The present invention relates to immunogenic compositions comprising a conjugate of a saccharide from
Streptococcus pneumoniae
serotype 8 and a
carrier protein, and a mixture consisting of capsular polysaccharides from
Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRM197
carrier protein, or a mixture consisting of capsular polysaccharides from
Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a
carrier protein, wherein the capsular polysaccharides from
Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to
protein D, the capsular
polysaccharide from
Streptococcus pneumoniae serotype 18C is conjugated to
tetanus toxoid and the capsular
polysaccharide from
Streptococcus pneumoniae serotype 19F is conjugated to
diphtheria toxoid. Said compositions are useful for the prevention and / or treatment of diseases caused by Streptococcus pneumoniae.