtheriae.
Owner:陈楚忠
Traditional Chinese medicinal spray for sterilization and disinfection in hospitals
The invention relates to a traditional Chinese medicinal spray for sterilization and disinfection in hospitals. The traditional Chinese medicinal spray consists of the following traditional Chinese medicinal raw materials by weight: 5-15g of fructus chebulae, 10-25g of radix tinosporae, 10-20g of tamarix chinensis, 5-15g of piper cubeba, 5-10g of hplef negundo chstetree leaves, 10-15g of scabrous mosla herb, 3-8g of zebrina pendula and 3-10g of leaves of Chinese loropetalum. The traditional Chinese medicinal spray disclosed by the invention is prepared from pure traditional Chinese medicines, and can be used for effectively killing staphylococcus aureus, escherichia coli, pneumococcus, streptococcus, pseudomonas aeruginosa, corynebacterium diphtheriae, staphylococcus albus and bacillus influenzae; the traditional Chinese medicinal spray is free from irritation as well as toxic and side effects, and can be widely applied to sterilization and disinfection in hospitals.
Owner:李怀生
Pill containing anise oil and cinnamon oil
InactiveCN105232629AEasy to makeEasy to useAntibacterial agentsDigestive systemStaphylococcus cohniiMotility
The invention discloses a pill containing anise oil and cinnamon oil. The pill comprises the following active pharmaceutical ingredients in parts by weight: 7-10 parts of anise oil and 3-5 parts of cinnamon oil. The pill has relatively strong inhibiting effects for staphylococcus aureus, pneumococcus, corynebacterium diphtheriae, bacillus subtilis, vibrio cholerae, typhoid bacillus, salmonella paratyphi, shigella dysenteriae, escherichia coli and common pathogenic bacteria, and is suitable for treatment for common diseases including influenza, upper respiratory infection, diarrhea, dysentery and the like. The pill further can promote gastrointestinal motility and relieve abdominal pain; the pill has the effect of raising leukocyte and boosting immunity, and is easy to prepare, and convenient to use.
Owner:莫兆钦
Cool moistening type herbal tea and preparation method thereof
InactiveCN102972582ASweating and antipyretic effect hasImprove cycle performanceTea substituesLicorice rootsRaw material
The invention relates to a cool moistening type herbal tea and a preparation method thereof. The cool moistening type herbal tea comprises the following raw materials, by weight, 10-60 parts of Chinese mesona herb, 10-40 parts of chrysanthemum, 0-5 parts of honeysuckle, 0-5 parts of mulberry leaf, 10 parts of japanese pogodatree flower, 2 parts of lotus leaf, 10 parts of dandelion, 4 parts of licorice root, and 10 parts of weeping forsythia fruit. The cool moistening type herbal tea has the following beneficial effects that: with the raw materials, a heat clearing detoxification effect is provided, wherein the honeysuckle and the like provide the heat clearing detoxification effect; a diaphoresis fever relieving effect is provided, wherein the effect is achieved by regulating temperature center; a body surface blood circulation enhancement effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs can provide effects of peripheral vessel expanding, body surface blood circulation enhancement and sweat gland secretion promoting so as to increase heat dissipating during aversion to cold; an antibacterial and antivirus effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs provide inhibition or killing effects for a lot of bacteria, viruses and other pathogenic microorganisms; the dandelion provides effects of wind-evil dispelling, fever relieving, dieresis and swelling subsiding; and the chrysanthemum provides inhibition effects for a lot of gram-positive bacteria, gram-negative bacteria and corynebacterium diphtheriae.
Owner:陈楚忠
Cool moistening type herbal tea and preparation method thereof
InactiveCN102972581ASweating and antipyretic effect hasImprove cycle performanceTea substituesLicorice rootsSweat gland
The invention relates to a cool moistening type herbal tea and a preparation method thereof. The cool moistening type herbal tea comprises the following raw materials, by weight, 10-60 parts of Chinese mesona herb, 10-40 parts of chrysanthemum, 0-5 parts of honeysuckle, 0-5 parts of mulberry leaf, 10 parts of japanese pogodatree flower, 2 parts of lotus leaf, 10 parts of dandelion, 4 parts of licorice root, and 10 parts of Chinese wolfberry root bark. The cool moistening type herbal tea has the following beneficial effects that: with the raw materials, a heat clearing detoxification effect is provided, wherein the honeysuckle and the like provide the heat clearing detoxification effect; a diaphoresis fever relieving effect is provided, wherein the effect is achieved by regulating temperature center; a body surface blood circulation enhancement effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs can provide effects of peripheral vessel expanding, body surface blood circulation enhancement and sweat gland secretion promoting so as to increase heat dissipating during aversion to cold; an antibacterial and antivirus effect is provided, wherein chrysanthemum and other exterior syndrome relieving drugs provide inhibition or killing effects for a lot of bacteria, viruses and other pathogenic microorganisms; the dandelion provides effects of wind-evil dispelling, fever relieving, dieresis and swelling subsiding; and the chrysanthemum provides inhibition effects for a lot of gram-positive bacteria, gram-negative bacteria and corynebacterium diphtheriae.
Owner:陈楚忠
Cryo-protective agents for microorganisms
InactiveUS20070280967A1Increase temperatureBacterial antigen ingredientsBacteriaMonosodium glutamateMicroorganism
A lyophilization medium fora microorganism is provided wherein the medium is substantiality free of animal-derived products and comprises yeast extract and monosodium glutamate. The lyophilisation medium can be used for cryoprotection of strains of bacteria such as Corynebacterium diphtheriae. Method for preparing a freeze-dried culture of a microorganism using the lyophilization medium, and lyophiles of microorganisms are also provided.
Owner:LEE TIM
Bioconjugate vaccines' synthesis in prokaryotic cell lysates
Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins, which may be utilized in vaccines, including anti- bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. Suitable carriers may include but are not limited to Haemophilus influenzae protein D (PD), Neisseria meningitidis porin protein (PorA), Corynebacterium diphtheriae toxin (CRM 197), Clostridium tetani toxin (TT), and Escherichia coli maltose binding protein, and variants thereof.
Owner:NORTHWEST UNIV +1
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com