Group-A and group-C meningococcus polysaccharide-adsorption diphtheria tetanus combined vaccine and production process thereof

Abstract

The invention provides a group-A and group-C meningococcus polysaccharide-adsorption diphtheria tetanus combined vaccine and a production process thereof. The combined vaccine contains an adsorption diphtheria tetanus vaccine and a group-A and group-C meningococcus polysaccharide vaccine which are respectively contained in two reagent bottles, wherein the content of diphtheria toxoid in each 1ml of the adsorption diphtheria tetanus vaccine is below 20Lf, the content of tetanus toxoid is below 3Lf, the content of aluminum hydroxide is below 3mg, and the content of sodium chloride is 7.5mg-9mg;and each human dose, namely 0.5ml of the group-A and group-C meningococcus polysaccharide vaccine contains 50 micrograms of group-A meningococcus polysaccharide, 50 micrograms of group-C meningococcuspolysaccharide vaccine and 8mg of lactose. The combined process is mainly used for preventing multiple high-incidence diseases of children of 5 and 6 years old through one injection. The invention further provides the production process of the group-A and group-C meningococcus polysaccharide-adsorption diphtheria tetanus combined vaccine.

Description

technical field [0001] The invention belongs to the technical field of vaccine production, and in particular relates to a group A group C meningococcal polysaccharide-adsorbed diphtheria-tetanus combined vaccine and a production process. Background technique [0002] Meningococcal meningitis is an acute respiratory infectious disease caused by Neisseria meningitides (Nm). The incidence of meningococcal disease is very high, and there have been several periodic pandemics, which have claimed the lives of tens of thousands of people and caused huge losses. In recent years, epidemic meningitis has repeatedly caused outbreaks and epidemics among primary and middle school students in my country. It has brought a huge threat to the health of the majority of primary and middle school students. [0003] Diphtheria (diphtheria) is an acute respiratory infectious disease caused by diphtheria bacillus, characterized by fever, shortness of breath, hoarseness, barking cough, white pseudome...

AI Technical Summary

Problems solved by technology

[0005] In recent decades, according to the immunization plan, the country has injected meningitis vaccine, diphtheria and tetanus vaccines to children free of charge. However, these vaccines have a single effect. The role of diphtheria and tetanus, and children aged 5-6 are the high-incidence group of these four epidemics, and they need to strengthen immune protection. Group A and group C meningococcal polysaccharide-adsorbed diphtheria-tetanus combined vaccine only needs one injection for the above situations , can prevent 4 kinds of epidemic diseases for children aged 5-6 at the same time

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